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Expression analysis of FMR1 splicing products

Grant number: 19/10868-4
Support type:Regular Research Grants
Duration: November 01, 2019 - October 31, 2021
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Luciana Amaral Haddad
Grantee:Luciana Amaral Haddad
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Carla Columbano de Oliveira ; Luis Eduardo Soares Netto ; Lygia da Veiga Pereira

Abstract

Fragile mental retardation protein (FMRP), encoded by the FMR1 gene, has been detected in pre- and postsynaptic neuronal processes. It plays central roles in translational repression of several dendritic mRNAs, which have translation activated upon synaptic stimulation, notably by glutamate. Other DNA- and RNA-mediated roles have been assigned to FMRP. Different FMRP isoforms have been proposed due to FMR1 transcript alternative splicing and protein electrophoretic gel mobility variations. However, a limited number of specific functional roles have been experimentally demonstrated for FMRP isoforms. In this proposal, we aim to understand the generation of functional diversity by FMR1 alternative splicing. (AU)