Acquisition of a mass spectrometer for the generation of images at the Mass Spectr...
| Full text | |
| Author(s): |
de Menezes, Maico
;
de Oliveira, Diogo Noin
;
Catharino, Rodrigo Ramos
Total Authors: 3
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 6, JUL 21 2016. |
| Web of Science Citations: | 1 |
| Abstract | |
Herein we present a novel approach for the quantification of active pharmaceutical ingredients (APIs) using mass spectrometry imaging. This strategy uses a filter paper previously ``eluted{''} with a MALDI matrix solution as a support for analyte application. Samples are submitted to mass spectrometry imaging (MSI) and quantification through characteristic fingerprints is ultimately performed. Results for the content of rosuvastatin from a known formulation are comparable to those obtained with a validated HPLC method. (AU) | |
| FAPESP's process: | 14/00084-2 - Identification of adulterations and simultaneous determination of nutrients and contaminants in food using direct analysis mass spectrometry and imaging |
| Grantee: | Diogo Noin de Oliveira |
| Support type: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 11/50400-0 - Mitochondrial energy metabolism, redox state and functionality in cell death and cardiometabolic and neurodegenerative disorders |
| Grantee: | Aníbal Eugênio Vercesi |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 15/06809-1 - Determination of chemical markers in various bovine products using mass spectrometry |
| Grantee: | Rodrigo Ramos Catharino |
| Support type: | Regular Research Grants |