Abstract
Study of the immunogenicity of outer membrane antigens of Neisseria meningitidis and interaction with cationic lipids: evaluation of new adjuvant for Neisseria meningitidis in different strains of elderly mice. (AU)
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Elizabeth Natal de Gaspari
CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Coordenadoria de Controle de Doenças (CCD). Instituto Adolfo Lutz (IAL) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Scientific Researcher VI at the Immunology Center of the Adolfo Lutz Institute. Graduated in BioMedicine from the University of Santo Amaro (1978), Master in Microbiology and Immunology from Escola Paulista and Instituto Butantan (1979-1983), PhD in Immunology from the Department of Immunology at the University of São Paulo (1990). Post-doctoral research associate in Monoclonal Antibodies and Vaccines at the Walter Reed Army Institute of Research (USA) Bacterial Disease (USA) (1991). Expertise : Emergency Preparedness and Response Centre, Health Protection Agency, Porton Down, Salisbury, UK, Kansas State University (USA), Institute of Cell Biology, Swiss Federal Institute of Technology, Departments of Microbiology, Medical University of Alabama (USA), Department of Immunology, University of São Paulo (Brazil) and Butantan Institute of WHO/PAHO/SP (Brazil). He currently leads a research group that focuses on the evaluation of immune responses and new vaccine preparations, particularly the interaction of cells, antibodies and adjuvants,. (Source: Lattes Curriculum)
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Research grants
- Study of the immunogenicity of outer membrane antigens of Neisseria meningitidis and interaction with cationic lipids: evaluation of new adjuvant for Neisseria meningitidis in different strains of elderly mice, AP.R
- Study of the immunogenicity of outer membrane antigens of Neisseria meningitidis and interaction with cationic lipids: evaluation of different immunization schedules in different strains of mice, AP.R
Abstract
The meningococcal vaccines have been shown effective against serogroups A and C, but still there is no vaccine against serogroup B due to the similarities between the structure and the B capsular polysaccharide acid polisiálico part of the human brain tissue, can lead to autoimmune diseases. The objective of this study is to investigate the properties of a new preparation with outer membr…
- The design of new adjuvants for mucosal immunity to neisseria meningitidis b in nasaly primed neonate mice for a strong adult immune response., AR.EXT
(Only some records are available in English at this moment)
Scholarships in Brazil
- Evaluation of response profiles of Th1 and Th2 in mice immunized with anionic and cationic lipids complexed the outer membrane vesicles of Neisseria meningitis b, BP.MS
Abstract
The growing demand for the development of new adjuvants is guided in order to powerful action and non-toxic, and still with the ability to modulate cellular responses (Th1) in addition to the already obtained (Th2).Here we propose the study of the immune response induced by antigenic preparations of outer membrane vesicles (OMVs) of Neisseria meningitidis serogroup B' with the cationic li…
- Comparative study of ELISA and ELISPOT techniques in the detection of antibodies IgG, IgM in isogenic strains of elderly mice, BP.IC
Abstract
This proposal aims to assess the immunogenicity of the antigenic preparations based on OMVs of Neisseria meningitidis B complexed to two different adjuvants, the cationic lipid DODAB-BF and aluminum hydroxide in elderly mice immunized by subcutaneous injection. We will used isogenic mice female BALB/c and/Sn with approximately 360 days of life.To characterize the interaction of antigens …
- Study of the immunogenicity of outer membrane antigens of Neisseria meningitidis and interaction with cationic lipids: evaluation of different immunization schedules in different strains of mice, BP.MS
Abstract
The meningococcal vaccines have been shown effective against serogroups A and C, but still there is no vaccine against serogroup B due to the similarities between the structure and the B capsular polysaccharide acid polisiálico part of the human brain tissue, can lead to autoimmune diseases. The objective of this study is to investigate the properties of a new preparation with outer membr…
Total / Available in English
| 14 / 9 | Completed research grants |
| 7 / 3 | Completed scholarships in Brazil |
| 21 / 12 | All research grants and scholarships |
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