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Identification of adulterations and simultaneous determination of nutrients and contaminants in food using direct analysis mass spectrometry and imaging

Grant number: 14/00084-2
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2014
Effective date (End): February 28, 2017
Field of knowledge:Agronomical Sciences - Food Science and Technology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Rodrigo Ramos Catharino
Grantee:Diogo Noin de Oliveira
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The urge for faster and highly-efficient analytical methods is the driveforce in food research. Metabolomics is a versatile platform which integrates both statistical and experimental data, providing highly-reliable analytical results. Along with the modern mass spectrometric techniques, there is a very prominent scenario for the development of new and improved approaches. In this project, samples of various functional food products, such as olive oil, peanuts and chocolate will be directly analyzed through conventional mass spectrometry (MS) and mass spectrometry imaging (MSI), with little sample preparation. Chemical characterization and adulteration processes will be monitored within this scope. Ionization sources, such as matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI) will be largely explored in this context. Structural elucidations will be performed with the assistance of high-resolution mass spectrometry (ESI-Orbitrap). Chemical markers can be previously elected for a targeted analysis or identified after the analytical process, as in metabolic fingerprinting. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre a bolsa:
Novel method facilitates quantification of active pharmaceutical ingredients 
Study warns that heating sucralose can be dangerous 

Scientific publications (13)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, DIOGO N.; CAMARGO, ANA C. B.; MELO, CARLOS F. O. R.; CATHARINO, RODRIGO R. A fast semi-quantitative screening for cocoa content in chocolates using MALDI-MSI. Food Research International, v. 103, p. 8-11, JAN 2018. Web of Science Citations: 0.
BUSANELLO, ESTELA N. B.; MARQUES, ANA C.; LANDER, NOELIA; DE OLIVEIRA, DIOGO N.; CATHARINO, RODRIGO R.; OLIVEIRA, HELENA C. F.; VERCESI, ANIBAL E. Pravastatin Chronic Treatment Sensitizes Hypercholesterolemic Mice Muscle to Mitochondrial Permeability Transition: Protection by Creatine or Coenzyme Q(10). FRONTIERS IN PHARMACOLOGY, v. 8, APR 5 2017. Web of Science Citations: 14.
ODIR RODRIGUES MELO, CARLOS FERNANDO; ESTEVES, CIBELE ZANARDI; DE OLIVEIRA, ROSIMEIRE NUNES; GUERREIRO, TATIANE MELINA; DE OLIVEIRA, DIOGO NOIN; LIMA, ESTELA DE OLIVEIRA; MINE, JULIO CESAR; ALLEGRETTI, SILMARA MARQUES; CATHARINO, RODRIGO RAMOS. Early developmental stages of Ascaris lumbricoides featured by high-resolution mass spectrometry. Parasitology Research, v. 115, n. 11, p. 4107-4114, NOV 2016. Web of Science Citations: 1.
VIVIAN, ADRIANA FU; AOYAGUI, CAROLINE TIEMI; DE OLIVEIRA, DIOGO NOIN; CATHARINO, RODRIGO RAMOS. Mass spectrometry for the characterization of brewing process. Food Research International, v. 89, n. 1, p. 281-288, NOV 2016. Web of Science Citations: 4.
ODIR RODRIGUES MELO, CARLOS FERNANDO; DE OLIVEIRA, DIOGO NOIN; LIMA, ESTELA DE OLIVEIRA; GUERREIRO, TATIANE MELINA; ESTEVES, CIBELE ZANARDI; BECK, RAISSA MARQUES; PADILLA, MARINA AIELLO; MILANEZ, GUILHERME PAIER; ARNS, CLARICE WEIS; PROENCA-MODENA, JOSE LUIZ; SOUZA-NETO, JAYME AUGUSTO; CATHARINO, RODRIGO RAMOS. A Lipidomics Approach in the Characterization of Zika-Infected Mosquito Cells: Potential Targets for Breaking the Transmission Cycle. PLoS One, v. 11, n. 10 OCT 10 2016. Web of Science Citations: 15.
