CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Alemanha
He obtained a Bachelor degree in Biology from the Bielefeld University, Germany (1996) and a Master degree in Biology from the Bielefeld University (1999). He performed doctoral studies (PhD) in Biology/Biochemistry at the Bernhard Nocht Institute for Tropical Medicine (2002) and was Wellcome International Postdoctoral Fellow at the Wellcome Trust Biocentre, University of Dundee, UK (2002-2004) as well as Principal Investigator at the Bernhard Nocht Institute for Tropical Medicine (2004-2010). He did Habilitation and Venia-legendi in Zoology at the University of Hamburg, Germany (2007) which was also accredited as Livre-docência from the University of São Paulo (2013). He was "Jovem Pesquisador em Centros Emergentes" at the Institute of Biomedical Sciences, University of São Paulo (ICB-USP), Vice-President (in exercise) for International Affairs, ICB-USP (2014-2017 (-2019)) and Head (2018-2022) and Vice-Head (2022-2024) of the Department of Parasitology, ICB-USP (2018-2022). Currently, he is Full-Professor for Molecular Parasitology at ICB-USP, Coordenator of the Master (MSc) double degree programme between ICB- and IB-USP and University of Münster (WWU), Germany and the PhD double degree propramme between ICB-USP and University of Groningen (RUG), Netherlands, Founder of the "BSL3 Cell Culture Facility for Vector and Animal Research". He has experience in molecular parasitology, biochemistry and cell biology and is working on the vitamin B1 and B6 metabolism in Plasmodium falciparum and Staphylococcus aureus MRSA. Furthermore, he is also performing drug discovery against viral diseases such as SARS-CoV-2. (Source: Lattes Curriculum)
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Infectious diseases are a significant burden on public health and economic stability of societiesall over the world. The threat posed by infectious diseases is further deepened by the continuedemergence of new, unrecognized, and old, re-emerging infectious diseases. This becameeven more prominent by the continuously increasing air traffic and the resulting possible globaldissemination of …
In terms of the proposed collaborative research and educational activities the applicants plan to initiate a long term collaboration, particular involving young scientists and PhD students, in distinct research topics covering drug discovery, drug design and drug delivery. The complementary expertise of the applicants and Institutions involved will be first focused and merged to identif…
Infections with methicillin resistant Staphylococcus aureus (MRSA) are a global problem. Besides hospital acquired MRSA, also community associated MRSA strains have emerged that cause skin and soft tissue infections but also life threatening endocarditis and pneumonia. The increasing appearance of multidrug resistants trains urgently requires novel therapeutic approaches in order to keep …
Infectious diseases are a threat to mankind and currently the causative pathogens are spreading geographically due to globalization and developing drug resistance. Current resistance to chemotherapeutics is occurring to almost all pathogens and therefore new drug targets and/or novel modi of drug target efficacy is urgently needed. In this grant application the focus will be drawn on suic…
(Only some records are available in English at this moment)
Genome integrity is continuously challenged by DNA lesions in all organisms. Thus, a functional DNA repair mechanism is essential for cell viability. DNA repair processes include the nucleotide exchange repair (NER), base exchange repair (BER), mismatch repair (MMR), single-strand annealing (SSA), homologous recombination (HR) and non-homologous end-joining (NHEJ). The heterodimeric endon…
The vector mosquito populations from different locations in Brazil may present differences in susceptibility to arboviruses. This variation in infection capacity may be related to several factors, such as genomic diversity of the pathogen and/or host, and environmental conditions of the habitat where the vector is inserted. Therefore, this project aims to evaluate the infection profile of…
(Only some records are available in English at this moment)
Malaria still represents a significant public health problem worldwide, yet it affects disproportionally people leaving in impoverished and developing countries, killing more than half a million individuals year-round. So far, we are unlikely to meet the ambitious goal of significantly reducing malaria incidence and mortality by 90% until 2030, mostly due to vector-parasite adaptation, de…
The aim of this research project is to evaluate the effect of molecules selected by rational drug design to interfere with SARS-CoV-2 virion production in vitro by targeting the E protein of the virus.The capacity of CoV E protein to form homo-oligomers targeted to the Golgi membrane has been widely described. Recently, this structure forming an ion channel has been attributed to neutrali…
Malaria is a potentially fatal disease caused by protozoa of the genus Plasmodium and mainly by the species falciparum and vivax which is transmitted to humans by the vector Anopheles through the bites of infected female mosquitoes. However, malaria can be prevented and treated. According to the World Health Organization (WHO) in 2018, almost half of the world population was susceptible t…
(Only some records are available in English at this moment)
P. vivax is the primary cause of malaria outside Africa and an important, but often neglected, source of morbidity and mortality in endemic areas where the burden of P. falciparum malaria has been controlled. Public health strategies implemented to eliminate malaria in these areas affect both parasites unevenly due to specific biological differences between species. P. vivax has the impor…
This research project aims to assess the impact of molecules identified through rational drug design that can disturb the assembly of SARS-CoV-2 virions in vitro by targeting the E protein of the virus. In this context the main goals of the proposed research project are to gain detailed structural insights into the pentameric structure of the E protein, its subcellular localization, and i…
Reversible post-translational modification of proteins by ubiquitin (Ub) and ubiquitin-like modifiers (Ubls) serves an essential regulatory mechanism for fundamental cellular processes such as cell cycle progression, DNA damage repair, nucleocytoplasmic transport, transcription, and chromatin remodelling. Protein modification by small ubiquitin-like modifiers (SUMOs) is mediated by the co…
Nuclear receptors (NRs) are fundamental regulators of several biological processes in which they are controlling the transcription of target genes in eukaryotic cells that are modulated in a ligand-dependent manner. Most ligands bind to a pocket in the interior of the ligand-binding domain. However, there is experimental evidence of the existence of alternative ligand-binding sites on the…
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