CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Medicina from Faculdade de Medicina de São José do Rio Preto (1994) and doctorate at Endocrinologia e Metabologia from Faculdade de Medicina da Universidade de São Paulo (2003). Has experience in Medicine, focusing on Endocrinology, acting on the following subjects: biologia molecular, hipopituitarismo, expressão prop1, distúrbio do crescimento and craniofaringioma. (Source: Lattes Curriculum)
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Differences of Sex Development (DSD) represent a set of congenital diseases in which the development of chromosomal, gonadal, or anatomical sex is atypical. Current knowledge allows molecular diagnosis in only about 50% of patients. New mechanisms of gene regulation are emerging in novel causes of DSD and explaining different phenotypes caused by the same gene mutation. The identification…
Hypopituitarism is the deficiency of 1 or more hormones produced by the pituitary gland and, in most congenital cases, is associated with short stature due to GH deficiency (GHD) in childhood, which can evolve with other hormonal deficiencies during development and linear growth. Molecular investigation of genes involved in pituitary embryogenesis in the past 2 decades led to the diagnosi…
The development of molecular biology techniques to evaluate initial candidate gene by Sanger sequencing technique and then by analysis of the translated from all exons of the human genome region (exoma) for sequencing on a large scale (SELE) led to increasing molecular diagnostic research in genetic diseases. The Sanger sequencing allowed to determine the molecular etiology in about 10% o…
The maintenance of tissue in the adult organism requires a constant supply of new cells to replace cells lost to stress, injury or natural death. The cell replacement is possible through the activity attributed to tissue-specific stem cells. The anterior pituitary is an important regulatory role in the metabolism of the adult organism by regulating the hormone production. The cellular com…
(Only some records are available in English at this moment)
The pituitary gland is the master gland of the human body, responsible for theproduction and/or secretion of the following hormones: adrenocorticotropic (ACTH),thyroid-stimulating (TSH), growth (GH), follicle-stimulating (FSH), luteinizing (LH),prolactin (PRL), oxytocin, and antidiuretic hormone (ADH). Congenital hypopituitarismis a condition characterized by a deficiency in the productio…
The nuclear receptor TLX (Nr2e1) is a critical transcription factor for neural development and adult neurogenesis through its actions in regulating neural stem cell proliferation, self-renewal, and differentiation. However, the role of the Nr2e1 gene in pituitary development has not yet been characterized. This project aims to investigate a possible role of the Nr2e1 gene in the terminal …
The pituitary is the main endocrine organ in humans and its anterior part (adenohypophysis) is responsible for production and secretion of seven hormones that regulate growth, fertility and stress. The embryonic origin of the adenohypophysis is in the cranial placodes, in some animal models, the adenohypophyseal placode receives cells from the endoderm and the neuroectoderm when migrating…
Congenital hypopituitarism (CH) leads to a hormonal deficiency that causes a clinical picture marked mainly by short stature and delayed growth velocity. Around 85% of patients with CH remain with the genetic etiology of this hormonal deficiency unknown. In the Endocrinology department at HCFMUSP, only 12% of patients with Congenital Hypopituitarism have a molecular diagnosis. The develop…
The pituitary is a vital gland that produces and secretes hormones related to growth, fertility, lactation, and stress response. Deficiency of one or more pituitary hormones is known as Hypopituitarism, the congenital forms of this condition are mainly caused by inactivating mutations in the PROP1 gene, affecting about 52% of familial cases with topical neurohypophysis in the HCFMUSP coho…
Congenital hypopituitarism is a multiple hormonal deficiency due to mutations in transcription factors involved in pituitary embryogenesis. In humans, mutations in PROP1 gene are the most common cause of congenital hypopituitarism, that manifests by deficits of growth hormone (GH), thyroid-stimulating hormone (TSH), prolactin (PRL), gonadotropins (FSH and LH), and a variable and progressi…
(Only some records are available in English at this moment)
The pituitary is a vital gland that produces and secretes hormones related to growth, fertility, lactation, and stress response. Deficiency of one or more pituitary hormones is known as hypopituitarism, the congenital forms of this condition are mainly caused by inactivating mutations in the PROP1 gene, affecting about 52% of familial cases with topical neurohypophysis in the HCFMUSP coho…
This project aims to test the hypothesis that Prop1 regulates Nr2e1 expression that could be responsible for pituitary proliferation and differentiation. Nr2e1 is an orphan nuclear hormone receptor that is essential for neural stem cell maintenance and neogenesis, but none is known in pituitary. Ames dwarf mice harboring spontaneous mutation in Prop1 gene have congenital hypopitutiarism w…
| 1 / 1 | Ongoing grants |
| 6 / 4 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 9 / 8 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 21 / 18 | All research grants and scholarships |
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