DE MENEZES, MAICO; DE OLIVEIRA, DIOGO NOIN; CATHARINO, RODRIGO RAMOS. Capillary-induced Homogenization of Matrix in Paper: A Powerful Approach for the Quantification of Active Pharmaceutical Ingredients Using Mass Spectrometry Imaging. SCIENTIFIC REPORTS, v. 6, JUL 21 2016. Web of Science Citations: 2.
FERREIRA, MONICA SIQUEIRA; DE OLIVEIRA, DIOGO NOIN; MESQUITA, CAROLINE COSTA; DE LIMA BARBOSA, ANA PAULA; ANHE, GABRIEL FORATO; CATHARINO, RODRIGO RAMOS. MALDI-MSI: a fast and reliable method for direct melatonin quantification in biological fluids. JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, v. 7, 2016. Web of Science Citations: 0.
DOS SANTOS, GUSTAVO APARECIDO; FERREIRA, MONICA SIQUEIRA; DE OLIVEIRA, DIOGO NOIN; DE OLIVEIRA, VANESSA; SIQUEIRA-SANTOS, EDILENE S.; CORREA CINTRA, DENNYS ESPER; CASTILHO, ROGER FRIGERIO; VELLOSO, LICIO AUGUSTO; CATHARINO, RODRIGO RAMOS. Identification of compounds from high-fat and extra virgin olive oil-supplemented diets in whole mouse liver extracts and isolated mitochondria using mass spectrometry. Journal of Mass Spectrometry, v. 50, n. 7, p. 951-958, JUL 2015. Web of Science Citations: 4.
DE OLIVEIRA, DIOGO N.; DE MENEZES, MAICO; CATHARINO, RODRIGO R. Thermal degradation of sucralose: a combination of analytical methods to determine stability and chlorinated byproducts. SCIENTIFIC REPORTS, v. 5, APR 15 2015. Web of Science Citations: 9.
DE OLIVEIRA, DIOGO NOIN; DELAFIORI, JEANY; FERREIRA, MONICA SIQUEIRA; CATHARINO, RODRIGO RAMOS. In vitro evaluation of Sun Protection Factor and stability of commercial sunscreens using mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 988, p. 13-19, APR 15 2015. Web of Science Citations: 1.
DE OLIVEIRA, D. N.; CATHARINO, R. R. Direct metabolic fingerprinting of olive oils using STELDI-MS. Journal of Food Composition and Analysis, v. 38, p. 131-134, MAR 2015. Web of Science Citations: 7.
DAMARIO, NATALIA; DE OLIVEIRA, DIOGO N.; FERREIRA, MONICA S.; DELAFIORI, JEANY; CATHARINO, RODRIGO R. Cheese lipid profile using direct imprinting in glass surface mass spectrometry. ANALYTICAL METHODS, v. 7, n. 6, p. 2877-2880, 2015. Web of Science Citations: 1.
GUERREIRO, TATIANE MELINA; DE OLIVEIRA, DIOGO NOIN; FERREIRA, MONICA SIQUEIRA; CATHARINO, RODRIGO RAMOS. High-throughput analysis by SP-LDI-MS for fast identification of adulterations in commercial balsamic vinegars. Analytica Chimica Acta, v. 838, p. 86-92, AUG 1 2014. Web of Science Citations: 12.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
OLIVEIRA, Diogo Noin de. The development of modern mass spectrometry techniques for the analysis of beneficial and toxic bioactive compounds in food. 2017. Doctoral Thesis - Universidade Estadual de Campinas, Faculdade de Ciências Médicas.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.

Filed patent(s) as a result of this research project

MÉTODO DE IDENTIFICAÇÃO DE BIOMARCADORES PARA COLESTASE NEONATAL, KIT DE IDENTIFICAÇÃO DOS BIOMARCADORES E USO PCT/BR2017/000151 - Universidade Estadual de Campinas (UNICAMP) . Rodrigo Ramos Catharino; Maria Angela Bellomo Brandao; Gabriel Hessel; Letícia de Aguiar Dias; Carlos Fernando Odir Rodrigues Melo; Diogo Noin de Oliveira (FCM); Cibele Zanardi Esteves - December 2017, 19