Abstract
Loss of function of fragile messenger ribonucleoprotein (FMRP), encoded by the FMR1 gene, leads to fragile X syndrome, the commonest inherited cause of intellectual disability among men. FMRP is an RNA-binding protein, mostly found in ribosomes and stress granules, with well-established roles in mRNA translation regulation in neurogenesis and synaptogenesis. FMRP is expressed as a group o…