João Luis Callegari Lopes

• Abstract

  The identification and quantification of impurities in the production process, or even resulting from the stability of drugs and medicines, comprise an extremely important stage of the drug research and development process. In this context, one of the factors that greatly impacted pharmaceutical laboratories in recent years was the need to comply with Anvisa's RDC No. 53/2015, which regul…

  Development of a platform for the synthesis and analytical certification of nitrosamines of pharmaceutical interest, AP.PIPE

• Abstract

  The Asteraceae family comprises 17 tribes among which Vernonieae tribe. Vernonieae shows a pantropical distribution, but some genus presents a high degree of endemism. Lychnophora ericodes Mart, populary known as "arnicado Brazil", "arnica - da-serra" or "false - arnica", is the most used medicinal plant from Vernonieae tribe in Brazil. These specie presents microendemism at the high alti…

  Dinamics of the metabolism of the secondary metabolites from Asteraceae species biologically active through classical and recents mass spectrometric techniques and the poyencially developing of topical formulations for antinflammatory and analgesic use, AP.BTA.R
• Analysis of secondary metabolism rhythms in species of the Vernoieae (Asteraceae) tribe., AP.R

(Only some records are available in English at this moment)

• Development of a platform for the synthesis and analytical certification of nitroamines of pharmaceutical interest, BP.TT

• Abstract

  Inhibitors of HIV-1 protease are designed to, generally, act specifically on this enzyme class, characterized by its high affinity and high complementarity to the catalytic site of the protein, intrinsically competing with the natural substrates. The goal of antiretroviral therapy is therefore to slow the progression of immunodeficiency and restore, as much as possible, immunity, increasi…

  Application of green chemistry strategies for the preparation of tenofovir disoproxil fumarate, BP.PD

• Abstract

  The market of herbal medicines in Brazil is significantly growing and the Federal Government is implementing a series of measures aimed at their research and development. One of these measures is the publication of RENISUS (a list of medicinal plants of interest to Brazilian public health), in which species with potential to advance in stages of production and generate products of interes…

  Evaluation of alkaloids metabolism of Erythrina verna, BP.PD

(Only some records are available in English at this moment)