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Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Claudia Elisabeth Munte in research grants and scholarships supported by FAPESP.
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Lipidic microdomains are specific regions in biological membranes characterized by areas rich in saturated phospholipids, sphingolipids and cholesterol. These environments play important regulatory roles in living cells, including the transport of molecules and signal transduction. While several normal proteins are found to these areas, such as Caveolins and TNFR-1, microdomains are also …
Cell invasion by the different infective forms of Trypanosoma cruzi, the causative parasite of Chagas disease, involves several mechanisms which culminate in entry of T. cruzi into host cells. Numerous studies have been conducted in order to identify surface proteins related to cell invasion, but mostly from metacyclic and tissue culture trypomastigotes forms. However, little attention h…
Cystatins are inhibitors of cysteine proteases. The majority are only weak inhibitors of human cathepsin B, which has been associated with cancer, Alzheimer's disease and arthritis. Starting from the sequences of oryzacystatin-1 and canecystatin-1, a hybrid clone was recently obtained, which presented higher inhibitory activity towards cathepsin B. This clone presented two unanticipated …
This project aims to solve the tridimensional structure of the P21 protein of T. cruzi using multidimensional, high-resolution NMR spectroscopy, and to investigate its interaction with the CXCR4 chemokine receptor. To achieve this goal, the NMR spectra necessary to finalize the complete assignments, and the required NOESY-type spectra for structure calculation we will acquired in an 800 M…
The main histological feature in Alzheimer's disease is the presence of amyloid plaques in patient's brain. The most abundant element of these plaques is the beta-amyloid peptide (Abeta). The peptide is produced through a proteolytic cleavage of the amyloid precursor protein (APP), resulting predominantly in the Abeta(1-40) and Abeta(1-42) forms, the latter being the more toxic species. I…
The main histological feature in Alzheimer's disease is the presence of amyloid plaques in patient's brain. The most abundant element of these plaques is the beta-amyloid peptide (Abeta). The peptide is produced through a proteolytic cleavage of the amyloid precursor protein. Initially soluble and with a helical tendency, the peptide assembles into oligomers, that are the primary toxic sp…
| 2 / 1 | Completed research grants |
| 4 / 2 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 9 / 6 | All research grants and scholarships |
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