Associate Professor at Nursing School at Campinas University in Fundamentals of Nursing. Graduated in Nursing in Faculty of Medical Sciences at UNICAMP in 1990. Master in Physiology and Biophysics at Biology Institut at Unicamp in 2002. PhD in Medical Pathophysiology at Faculty of Medical Sciences at UNICAMP in 2005. Post-Doctorate with FAPESP scholarship from 2006 to 2008. Works in the investigation of therapeutic targets and substances capable of controlling the process of wound healing and obesity. PQ2 Productivity Grant (CNPq) (Source: Lattes Curriculum)
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In the past few decades, the study of Brown Adipose Tissue (BAT) thermogenesis in adult human brought new insights to the problem of obesity. The presence of this tissue in newborn was already known and its importance to maintain body temperature and survival are undeniable. A recent study from our group demonstrated that mice lacking IL10, an antiinflammatory cytokine, are incapable to r…
A high fat diet (HFD) leads to development of resistance to leptin and insulin because of the installation of an inflammatory process in the hypothalamus, a key phenomenon link the development of obesity. Furthermore, a HFD leads to an apoptotic signaling pathways that culminate in death of hypothalamic neurons, especially those responsible for the anorexigenic stimulus. As a result, hypo…
Obesity and diabetes are among the most prevalent diseases in the world. The mechanisms responsible for the frequent clinical association between these two conditions are not completely known. According to animal models studies, leptin and insulin resistance in hypothalamic areas causes an imbalance in energy homeostasis favoring the gradual weight gain. Hypertrophied adipose tissue macro…
Obesity is a chronic, progressive disease and an important risk factor for the development of type 2 diabetes mellitus. Diabetes affects more than 422 million people worldwide and with the aging of the population, the prevalence has increased dramatically. Studies of genes that contribute to the development of these diseases make it clear how complex the pathophysiology of chronic and mul…
In the past few decades, the study of Brown Adipose Tissue (BAT) thermogenesis in adult human brought new insights to the problem of obesity. The presence of this tissue in newborn was already known and its importance to maintain body temperature and survival are undeniable. A recent study from our group demonstrated that mice lacking IL10, an anti-inflammatory cytokine, are incapable to…
The high prevalence of skin diseases, increasing obesity, diabetes, and aging are factors associated with chronic wounds, skin cancer, and psoriasis. The treatment of these skin diseases is challenging because of worse quality of life and functional capacity in addition to high health costs. Glutamic acid, an excitatory neurotransmitter of the central nervous system plays important roles …
Diabetes is a serious chronic disease that is associated with increased morbidity and premature mortality. Its prevalence has been increasing exponentially in recent decades, becoming a public health problem in many countries. The global diabetes epidemic is driven by increasing in the obesity. Excess body fat increases the risk of insulin resistance and glucose intolerance, and contribut…
The high fat diet leads to the development of resistance to leptin and insulin due the installation of an inflammatory process in the hypothalamus, placing this phenomenon with the key in development of obesity. Furthermore, the high fat diet leads to activation of apoptotic signaling pathways that culminate in death of hypothalamic neurons, especially those responsible for the anorexigen…
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Emerging data demonstrate that microglial inflammatory signaling plays a pivotal role in the development of obesity induced-hypothalamic inflammation. In the early stages of hypothalamic inflammation, cells from microglia recognize the excess of saturated fatty acids (SFAs) from the diet and activate an important inflammatory response. Due to fenestrated nature of the blood-brain barrier …
| 1 / 1 | Ongoing research grants |
| 3 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 6 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 13 / 10 | All research grants and scholarships |
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CV Lattes
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