CV Lattes
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Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Frank Nelson Crespilho is a Brazilian chemist, born in the countryside of São Paulo, with a career dedicated to the intersection of bioelectrochemistry, sustainable energy, and health. He graduated from the University of São Paulo (USP), where he also earned his master's, PhD, and habilitation (livre-docência), establishing an interdisciplinary research path with a strong focus on integrating biological systems with electroactive materials. His academic journey includes training and international collaborations at prestigious institutions such as the University of Coimbra (Portugal), California Institute of Technology Caltech (USA), Max Planck Institute for Solid State Research (Germany), Harvard University (USA), and the University of Minho (Portugal). Over the past two decades, Crespilho has led research projects across multiple scientific fronts, with notable contributions to the development of implantable biochips, bio-batteries, and the conceptualization of Three-Dimensional Catalysis, published in Nature Communications. During the COVID-19 pandemic, he led a rapid-response initiative in molecular diagnostics, with national impact and transdisciplinary collaborations. Beyond his scientific work, he has played an active role in mentoring and training the next generation of researchers, having supervised more than 60 undergraduate and graduate students. He is the author of scientific books and holds patents in the fields of bioelectronics and diagnostics. His work has been recognized with several national and international awards, including the Kurt Politzer Innovation Award and the Electrochimica Acta Travel Award for Young Electrochemists, granted by the International Society of Electrochemistry. He has published over 140 peer-reviewed articles, which have received more than 5,000 citations. Crespilho was named among the top 2 most influential scientists in the world, according to a ranking by Stanford University (USA), reflecting the lasting impact of his contributions to science and technolog (Source: Lattes Curriculum)
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The edge of graphene has long attracted special attention due to its distinct physical and chemical properties in contrast to the graphitic basal plane. Electrochemistry at an isolated graphene edge (GrEdge) electrode has been systematically studied recently. We have shown that we can achieve high mass transport rates for electroactive species at the one-dimensional edge, which has enable…
Grand challenges such as the fabrication of sensing devices for early diagnosis of cancer and detection of food/water contamination can only be addressed with concerted efforts in multidisciplinary research. Selected problems within the above challenges will be tackled in this Project by a multiinstitutional team of physicists, chemists, engineers, medical doctors and computer scientists,…
The production of value-added products from enzymes or redox proteins found in nature is limited. This limitation can be overcome in the laboratory by modifying native enzymes, or by obtaining artificial apo-reconstituted proteins. In this project, we intend to contribute to frontier research in the area of metalloprotein bioengineering and to obtain new apo-reconstituted structures. Thus…
Redox processes play a critical role in maintaining life on Earth, and they are facilitated by biomolecules. In 2020, we described in Nature Communications how and why the copper-containing bilirubin oxidase (BOD) is an exceptional biocatalyst for the O2 reduction reaction (ORR). A longstanding goal of our research group is the establishment of new frontiers in in-situ techniques for the …
Grand challenges such as the fabrication of sensing devices for early diagnosis of cancer and detection of food/water contamination can only be addressed with concerted efforts in multidisciplinary research. Selected problems within the above challenges will be tackled in this Project by a multiinstitutional team of physicists, chemists, engineers, medical doctors and computer scientists,…
(Only some records are available in English at this moment)
Enzymatic catalysis of small molecules is a field of growing scientific and technological interest, with broad applications ranging from biotechnology to sustainable energy production. This project aims to explore the use of stable bioelectrodes in conjunction with in-situ techniques and bioelectrochemistry as an innovative approach to investigate these catalytic reactions in detail. Stab…
The use of enzymes to reduce CO2 and N2 for the bioelectrosynthesis of value-added products is a promising alternative to replace high-cost synthetic catalysts. For this purpose, interesting results have been obtained with the use of EcFDH-H and Mo-Fe nitrogenase enzymes immobilized on electrode surfaces. However, the bioelectrocatalytic and charge transfer mechanisms of these enzymes hav…
Some subjects which have not yet been studied or not clarified in the bioelectrochemistry field have an immediate impact on the development and use of energy bioconversion and fuel bioelectrosynthesis technologies. They include: halide inhibition of the multi-copper oxidases enzymatic activity towards the molecular oxygen reduction reaction and the mechanism of the reverse reaction (H2O o…
(Only some records are available in English at this moment)
The production of value-added products from enzymes or redox proteins found in nature is limited. This limitation can be overcome in the laboratory by modifying native enzymes, or by obtaining artificial apo-reconstituted proteins. In this project, we intend to contribute to frontier research in the area of metalloprotein bioengineering and to obtain new apo-reconstituted structures. Thus…
Saccharomyces cerevisiae is a facultative anaerobic fungus capable of performing extracellular electron transfer (EET) to solid surfaces, as electrodes, and, therefore, it has been used as a biocatalyst in microbiological fuel cells. Despite recent studies about the EET mechanism of this microorganism, none addresses the individual contributions of each cell to the process. Hence, this pr…
The preparation of biomolecule-nanostructure bioconjugates is a crucial step in the development of lateral flow immunoassays. Besides the high cost of reagents and biomolecules (e.g., proteins and monoclonal antibodies), the conjugation process between them and the metallic nanoparticles (MNPs) involves several experimental steps that require a lot of time, as in the case of the passive a…
(Only some records are available in English at this moment)
This research project aims the development and integration of nanostructured electrochemical devices for application in microchips, including organic batteries, biofuel cells and on-chip biosensors. In 2018, we began a scientific collaboration with Harvard University, where miniaturized batteries were developed for application in the new generation of microelectronics. These microbatterie…
Wearable batteries are anticipated to revolutionize the field of personalized medicine and reduce healthcare costs by enabling the widespread adoption of wearable sensors. However, the current lack of a suitable power source poses a significant hurdle to the advancement of wearable sensor technology. To address this challenge, our group in Brazil has proposed the utilization of bioinspire…
The development of biocatalysts for the bioelectrosynthesis of value-added compounds such as formate and ammonia has attracted great attention in the field of bioelectrochemistry. In addition to being highly efficient at room temperature and atmospheric pressure, biocatalysts are environmentally sustainable. The microbial surface display system can overcome some limitations of biocatalyst…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 13 / 11 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 25 / 24 | Completed scholarships in Brazil |
| 8 / 8 | Completed scholarships abroad |
| 53 / 50 | All research grants and scholarships |
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