CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Professor Emer Suavinho Ferro is a faculty member at ICB-USP, where he coordinates the Laboratory of Intracellular Peptides Pharmacology. His research focuses on peptides generated by intracellular proteolysis, whose functions have therapeutic potential. The group has identified bioactive peptides with effects on neuroprotection, energy metabolism, and modulation of the endocannabinoid system; examples such as hemopressin, NFKF, Pep5, Ric4, and Pep19 are documented in the scientific literature. Pep19 (DIIADDEPLT) is the first intracellular peptide with an approved therapeutic application for human and animal use, acting orally as a peripheral inverse agonist of the CB1 receptor. Several claims related to the therapeutic effects of Pep19 have already been approved by the FDA, supporting its safety and efficacy. (Source: Lattes Curriculum)
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Oligopeptidases were first described as kininases from rabbit brain in the early 70's by Prof. Antonio C. M. Camargo at USP Ribeirão Preto Medical School. Studies from our research group suggested that more than 90% of thimet oligopeptidase (EC3.4.24.15; EP24.15) and neurolysin (EC3.4.24.16; Nln) are concentrated inside the cells; these data suggested some doubts about the major function …
Endo-oligopeptidases is a denomination coined by Camargo and cols. (OLIVEIRA, et al., 1976) to describe the substrate specificity of two enzymes named endo-oligopeptidases A and B, which only cleaves short peptides (from 5-17 amino acids). At this time we intend to keep on investigating the cell biology and function of endo-oligopeptidases EP24.15 (EC 3.4.24.15) and EP24.16 (EC 3.4.24.16)…
(Only some records are available in English at this moment)
Obesity represents a major public health problem given its high prevalence and increased risk for the development of other diseases such as Heart Disease, Diabetes Mellitus, and various Cancers. The steady increase in the overweight and obese population creates opportunities for therapeutic innovation with the aim of improving their quality of life. In the present project, C57BL6 knockout…
Intracellular peptides are peptides that escape cytosolic proteolytic degradation, are not part of autoimmune recognition, and accumulate inside the cells. The majority of intracellular peptides has unknown functions. Recently, our group observed the presence of intracellular peptides on the structure of protein complexes available on Protein Data Bank (PDB). From 627 identified human pep…
(Only some records are available in English at this moment)
Perfluorinated chemicals (PFCs) are environmental hazards that can accumulate in the environment and in the body after ingestion. Humans are exposed to PFCs through dust, through food and not least through drinking water. Based on several lines of ongoing studies, we particularly examine the possibility that activation of brown adipose tissue (BAT) may be an unexpected outcome of exposure…
| 13 / 6 | Completed research grants |
| 34 / 12 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 49 / 19 | All research grants and scholarships |
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