Associate Professor - Institute of Biomedical Sciences and School of Medicine at University of Sao Paulo, Brazil. Associate Professor - Stanford University School of Medicine CA-USA. Founder and director - SPARK-Brasil. Research interest - cell metabolism. Member - Brazilian Academy of Sciences, São Paulo Academy of Sciences and Global Young Academy. (Source: Lattes Curriculum)
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Mitochondria are organelles that continually undergo fusion and fission. These opposite processes work together to maintain the shape, size, number and function of mitochondria. Recently, our group demonstrated that reestablishing mitochondrial fusion-fission balance through exercise or drug therapy is sufficient to restore mitochondrial bioenergetics and improves the prognosis of heart f…
Mitochondria are key organelles involved in ATP production and regulation of several signaling cascades that ultimately affect cell death and survival. Mitochondrial dysfunction plays a critical role in the development and progression of cardiovascular diseases, such as myocardial infarction. Therefore, mitochondria have become an attractive therapeutic target for the treatment of cardiov…
4-hydroxy-2-nonenal (4-HNE) is a major by-product of lipid peroxidation, a process that is exacerbated under oxidative stress conditions. This aldehyde is highly reactive with proteins, lipids and DNA, causing target loss of function and degradation in most cases. For this reason, accumulation of 4-HNE has been correlated with the establishment and progression of many diseases, including …
Our current results demonstrate that intracellular protein quality control [machinery that detects, repairs and disposes cytotoxic proteins] is impaired during muscle dysfunction and wasting. We also show that pharmacological activation of β2-adrenoceptor induces an overall improvement of protein quality control-related mechanisms in skeletal muscle. Our next step is to establish a causal…
(Only some records are available in English at this moment)
Amyotrophic lateral sclerosis (ALS) is a progressive and lethal neuromuscular degenerative disease that affects 0.01% (~10/100,000) of the population worldwide. Most ALS patients (familial or sporadic) display a progressive motor disorder after the disease onset; therefore, characterizing it as a degenerative syndrome triggered by a major disruption of the neuromuscular axis. However, ~50…
Doxorubicin is a chemotherapeutic agent widely used in the treatment of carcinomas, sarcomas, and hematological tumors. However, 40% of treated display liver dysfunction, the main organ responsible for doxorubicin metabolism. The mechanisms involved in doxorubicin-induced hepatotoxicity are still unknown. It is known that doxorubicin accumulates in the liver in a dose-dependent manner, pr…
Heart failure (HF) is the leading cause of morbidity and mortality worldwide. Patients with HF are classified into two subgroups: HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). For decades, the majority all scientific attention was focused on the understanding of HFrEF due to of its practical diagnostic criteria and high prevalence of morbidity …
Mitochondria are organelles that continually undergo fusion and fission. These opposite processes work together to maintain the shape, size, number and function of mitochondria. Recently, our group demonstrated that reestablishing mitochondrial fusion-fission balance through exercise or drug therapy is sufficient to restore mitochondrial bioenergetics and improves the prognosis of heart f…
Heart failure is a degenerative syndrome that affects over 20 million people worldwide, being considered an important health public problem. Overall, 50% of heart failure patients die in the time-window of 5 years after diagnostics. Heart failure is classified into 2 classes: heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). H…
Aldehydes are highly reactive molecules in biological systems, where they bind to biomolecules such as DNA and proteins, resulting in functional jeopardy. Aldehydic attack may have an exogenous source, when directly absorbed from the environment, or be generated endogenously, after ethanol metabolism (generating acetaldehyde) or during mitochondrial lipid peroxidation (forming 4-hydroxyno…
(Only some records are available in English at this moment)
Impaired mitochondrial bioenergetics and defective endo/sarcoplasmic reticulum (ER) function have been individually reported in skeletal muscle under degenerative conditions in both humans and rodents. However, the dynamic interplay between these two key organelles under physiological conditions as well as its contribution to skeletal muscle degeneration remain elusive. Our preliminary fi…
Aldehydes are known as a class of highly reactive molecules and one of the most important drivers of redox damage in living cells. Aldehyde levels are mainly controlled by enzymes from Aldehyde Dehydrogenase superfamily (ALDH), of which ALDH2 is the most well characterized member. The main acetaldehyde metabolizing enzyme is mainly known by a mutation (E540K, named ALDH2*2) present in abo…
Geroscience has been successful in identifying evolutionarily conserved genes and molecular mechanisms capable of increasing longevity, mainly in the nematode Caenorhabditis elegans (C. elegans). However, it is still not clear whether this prolonged period of life is associated with improved healthspan (either relative or absolute). Healthspan is defined by the period of life in which an …
Doxorubicin is an anthracycline widely used to treat different types of cancer including leukemia, lymphomas and breast cancer. However, it has high risk of cardiotoxicity since it accumulates and negatively affects cardiac mitochondrial proteostasis and bioenergetics. Disruption of mitochondrial proteostasis triggers a conserved signaling pathway termed mitochondrial unfolded protein res…
The health benefits of exercise have long been recognized. The importance of autophagy for this process is now also well-established. New research suggests that significant benefits from exercise depend on selective degradation of defective mitochondria through mitophagy, but the mechanisms connecting these processes are unknown. This project aims to fill this critical gap in our knowledg…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 6 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 24 / 24 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 8 / 8 | Completed scholarships abroad |
| 44 / 44 | All research grants and scholarships |
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