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Expression analysis of FMR1 splicing products

Grant number: 19/10868-4
Support Opportunities:Regular Research Grants
Start date: November 01, 2019
End date: March 31, 2022
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Luciana Amaral Haddad
Grantee:Luciana Amaral Haddad
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Carla Columbano de Oliveira ; Luis Eduardo Soares Netto ; Lygia da Veiga Pereira

Abstract

Fragile mental retardation protein (FMRP), encoded by the FMR1 gene, has been detected in pre- and postsynaptic neuronal processes. It plays central roles in translational repression of several dendritic mRNAs, which have translation activated upon synaptic stimulation, notably by glutamate. Other DNA- and RNA-mediated roles have been assigned to FMRP. Different FMRP isoforms have been proposed due to FMR1 transcript alternative splicing and protein electrophoretic gel mobility variations. However, a limited number of specific functional roles have been experimentally demonstrated for FMRP isoforms. In this proposal, we aim to understand the generation of functional diversity by FMR1 alternative splicing. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CORREA-VELLOSO, JULIANA C.; LINARDI, ALESSANDRA M.; GLASER, TALITA; VELLOSO, FERNANDO J.; RIVAS, MARIA P.; LEITE, RENATA E. P.; GRINBERG, LEA T.; ULRICH, HENNING; AKINS, MICHAEL R.; CHIAVEGATTO, SILVANA; et al. Fmr1 exon 14 skipping in late embryonic development of the rat forebrain. BMC NEUROSCIENCE, v. 23, n. 1, p. 15-pg., . (18/07366-4, 17/06100-8, 19/10868-4, 11/14329-9, 09/01333-8)