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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fragmentation reactions using electrospray ionization mass spectrometry: an important tool for the structural elucidation and characterization of synthetic and natural products

Full text
Author(s):
Demarque, Daniel P. [1] ; Crotti, Antonio E. M. [2] ; Vessecchi, Ricardo [2] ; Lopes, Joao L. C. [1] ; Lopes, Norberto P. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Quim & Fis, Fac Ciencias Farmaceut Ribeirao Preto, Av Cafe S-N, BR-14049 Ribeirao Preto, SP - Brazil
[2] Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: NATURAL PRODUCT REPORTS; v. 33, n. 3, p. 432-455, 2016.
Web of Science Citations: 99
Abstract

Over the last decade, the number of studies reporting the use of electrospray ionization mass spectrometry (ESI-MS) in combination with collision cells (or other activation methods) to promote fragmentation of synthetic and natural products for structural elucidation purposes has considerably increased. However, the lack of a systematic compilation of the gas-phase fragmentation reactions subjected to ESI-MS/MS conditions still represents a challenge and has led to many misunderstood results in the literature. This review article exploits the most common fragmentation reactions for ions generated by ESI in positive and negative modes using collision cells in an effort to stimulate the use of this technique by non-specialists, undergraduate students and researchers in related areas. (AU)

FAPESP's process: 13/20094-0 - Evaluation of the anti-parasitary and insecticidal activities of benzofuran derivatives, and study of their gas-phase fragmentation reactions using tandem mass spectrometry
Grantee:Antônio Eduardo Miller Crotti
Support Opportunities: Regular Research Grants
FAPESP's process: 14/23604-1 - Computational chemistry: a tool to studies of mass spectrometry, reactivity and fragmentation/reaction mechanisms of organic compounds
Grantee:Ricardo Vessecchi Lourenço
Support Opportunities: Regular Research Grants
FAPESP's process: 14/20302-4 - Dinamics of the metabolism of the secondary metabolites from Asteraceae species biologically active through classical and recents mass spectrometric techniques and the poyencially developing of topical formulations for antinflammatory and analgesic use
Grantee:João Luis Callegari Lopes
Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants
FAPESP's process: 14/18052-0 - Tissue localization of tannins and Anthraquinones acting on gastrointestinal system
Grantee:Daniel Pecoraro Demarque
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/50265-3 - Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation
Grantee:Norberto Peporine Lopes
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants