CV Lattes
ResearcherID
ORCID
Google Scholar Citations
Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Farmácia Industrial from Universidade de São Paulo (1991), master's at Genetics from Universidade de São Paulo (1997) and doctorate at Tecnologia Bioquímica Farmacêutica from Universidade de São Paulo (2002). Has experience in Pharmacy, acting on the following subjects: vacinas, streptococcus pneumoniae, cultivo submerso, polissacarídeos capsulares and downstream processing. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
The development of bioprocesses for production of vaccines and other molecules of biotechnological interest involves several stages from the construction and/or selection of the producer clone to the establishment of cultivation conditions in a bioreactor. After the tedious and critical step of clone selection, one of the most time-consuming steps is the culture medium optimization, norma…
Our studies have demonstrated the advantages of Mycobacterium bovis BCG as an antigen presenting system in the development of new vaccines. The project aims to expand the use of methods of heterologous gene expression in BCG developed in our laboratories with the aim of proposing new vaccines in the immunization against Pertussis, Tuberculosis, Pneumococcus and Schistosome, and to improve…
Streptococcus pneumoniae utilizes as a portal of entry into the body causing community acquired-pneumonia (CAP), bacteraemia, meningitis and sepsis (invasive pneumococcal disease, IPD). Current pneumococcal conjugate vaccine (PCV13) comprises 13 of the most common S. pneumoniase serotypes and is administered via the parental route resulting in low levels of lung mucosal immunity. Several …
(Only some records are available in English at this moment)
Recombinant proteins from Streptococcus pneumoniae have been evaluated as novel serotype-independent vaccines to overcome the limitations of current conjugate vaccines, which provide protection limited to the polysaccharide serotypes included in the formulations, typically covering only 20 out of >100 known serotypes. Recombinant pneumococcal proteins were produced in Escherichia coli and…
Schistosomiasis is a neglected tropical disease and one of the most important parasitosis in the world, currently endemic in more than 50 countries and responsible for over 11,000 deaths per year, besides other socioeconomic impacts. For Schistosoma mansoni, prevalent parasite species in Brazil, SmTSP-2 and SmCD59.2 antigens in fusion with rhizavidin stand out for the development of vacci…
Streptococcus pneumoniae can cause a series of human infections leading to multiple health hazards, such as pneumonia, meningitis, bacteremia and sepsis. Pneumococcal vaccines currently on the market are based on polysaccharides and have limited coverage against the nearly 100 serotypes described. Although polysaccharide-based vaccines are important in preventing disease and decreasing th…
Tuberculosis (TB) is the leading cause of death in the world from a single infectious agent and the largest responsible for the death of people with HIV. The first human vaccination for TB was applied in Paris in 1921 using an attenuated strain called bacillus Calmette-Guérin (BCG). More than a hundred years after its development, the BCG vaccine is still the preferred prophylactic option…
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and is one of the main causes of death in the world. The attenuated live vaccine produced with the Calmette-Guérin bacillus (BCG) is the only one available against human TB and it is administrated as one dose on birth. However, BCG has low efficiency against pulmonary TB in adolescents and adults, and for this…
Zika Vírus (ZIKV) is an arbovirus that belongs to the Flaviviridae family and Flavivirus genus. It is capable of infecting humans and causing neurological complications, including Guillain-Barré Syndrome and Microcephaly. The main function of ZIKV envelope E protein is the interaction with cell receptors to promote the fusion between viral envelope and host cell membrane. The E protein is…
(Only some records are available in English at this moment)
Young children, older individuals and immune-compromised individuals are at greater risk of developing pneumonia caused by the bacterium Streptococcus pneumoniae (pneumococcus). At any given time, approximately 10-20% of adults are colonized with pneumococcus in the upper respiratory tract but colonization with the bacterium does not cause any symptoms. However, when immune defense mechan…
EDIII is the most exposed region of Zika Virus E protein and evokes potentneutralizing antibodies. It has the required characteristics to be used as a safe andeffective antigen for a subunit Zika vaccine. EDIII production in E. coli has beenreported only at lab-scale and mostly refolded from inclusion bodies (IB), which isdifficult to scale-up maintaining protein function. Fusion tag tech…
| 2 / 2 | Ongoing grants |
| 7 / 5 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 9 / 8 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 23 / 20 | All research grants and scholarships |
| Associated processes | |