Ricardo de Lima Zollner
CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas (FCM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Medicina FMRP from Universidade de São Paulo (1981), master's at Clinica Medica from Universidade de São Paulo (1987) and ph.d. at Clinica Médica from Universidade de São Paulo (1990). Has experience in Medicine, focusing on Allergology and Clinical Imunology, acting on the following subjects: alergia, nod mice, cytokines, auto imunidade and diabetes. (Source: Lattes Curriculum)
- Anti-diabetogenic, antioxidant / antiinflammatory / antiapoptotic effects of aqueous extract of Passiflora alata and components vitexin, Isoorientin, rutin and catechin, AP.R
Abstract
The search for new drugs from medicinal plants has motivated the research for alternative substances with potential anti-inflammatory that could aid in the treatment of inflammatory diseases, as in the case of type 1 diabetes. In the previous study, (International Immunopharmacology - title: Antioxidant and anti-diabetic potential of Passiflora alata Curtis aqueous leaves extract in typ...
- Identification and Characterization of compounds of the aqueous extract of Passiflora alata. Effect of treatment on diabetes expression and modulation of inflammation in pancreatic islets in the NOD mouse model of type 1 diabetes (non-obese diabetic), AP.R
Abstract
Our laboratory has been devoted to study substances that modulate inflammation in experimental type 1 diabetes. Among the projects undertaken highlight the study of diacerhein and gangliosides (drugs available for treatment of inflammation and neural regeneration) drugs with properties of modulation of islets inflammation decreasing the diabetes expression in NOD mice. So, we are curren...
- In vivo study of basal transcription factor GATA-3, histamine receptors 1 and 2, ige-dependant histamine-releasing factor mRNA expression changes in peripheral mononuclear blood cells during bee., AR.EXT
- Expression of dependent-cyclin kinase (Cdks 1, 2, 4 e 6) on pancreatic islets of NOD mouse (non-obese diabetic) treated with leaves aqueous extract of Passiflora alata, BP.MS
Abstract
The search for new drugs from medicinal plants has motivated the research for alternative substances with potential anti-inflammatory that could aid in the treatment of inflammatory diseases, as in the case of type 1 diabetes. As a tool to study these substances that modulate inflammation, is common to use animals with a susceptibility to develop diabetes, as NOD mice. The literature, n...
- Modulatory effects of gangliosides on pancreas B-cells regeneration factors in non-obese diabetic (NOD) mice, BP.MS
Abstract
NOD (non-obese diabetic) mice are a very useful and important tool for autoimmune type 1 diabetes (DM-1) studies. Until approximately 3-4 weeks of life, histological studies have shown a progressive migration of immune cells to the pancreas islets. These cells surround the islet (peri-insulitis) without significant b-cell destruction. In the subsequent weeks, the infiltrating immune cel...
| 8 / 3 | Completed research grants |
| 14 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 23 / 6 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 3 |
| Citations | 32 |
| Cit./Article | 10.7 |
| Data from Web of Science | |
COLOMEU, T. C.; FIGUEIREDO, D.; CAZARIN, C. B. B.; SCHUMACHER, N. S. G.; MAROSTICA, JR., M. R.; MELETTI, L. M. M.; ZOLLNER, R. L.. Antioxidant and anti-diabetic potential of Passiflora alata Curtis aqueous leaves extract in type 1 diabetes mellitus (NOD-mice). International Immunopharmacology, v. 18, n. 1, p. 106-115, JAN 2014. Web of Science Citations: 12. (11/06559-4)
FIGUEIREDO, D.; COLOMEU, TALITA CRISTINA; GONZALEZ SCHUMACHER, NAYARA SIMON; STIVANIN-SILVA, L. G.; BETIM CAZARIN, CINTHIA BAU; MOLINA MELETTI, LAURA MARIA; ROMANI FERNANDES, LUIS GUSTAVO; PRADO, MARCELO ALEXANDRE; ZOLLNER, R. L.. Aqueous leaf extract of Passiflora alata Curtis promotes antioxidant and anti-inflammatory effects and consequently preservation of NOD mice beta cells (non-obese diabetic). International Immunopharmacology, v. 35, p. 127-136, JUN 2016. Web of Science Citations: 5. (13/25256-8, 11/06559-4, 11/15763-4)
D. VENTURA-OLIVEIRA; C.A. VILELLA; M.E. ZANIN; G.M. CASTRO; D.C. MOREIRA FILHO; R.L. ZOLLNER. Kinetics of TNF-alpha and IFN-gamma mRNA expression in islets and spleen of NOD mice. Brazilian Journal of Medical and Biological Research, v. 35, n. 11, p. 1347-1355, Nov. 2002.
GONZALEZ SCHUMACHER, NAYARA SIMON; COLOMEU, TALITA CRISTINA; DE FIGUEIREDO, DANIELLA; CARVALHO, VIRGINIA DE CAMPOS; BETIM CAZARIN, CINTHIA BAU; PRADO, MARCELO ALEXANDRE; MOLINA MELETTI, LAURA MARIA; ZOLLNER, RICARDO DE LIMA. Identification and Antioxidant Activity of the Extracts of Eugenia uniflora Leaves. Characterization of the Anti-Inflammatory Properties of Aqueous Extract on Diabetes Expression in an Experimental Model of Spontaneous Type 1 Diabetes (NOD Mice). ANTIOXIDANTS, v. 4, n. 4, p. 662-680, DEC 2015. Web of Science Citations: 15. (11/06559-4)
(References retrieved automatically from State of São Paulo Research Institutions)
FIGUEIREDO, Daniella de. Expressão de quinases dependentes de ciclinas (Cdks 1, 2, 4 e 6) em ilhotas pancreáticas de camundongos NOD (non-obese diabetic) tratados com extrato aquoso das folhas de Passiflora alata. 2014. Dissertação (Mestrado) - Faculdade de Ciências Médicas. Universidade Estadual de Campinas (UNICAMP).
OLIVEIRA, Danielle Ventura de. Estudo temporal da expressão genica de Fas, Fas-ligante, Bcl-w e citocinas Th1 em ilhotas pancreaticas, sangue e baço de camundongo NOD (diabetico não obeso). 2002. Dissertação (Mestrado) - Faculdade de Ciências Médicas. Universidade Estadual de Campinas (UNICAMP).
TREVIZAN, Giovanna. Imunoterapia especifica : efeitos sobre expressão de receptores de histamina, fator de liberação de histamina, GATA-3 e cadeia y do receptor de alta afinidade de IgE em celulas linfomononucleares de pacientes alergicos ao veneno de Apis mellifera. 2010. Dissertação (Mestrado) - Faculdade de Ciências Médicas. Universidade Estadual de Campinas (UNICAMP).
SILVA, Luís Guilherme Stivanin. Modulação da expressão de fatores de regeneração/crescimento de ilhotas pancreáticas e tecido acinar pancreático em camundongos NOD (non-obese diabetic) tratados com gangliosídeos = : Modulation of regeneration/growth factors expression in pancreatic exocrine and endocrine tissue of NOD (non-obese diabetic) mice treated with gangliosides. 2012. Dissertação (Mestrado) - Faculdade de Ciências Médicas. Universidade Estadual de Campinas (UNICAMP).