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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Lipidomics Approach in the Characterization of Zika-Infected Mosquito Cells: Potential Targets for Breaking the Transmission Cycle

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Odir Rodrigues Melo, Carlos Fernando ; de Oliveira, Diogo Noin ; Lima, Estela de Oliveira ; Guerreiro, Tatiane Melina ; Esteves, Cibele Zanardi ; Beck, Raissa Marques ; Padilla, Marina Aiello ; Milanez, Guilherme Paier ; Arns, Clarice Weis ; Proenca-Modena, Jose Luiz ; Souza-Neto, Jayme Augusto ; Catharino, Rodrigo Ramos
Total Authors: 12
Document type: Journal article
Source: PLoS One; v. 11, n. 10 OCT 10 2016.
Web of Science Citations: 13
Abstract

Recent outbreaks of Zika virus in Oceania and Latin America, accompanied by unexpected clinical complications, made this infection a global public health concern. This virus has tropism to neural tissue, leading to microcephaly in newborns in a significant proportion of infected mothers. The clinical relevance of this infection, the difficulty to perform accurate diagnosis and the small amount of data in literature indicate the necessity of studies on Zika infection in order to characterize new biomarkers of this infection and to establish new targets for viral control in vertebrates and invertebrate vectors. Thus, this study aims at establishing a lipidomics profile of infected mosquito cells compared to a control group to define potential targets for viral control in mosquitoes. Thirteen lipids were elected as specific markers for Zika virus infection (Brazilian strain), which were identified as putatively linked to the intracellular mechanism of viral replication and/or cell recognition. Our findings bring biochemical information that may translate into useful targets for breaking the transmission cycle. (AU)

FAPESP's process: 13/11343-6 - Characterization of the microbiota-mediated anti-dengue mechanisms in wild Aedes aegypti populations
Grantee:Jayme Augusto de Souza-Neto
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 14/00084-2 - Identification of adulterations and simultaneous determination of nutrients and contaminants in food using direct analysis mass spectrometry and imaging
Grantee:Diogo Noin de Oliveira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/00302-0 - Lipidomics shotgun in giardiasis, meningitis and tuberculosis: the search of diagnostic markers, using revolutionary new techniques of mass spectrometry
Grantee:Cibele Zanardi Esteves
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/50400-0 - Mitochondrial energy metabolism, redox state and functionality in cell death and cardiometabolic and neurodegenerative disorders
Grantee:Aníbal Eugênio Vercesi
Support type: Research Projects - Thematic Grants
FAPESP's process: 15/06809-1 - Determination of chemical markers in various bovine products using mass spectrometry
Grantee:Rodrigo Ramos Catharino
Support type: Regular Research Grants