CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Faculdade de Ciências Farmacêuticas da Usp from Universidade de São Paulo (1974), master's at Biochemistry from Universidade de São Paulo (1977) and doctorate at Biochemistry from Universidade de São Paulo (1980). Has experience in Byophysics, focusing on Molecular Biophysics, acting on the following subjects: micelas, vesiculas, micelles, vesicles and catalise. (Source: Lattes Curriculum)
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Using micelles and vesicles as models we will focus questions representing new frontiers in the study of interfacial properties using methods we have used for decades and deploying new techniques in collaboration with researchers from Brazil and abroad. Can we design (synthesize) self-aggregating surfactants that form vesicles capable of catalyzing and self-replicate? What is the role of…
Using micelles and vesicles as models we will focus questions representing new frontiers in the study of interfacial properties using methods we have used for decades and deploying new techniques in collaboration with researchers from Brazil and abroad. Can we design (synthesize) self-aggregating surfactants that form vesicles capable of catalyzing and self-replicate? What is the role of…
Fundamental and applied research in bio-mimetic systems, using micelles and vesicles as models, is the focus of our line. We study structure of aggregates, catalytic properties of micelles and vesicles, mechanism of chemical reactions and protein/membrane interaction. Of these contributions, we should highlight (Magazine, year, quotation): vesicles prepared with phosphate diester (BBRC, 1…
(Only some records are available in English at this moment)
Interfaces are common boundaries between two independent and adjacent systems that separate and communicate bodies, substances or phases. Most chemical reactions in biology occur at interfaces between, for example, proteins/solution or membranes/medium. The focus of our projects is the study of biologically relevant interfaces using appropriate models to understand distinct aspects of int…
Cell Penetrating Peptides (CPP) invade eukaryotic cells without damaging the plasma membrane. TAT, a widely used CPP, is an intracellular carrier of drugs, proteins and DNA. The CPP penetration mechanism into cells, despite their increasing use, is controversial. Experimental and theoretical findings diverge; a group of authors propose that penetration depends on classic mechanisms such a…
Peptide interaction Antimicrobial Agents and Membrane Model. Antimicrobial peptides are molecules that act on membranes causing disturbances that can lead to transient formation of pores or the removal of a portion of the lipid bilayer via a detergent-like action. These molecules may have different structures, many of which have predominantly helical secondary structures. These peptides a…
Cationic membrane-active peptides (CMAP) are protagonists in many processes involving lipid membranes such as pore formation, vesicle fusion and rupture. Two CMAP groups stand out as potential novel drug or drug carrier candidates. Antimicrobial peptides (AMP), are a promising class of antibacterial agents and cell-penetrating peptides (CPP), are already candidates for drug-delivery. Many…
| 5 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 7 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 14 / 8 | All research grants and scholarships |
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