CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Associate professor at the Universidade de São Paulo. Main field of research: Molecular Genetics of Microorganisms.Current main subjects of research: experimental bacterial evolution, bacterial adaptation to environmental stresses and regulation of gene expression. Use of bacteria for the bioremediation of sewage. (Source: Lattes Curriculum)
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Mutations are defined as heritable changes in the DNA sequence of a genome. The frequency with which mutants appear in a population varies according to several factors, among them, the organism species, the locus of the mutation, gain or loss of fitness, presence/expression of DNA repair genes and other elements. In Escherichia coli, PHO-constitutive mutations occur mainly in the pst oper…
Mutations are rare and random events that occur in the genome of an organism. Since the classical Luria-Delbrück demonstration, it is known that mutations in bacteria occur at random, i.e., they are not targeted to specific loci in response to specific selective pressures. However, there is a second category of bacterial mutations that appear to be targeted, the so-called adaptive mutatio…
Escherichia coli genome encodes seven different sigma factors. The primary sigma factor, Ã70 , is responsible for the transcription of most genes, in particular those associated with bacterial growth. RpoS (ÃS ) is the second in importance, being involved in the transcription of genes associated with the general stress response. Despite its relevance, the rpoS gene is very polymorphic and…
(Only some records are available in English at this moment)
We live in an era of science and technology. While science deals with the material world, it also requires a high degree of abstraction, due in part to the heavy use of mathematics, but also due to the need to formulate hypotheses, design experiments, and assess their conclusions based on abstract concepts. The purpose of the micromath program is to strengthen mathematical concepts throug…
One of the main reasons that bacteriophages are not widely used for the treatment of bacterial infections is their very narrow host ranges, meaning that they are able to infect only one or few phylogenetically closed species and even in a single species, they can infect only a fraction of the known strains. This specificity may be sometimes overcome by introducing or selecting mutations i…
The most fundamental feature of any microorganisms is its ability to grow. Unsurprisingly, growth rate is influenced by many different inputs, the most basic one being the concentration of the alarmone (p)ppGpp. It is reasonably well established that this small nucleotide controls growth rate mainly through an effective inhibition of stable RNA (rRNA and tRNA) synthesis. The level of (p)p…
(Only some records are available in English at this moment)
One of the main challenges of public outreach and efficient science communication is theability to convey abstract and complex scientific thoughts and results to the generalpublic in a clear and understandable language. This is the main task of sciencejournalism.We are thus asking for two 6-month JC-2 scholarships effective from the beginning of thesecond semestre of the CEPID's first yea…
A protocol for conducting experiments in schools is being developed based on the results of laboratory tests. Through basic microbiology, we can gain a deeper understanding of mathematical concepts.
The PHO regulon is a set of genes and operons scattered along the bacterial DNA and co-regulated by a single environmental factor: the low extracellular concentration of orthophosphate (Pi). This mechanism gives bacteria an evolutionary advantage in adapting to environments poor in phosphorus, an essential nutrient for their growth. The regulation of PHO regulation is strictly dependent o…
(Only some records are available in English at this moment)
| 16 / 11 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 38 / 26 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 61 / 44 | All research grants and scholarships |
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