CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
doctorate at Immunology from Universidade de São Paulo (1991). Has experience in Immunology, focusing on Celular Imunology, acting on the following subjects: citocinas, anticorpos ige, imunologia, alergia and resposta celular. (Source: Lattes Curriculum)
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Viral infection during pregnancy can pose risks such as vertical transmission and serious consequences for the fetus. Prenatal infection with arboviruses such as chikungunya (CHIKV) can have serious consequences with neurological damage to the fetus. Oropouche virus (OROV), an emerging arbovirus, causes oropouche fever and recent reports in 2024 have identified cases of fetal death and se…
Pregnancy is considered an active period of operative regulatory mechanisms for fetal development, but inflammatory disorders associated with viral infections may alter its outcome. This project addresses Human Immunodeficiency Virus (HIV) and Zika Virus (ZIKV) infection during pregnancy, both capable of congenital transmission with impact in the public health and do not yet have vaccine …
Adenosine triphosphate (ATP) is a predominantly intracellular molecule that can be released to the extracellular space during cellular activation, tissue stress or damage. Out of the cell, ATP can play a crucial role in immune responses and inflammation. Extracellular ATP can be rapidly converted to ADP, AMP and adenosine by ectonucleotidases, such as CD39 and CD73 that are present in the…
Vitamin A through its active metabolite retinoic acid is able to modulate the immune response and maintain mucosal homeostasis, especially in immunological sites such as the GutAssociated Lymphoid Tissue. The neonatal period is characterized by relative immunological immaturity and increased susceptibility to infections. In addition, the neonate is born with low concentrations of vitamin …
Zika Virus (ZKV) is an emergent flavivirus, transmitted by Aedes mosquitoes, causing a primary infection similar to dengue fever and showing remarkable teratogenic potential, particularly fetal microcephaly. Even though ZKV´s ability to infect different cell types, as epithelial cells, neuronal progenitors and cells from the maternal-fetal interface, indicates that this infection exhibits…
(Only some records are available in English at this moment)
Immune tolerance at the maternal-fetal interface is essential for fetal development and in controlling the response to infectious agents, such as Human Immunodeficiency Virus type 1 (HIV-1). Several mechanisms mediated by cells and/or factors act in gestational tolerance to control the generation of responses to alloantigens and also for immunity to infections that may occur at this stage…
The maternal-fetal interface is a site of ongoing immunoregulation, crucial for fetal development and protection against infections. Toll-like receptors (TLRs) play an essential role in the innate recognition of pathogens, including TLR10, which, although still poorly understood, is known to trigger both inflammatory and anti-inflammatory responses. Expressed in various cells, including t…
Herpes simplex virus (HSV), type 1 (HSV-1) and type 2 (HSV-2), co-evolved with humans and is present in high frequency in the general population, affecting approximately 190 million people worldwide. In general, with a mild or asymptomatic manifestation, it can cause serious neonatal infections, developing encephalitis and keratitis. Furthermore, neuroinflammation/immunosenescence with th…
(Only some records are available in English at this moment)
HIV infection during pregnancy can occur via intrauterine, intrapartum, and breastfeeding. To startthe antiretroviral therapy, occurred a significant reduction of viral vertical transmission. However, this increases the condition of exposed uninfected children. These children show immune dysfunctions especially in the first years of life. Considering the maternal-fetal imprint, epigenetic…
The new coronavirus-19 disease (COVID-19), caused by the infectious agent SARS-CoV-2 has become a worldwide public health problem. Data from several countries showed that the number of hospitalizations and deaths caused by the disease were higher in men than in women. This can, in part, be explained by sexual dimorphism, differences based on male and female gender that can influence the …
COVID-19, an infectious respiratory disease caused by SARS-CoV-2, has spread on an epidemic scale, infecting more than 62 million people worldwide to date. Virus infection can progress asymptomatically or generate more severe symptoms, influenced by the presence of comorbidities. Lymphopenia in patients affected with COVID-19 according to the severity of the symptom is recurrent, includin…
(Only some records are available in English at this moment)
Various factors play a fundamental role in maintaining immune system homeostasis between the mother and the newborn during infections, with it being essential to ensure that the intrauterine environment supports healthy fetal development. Among these factors, galectins stand out as key molecules in the regulation of cell adhesion, proliferation, apoptosis, immunity, and inflammation, perf…
During pregnancy, the transfer of factors and antibodies across the placenta is essential to provide protection to the baby. However, there is limited knowledge regarding the antibody repertoire of pregnant women, especially in pregnant women infected with HIV, under antiretroviral treatment. This study aims to comprehensively evaluate the repertoire of antibodies against all viruses in p…
DNA vaccines are safety and stable gene expression vectors, with easy design of genetic sequences, which allows molecular manipulation to ensure improved immunogenicity. However, naked plasmids present limitations that can compromise their effectiveness. We previously developed an optimized DNA vaccine to Zika virus (ZIKV) consisting of the DNA sequence coding for the viral antigens carri…
Allergy is a common syndrome that affects around around 1 billion people worldwide, with an increasing prevalence. The most common allergic manifestations are allergic rhinitis, atopic dermatitis, food allergy and allergic asthma. Allergy is mainly characterized by a type 2 immune response, with the differentiation of T helper (Th) cells into Th2 and high production of IgE. Although much …
| 2 / 2 | Ongoing grants |
| 23 / 12 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 49 / 18 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 83 / 41 | All research grants and scholarships |
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