CV Lattes
ResearcherID
ORCID
Google Scholar Citations
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor - Institute of Biomedical Sciences and School of Medicine at University of Sao Paulo, Brazil. Visiting Professor - Stanford University School of Medicine CA-USA. Founder and director - SPARK-Brasil. Research interest - cell metabolism. Member - Brazilian Academy of Sciences, São Paulo Academy of Sciences and Global Young Academy. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Peripheral arterial disease (PAD) affects over 200 million people worldwide, causing significant disability and death. Typically, PAD is due to atherosclerosis, with obstruction of the iliac, femoral, and/or infrapopliteal arteries, and consequent reduction of blood supply to the lower extremities. Most of medical interventions of PAD stemmed from a vascular disease perspective. Although …
Mitochondria are organelles that continually undergo fission and fusion (mitochondrial dynamics). These opposing processes work together to maintain mitochondrial shape, size, number and function. Disruption of mitochondrial dynamics results in the accumulation of fragmented and dysfunctional mitochondria, contributing to the establishment and progression of several degenerative diseases.…
Mitochondria are organelles that continually undergo fusion and fission. These opposite processes work together to maintain the shape, size, number and function of mitochondria. Recently, our group demonstrated that reestablishing mitochondrial fusion-fission balance through exercise or drug therapy is sufficient to restore mitochondrial bioenergetics and improves the prognosis of heart f…
Mitochondria are key organelles involved in ATP production and regulation of several signaling cascades that ultimately affect cell death and survival. Mitochondrial dysfunction plays a critical role in the development and progression of cardiovascular diseases, such as myocardial infarction. Therefore, mitochondria have become an attractive therapeutic target for the treatment of cardiov…
4-hydroxy-2-nonenal (4-HNE) is a major by-product of lipid peroxidation, a process that is exacerbated under oxidative stress conditions. This aldehyde is highly reactive with proteins, lipids and DNA, causing target loss of function and degradation in most cases. For this reason, accumulation of 4-HNE has been correlated with the establishment and progression of many diseases, including …
(Only some records are available in English at this moment)
Amyotrophic Lateral Sclerosis (ALS) is a lethal neurodegenerative disease that affects 0.01% of the global population. The disease causes intrinsic changes that lead to the death of motor neurons and muscle atrophy, resulting in muscle weakness and paralysis in more advanced stages. Clinical data show that ~50% of patients with ALS present non-motor symptoms, raising the hypothesis that d…
It is currently known that the pathophysiology of amyotrophic lateral sclerosis (ALS) is associated with mitochondrial dysfunction, excessive lipid peroxidation and consequent accumulation of cytotoxic aldehydes. Among these aldehydes, acetaldehyde can be highlighted, an electrophilic aldehyde produced in the mitochondria capable of attacking nucleophilic amino acids and forming adducts w…
Amyotrophic lateral sclerosis (ALS) is a progressive and lethal neuromuscular degenerative disease that affects 0.01% (~10/100,000) of the population worldwide. Most ALS patients (familial or sporadic) display a progressive motor disorder after the disease onset; therefore, characterizing it as a degenerative syndrome triggered by a major disruption of the neuromuscular axis. However, ~50…
(Only some records are available in English at this moment)
Mitochondria are organelles that continually undergo fusion and fission. These opposing processes work together to maintain the shape, size, and number of mitochondria. Recently, our group demonstrated that reestablishing mitochondrial fusion-fission balance through physical exercise or pharmacological therapy is sufficient to recover mitochondrial bioenergetic metabolism and improve the …
Recently, knowledge about the pathophysiology of amyotrophic lateral sclerosis (ALS) has established that the formation and accumulation of aldehydes resulting from mitochondrial dysfunction and consequent excessive lipid peroxidation are extremely neurotoxic and are associated with the appearance of symptoms and progression of ALS in preclinical models. Among the various aldehydes, 4-hyd…
Mitochondria are organelles that continually undergo fission and fusion (mitochondrial dynamics). These opposing processes work together to maintain mitochondrial shape, size, number and function. Disruption of mitochondrial dynamics results in the accumulation of fragmented and dysfunctional mitochondria, contributing to the establishment and progression of several degenerative diseases.…
(Only some records are available in English at this moment)
Amyotrophic lateral sclerosis (ALS) is a terminal neurodegenerative disease characterized by skeletal muscle atrophy, paralysis, and death due to progressive loss of both upper and lower (cortical and spinal) motor neurons. A key pathological feature of both sporadic and familial ALS is the cytoplasmic mislocalization and aggregation of proteins such as SOD1 and TDP-43. Often underestimat…
Mitochondrial myopathy is a devastating disorder with no treatment available. The pathology of mitochondrial myopathy is characterized by an initial skeletal muscle degeneration due to mitochondrial dysfunction followed by a multi systemic effect such as lipolysis, gluconeogenesis, starvation-like response, among others, which contributes to disease progression and lethality. Targeting th…
Mitochondria are organelles that continually undergo fusion and fission. These opposite processes work together to maintain the shape, size, number and function of mitochondria. Mitochondrial fusion proteins (mitofusins 1 and 2) also play key role in the mitochondria-endo/sarcoplasmic reticulum (ER) communication; therefore, affecting critical intracellular processes such as phospholipids…
Impaired mitochondrial bioenergetics and defective endo/sarcoplasmic reticulum (ER) function have been individually reported in skeletal muscle under degenerative conditions in both humans and rodents. However, the dynamic interplay between these two key organelles under physiological conditions as well as its contribution to skeletal muscle degeneration remain elusive. Our preliminary fi…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 7 / 7 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 28 / 28 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 12 / 12 | Completed scholarships abroad |
| 55 / 55 | All research grants and scholarships |
| Associated processes | |