CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciencias Biologicas from Universidade Federal do Rio de Janeiro (1997), master's at Byophysics from Universidade Federal do Rio de Janeiro (1999) and doctorate at Microbiology from Universidade de São Paulo (2003). Has experience in Microbiology, focusing on Microbiology, acting on the following subjects: reparo de dna, genoma, peroxido de hidrogenio, cana-de-açúcar and transferência horizontal. (Source: Lattes Curriculum)
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In this request, we aim to replace equipment in the DNA sequencing and mass spectrometry facilities at CEFAP-USP. We are requesting the NextSeq2000 large-scale sequencer, which will replace the current NextSeq500 equipment at CEFAP through a trade-in process. Additionally, we are also requesting two chromatography systems, Vanquish Neo and Vanquish Flex, for use in conjunction with the ma…
The world population is getting older and older. Unfortunately, this increased life expectancy is generally associated by so-called age-related vascular diseases, such as dementia, heart infarct, and stroke, which profoundly compromise the quality of life of the elderly. Age-related disorders are generally viewed as necessary evil. Our project challenges this dogma, as we propose that the…
Proteus mirabilis is a bacterial pathogen primarily involved in urinary tract infections. This bacterial species often carries integrative conjugative elements (ICEs) from the SXT/R391 family. These are responsible for the spread of antimicrobial resistance genes. These elements are large and carry, in addition to resistance genes and those responsible for their excision and conjugation, …
The SOS response is a cellular mechanism of protection against genotoxic stress. In addition to regulating the expression of DNA repair genes, this cellular response also induces mutagenesis, because of the regulation of error prone DNA polymerases. Several classes of antimicrobials are inducers of the SOS response, and therefore can accelerate the emergence of mutants in bacterial popula…
Antibiotic resistance in bacteria is one of the greatest threats to global public health, and the spread of resistance genes, such as those encoding ¿-lactamases, has complicated the treatment of severe infections. Among these enzymes, CMY-2, an AmpC-type ¿-lactamase present in plasmids, has stood out for conferring resistance to broad-spectrum cephalosporins and other ¿-lactams. Recently…
Pseudomonas aeruginosa is a pathogenic bacterium considered a critical priority by the WHO for research and development of new antibiotics. Previous studies identified the FAN1 protein in this important microorganism, a homologue of the human DNA repair enzyme, and characterized its in vitro activity in the repair of interstrand crosslink lesions, however, the in vivo importance and other…
Both ppGpp signaling and the SOS response, induced by DNA damage, are universal in bacteria and central to survival in the environment, pathogenesis and antimicrobial resistance. The project aims to use bacterial genetics, molecular biology and biochemistry techniques to understand the interaction between these two responses in the opportunistic pathogen Pseudomonas aeruginosa and the mod…
The association of Mobile Genetic Elements (MGEs) with the increase in the number of multidrug-resistant bacteria has become increasingly evident, however the biology of the relationship of these elements with their hosts is a complex aspect. Integrative and Conjugative Elements (ICEs) of the SXT/R391 family are MGEs that integrate into the chromosome and disseminate resistance genes main…
Chromosomal insertion mechanisms are effective for genetic engineering and ideal for DNA integration in situations where plasmid selection is not feasible, such as in vaccine strains or for environmental release. The creation of new mechanisms for gene insertion into the chromosome is important to expand the range of gene expression systems, reach new bacterial species, and also to use di…
Genetic sequencing of Caulobacter crescentus allowed the identification of open reading frames (ORFs) and genes in its genome. Some of these genes are conserved, making it possible to predict their function. On the other hand, others have not yet been adequately characterized, including the operon formed by the genes CCNA_02417 and CCNA_02418, which encodes DNA repair proteins that, toget…
(Only some records are available in English at this moment)
Pseudomonas aeruginosa, a gram-negative bacterium, exhibits remarkable adaptabilityto diverse environments due to its diversity of metabolic pathways and regulatorygenes. As a significant opportunistic pathogen, it poses a considerable threat to humanhealth, particularly among immunocompromised individuals. Common infectionscaused by P. aeruginosa include respiratory tract infections, uri…
Pseudomonas aeruginosa is an important human opportunistic pathogen, responsible for the high mortality rates in patients with cystic fibrosis. This bacterium has great ability to adapt to adverse situations, which facilitates the establishment and persistence of infection. The inappropriate antibiotic therapy and contact with sub-inhibitory concentrations may cause the bacteria to respon…
| 2 / 2 | Ongoing grants |
| 4 / 2 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 19 / 16 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 31 / 26 | All research grants and scholarships |
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