| Full text | |
| Author(s): |
Mauriz Marques, Lucas Maciel
[1, 2]
;
Aguiar, Fernando Armani
[2]
;
da Silva, Denise Brentan
[1, 2]
;
Callejon, Daniel Roberto
[1]
;
Moraes de Oliveira, Anderson Rodrigo
[3]
;
Lopes, Norberto Peporine
[2]
;
Callegari Lopes, Joao Luis
[2]
;
Guaratini, Thais
[1, 2]
Total Authors: 8
|
| Affiliation: | [1] Lychnoflora Pesquisa & Desenvolvimento Prod Nat L, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Nucleo Pesquisa Prod Nat & Sintet, BR-14049 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 25, n. 5, p. 529-532, SEP-OCT 2015. |
| Web of Science Citations: | 1 |
| Abstract | |
ABSTRACTThe genus Erythrina, Fabaceae, is widely distributed in tropical and subtropical regions. Their flowers, fruits, seeds and bark are frequently used in folk medicine for its effects on the central nervous system such as anticonvulsant, antidepressant, analgesic, sedative, and hypnotic effects. Erythraline has been reported as one of the active compounds from Erythrina, but until now there are no pharmacokinetics data about this compound and only few results showing a putative metabolism were reported. To improve the information about erythraline metabolism, this article reports and discusses, for the first time, the in vitrometabolism biotransformation of erythraline by cytochrome P450 enzymes. (AU) | |
| FAPESP's process: | 09/51812-0 - Development of a platform for the study of in vitro and in vivo metabolism of natural products, a need for pre-clinical testing system |
| Grantee: | Norberto Peporine Lopes |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 14/20302-4 - Dinamics of the metabolism of the secondary metabolites from Asteraceae species biologically active through classical and recents mass spectrometric techniques and the poyencially developing of topical formulations for antinflammatory and analgesic use |
| Grantee: | João Luis Callegari Lopes |
| Support Opportunities: | BIOTA-FAPESP Program - Regular Research Grants |
| FAPESP's process: | 12/18031-7 - Application of MALDI-MS/MS in the vicenin-2 and derivatives analyses: Understanding the ionization processes to production of the images |
| Grantee: | Denise Brentan da Silva |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 11/13281-2 - Evaluation of alkaloids metabolism of Erythrina verna |
| Grantee: | Thais Guaratini |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 14/50265-3 - Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation |
| Grantee: | Norberto Peporine Lopes |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |