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Dinamics of the metabolism of the secondary metabolites from Asteraceae species biologically active through classical and recents mass spectrometric techniques and the poyencially developing of topical formulations for antinflammatory and analgesic use


The Asteraceae family comprises 17 tribes among which Vernonieae tribe. Vernonieae shows a pantropical distribution, but some genus presents a high degree of endemism. Lychnophora ericodes Mart, populary known as "arnicado Brazil", "arnica - da-serra" or "false - arnica", is the most used medicinal plant from Vernonieae tribe in Brazil. These specie presents microendemism at the high altitude of the Brazilian cerrado, more specifically in the states of Minas Gerais, Goiás and the Federal District, but can be also found at São Paulo State at Franca cerrado. The false arnica is the most widely used in folk medicine among the species of the genus, in the form of hydroalcoholic extract to treat inflammation. Essential oils from the leaves of L. ericides present a great diversity of secondary metabolites belonging to the class of terpenes and exhibit various biological activities, including cytotoxic for strains of B16 human melanoma cells according to the latest tests conducted by our research group (unpublished data). The literature indicates occurrence of derivatives bisabolanos in essential oils of L ericoides, like bisabolol, a hydroxy - bisabolene. This project proposes to investigate the levels of these compounds in five different populations, to determine which of these populations has the greatest ability to produce in quantity and structural diversity of these sesquiterpenes. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DEMARQUE, DANIEL P.; CROTTI, ANTONIO E. M.; VESSECCHI, RICARDO; LOPES, JOAO L. C.; LOPES, NORBERTO P.. Fragmentation reactions using electrospray ionization mass spectrometry: an important tool for the structural elucidation and characterization of synthetic and natural products. NATURAL PRODUCT REPORTS, v. 33, n. 3, p. 432-455, . (14/20302-4, 13/20094-0, 14/23604-1, 14/50265-3, 14/18052-0)

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