Iolanda Midea Cuccovia

• Abstract

  Using micelles and vesicles as models we will focus questions representing new frontiers in the study of interfacial properties using methods we have used for decades and deploying new techniques in collaboration with researchers from Brazil and abroad. Can we design (synthesize) self-aggregating surfactants that form vesicles capable of catalyzing and self-replicate? What is the role of…

  Multi-User Equipment, previously approved in grant 2015/08166-5: stopped-flow, AP.EMU

• Abstract

  Using micelles and vesicles as models we will focus questions representing new frontiers in the study of interfacial properties using methods we have used for decades and deploying new techniques in collaboration with researchers from Brazil and abroad. Can we design (synthesize) self-aggregating surfactants that form vesicles capable of catalyzing and self-replicate? What is the role of…

  Interfacial chemistry: drugs, peptides and ezymes interactions with membrane models, AP.TEM

• Abstract

  Fundamental and applied research in bio-mimetic systems, using micelles and vesicles as models, is the focus of our line. We study structure of aggregates, catalytic properties of micelles and vesicles, mechanism of chemical reactions and protein/membrane interaction. Of these contributions, we should highlight (Magazine, year, quotation): vesicles prepared with phosphate diester (BBRC, 1…

  Chemical and biological reactivity in interfaces, AP.TEM

(Only some records are available in English at this moment)

• Abstract

  Cell Penetrating Peptides (CPP) invade eukaryotic cells without damaging the plasma membrane. TAT, a widely used CPP, is an intracellular carrier of drugs, proteins and DNA. The CPP penetration mechanism into cells, despite their increasing use, is controversial. Experimental and theoretical findings diverge; a group of authors propose that penetration depends on classic mechanisms such a…

  How do cell penetrating peptides enter cells?, BP.DD

• Abstract

  Peptide interaction Antimicrobial Agents and Membrane Model. Antimicrobial peptides are molecules that act on membranes causing disturbances that can lead to transient formation of pores or the removal of a portion of the lipid bilayer via a detergent-like action. These molecules may have different structures, many of which have predominantly helical secondary structures. These peptides a…

  Interfacial chemistry: drugs, peptides and ezymes interactions with membrane models, BP.PD

• Abstract

  Cationic membrane-active peptides (CMAP) are protagonists in many processes involving lipid membranes such as pore formation, vesicle fusion and rupture. Two CMAP groups stand out as potential novel drug or drug carrier candidates. Antimicrobial peptides (AMP), are a promising class of antibacterial agents and cell-penetrating peptides (CPP), are already candidates for drug-delivery. Many…

  Coarse graining analysis of the interaction of antimicrobial and cell penetrating peptides with lipid vesicles, BE.EP.DD