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Evaluation of interleukin-10 modulation in brown adipose tissue Termogenesis in newborn: therapeutic strategies

Grant number: 19/05210-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2019
Effective date (End): August 31, 2021
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Eliana Pereira de Araujo
Grantee:Bruna Bombassaro
Home Institution: Faculdade de Enfermagem. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID

Abstract

In the past few decades, the study of Brown Adipose Tissue (BAT) thermogenesis in adult human brought new insights to the problem of obesity. The presence of this tissue in newborn was already known and its importance to maintain body temperature and survival are undeniable. A recent study from our group demonstrated that mice lacking IL10, an anti-inflammatory cytokine, are incapable to respond to cold due to mitochondrial defects on BAT. Humans that have deficiency in IL10 also exhibit similar mitochondrial problems. In this context, SIDS (Sudden Infant Death Syndrome) is an important cause of death in newborns during the first year of life and can be defined as death with not known cause even after thorough investigation. Despite the efforts to unravel its cause, the mechanisms leading to SIDS remain unclear. A study published recently described immunological polymorphisms in SIDS cases and found strong association between IL10 gene variations and the disease. To address this issue, our aim is to evaluate the importance of IL10 in body temperature regulation both in human newborns and mouse model. Besides that, explore therapeutic strategies to increase BAT function to overlap IL10 absence, perhaps through CD1, an immune molecule recently described as a BAT activator and immunological regulator in the central nervous system.