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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Microsomal metabolism of erythraline: an anxiolitic spiroalkaloid

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Mauriz Marques, Lucas Maciel [1, 2] ; Aguiar, Fernando Armani [1] ; da Silva, Denise Brentan [2, 1] ; Callejon, Daniel Roberto [2] ; Moraes de Oliveira, Anderson Rodrigo [3] ; Lopes, Norberto Peporine [1] ; Callegari Lopes, Joao Luis [1] ; Guaratini, Thais [1, 2]
Total Authors: 8
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Nucleo Pesquisa Prod Nat & Sintet, BR-14049 Ribeirao Preto, SP - Brazil
[2] Lychnoflora Pesquisa & Desenvolvimento Prod Nat L, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 1

The genus Erythrina, Fabaceae, is widely distributed in tropical and subtropical regions. Their flowers, fruits, seeds and bark are frequently used in folk medicine for its effects on the central nervous system such as anticonvulsant, antidepressant, analgesic, sedative, and hypnotic effects. Erythraline has been reported as one of the active compounds from Erythrina, but until now there are no pharmacokinetics data about this compound and only few results showing a putative metabolism were reported. To improve the information about erythraline metabolism, this article reports and discusses, for the first time, the in vitro metabolism biotransformation of erythraline by cytochrome P450 enzymes. (C) 2015 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved. (AU)

FAPESP's process: 14/50265-3 - Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation
Grantee:Norberto Peporine Lopes
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 09/51812-0 - Development of a platform for the study of in vitro and in vivo metabolism of natural products, a need for pre-clinical testing system
Grantee:Norberto Peporine Lopes
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 14/20302-4 - Dinamics of the metabolism of the secondary metabolites from Asteraceae species biologically active through classical and recents mass spectrometric techniques and the poyencially developing of topical formulations for antinflammatory and analgesic use
Grantee:João Luis Callegari Lopes
Support type: BIOTA-FAPESP Program - Regular Research Grants
FAPESP's process: 12/18031-7 - Application of MALDI-MS/MS in the vicenin-2 and derivatives analyses: Understanding the ionization processes to production of the images
Grantee:Denise Brentan da Silva
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/13281-2 - Evaluation of alkaloids metabolism of Erythrina verna
Grantee:Thais Guaratini
Support type: Scholarships in Brazil - Post-Doctorate