Abstract
N-Acetyl-L-aspartate (NAA) and its product N-acetylaspartylglutamate (NAAG) are among the most important brain metabolites. NAA is a marker of neurons integrity and viability, while NAAG modulates glutamate release and may have a role in neuroprotection and synaptic plasticity. Investigating, on quantitative basis, the role of these metabolites in brain metabolism in vivo by MRS is a majo…