CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas Modalidade Médica from Faculdade de Filosofia Ciências e Letras barão de Mauá (1988), master's at Paediatrics from Universidade Federal de São Paulo (1999) and ph.d. at Biologia de relação parasito-hospedeiro from Universidade de São Paulo (2004). Has experience in Parasitology, focusing on Parasite Protozoology, acting on the following subjects: t. cruzi, citocinas, imunologia aplicada, parasitemia and parasitologia. (Source: Lattes Curriculum)
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Parasitic protozoa of Trypanosoma and Leishmania species, respectively agents of Chagas disease and leishmaniasis, control their gene expression mainly through post-translational mechanisms. This is due to the selection of mRNAs that will be translated in each environment in which the parasites are located. During the passage from one host to another, changes occur in the availability of …
Infective forms of Trypanosoma cruzi, the causative agent of Chagas disease release vesicles enriched with glycoproteins that when injected into mice modulate parasite infection. The vesicles released by trypomastigotes of Y strain increases parasitism and inflammation of the heart tissue via the action of TNF-±, IL-12 and NO. Nogueira et al (2015) showed that vesicles isolated from YuYu,…
Trypomastigote forms of Trypanosoma cruzi, the causative agent of Chagas Disease, shed extracellular vesicles (EVs) enriched with glycoproteins of the gp85/trans-sialidase (TS) superfamily and other alpha-galactosyl (alpha-Gal)-containing glycoconjugates, such as mucins. Here, purified vesicles from T. cruzi strains (Y, Colombiana, CL-14 and YuYu) were quantified according to size, intens…
(Only some records are available in English at this moment)
Chagas disease (CD) is a neglected tropical disease caused by the protozoan Trypanosoma cruzi, that has been identified in Latin and Central America. Although ongoing efforts to treat the disease, individuals can develop chronic forms that seriously compromise their hearts and digestive systems. Chronic Chagas cardiomyopathy (CCC) is one of the most serious consequences, affecting approxi…
Trypanosoma cruzi is capable to infect a variety of host cells. Recently, several studies have demonstrated the relationship of the released plasma membrane vesicles with various diseases such as cancer, thrombosis and parasitic infections. Results from our group showed that vesicles of T. cruzi released in the culture medium containing glycoconjugates are rich in ±-galactose epitopes, in…
| 1 / 1 | Ongoing grants |
| 8 / 6 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 5 / 2 | Completed scholarships in Brazil |
| 15 / 10 | All research grants and scholarships |
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