Fabio Bessa Lima
CV Lattes
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Medical Doctor School of Medicine of the University of São Paulo (1973) and Ph.D. in Physiology, University of São Paulo (1980). Post-doctoral fellow in University of California at San Diego, School of Medicine, Endocrinology Session, in the group of Professor Jerrold M. Olefsky, 1986-1988. Currently, full professor at Universidade de São Paulo (since 2008). Has experience in Endocrine Physiology, particularly on the following subjects: adipose tissue physiology, metabolic adaptations of the AT to exercise, AT and diabetes mellitus, AT developmente during puberty, pineal gland and AT interactions, hypercortisolism and AT, AT in insulin resistance, obesity and metabolism. (Source: Lattes Curriculum)
- EMU (Multi-User Equipment) granted to the process 16/25129-4. name of the equipment: liquid scintillator Tri-Carb 5110TR, AP.EMU
Abstract
The Cushing's syndrome encompasses a set of malaises characterized by an excessive and chronic (endogenous or iatrogenic) exposition to glucocorticoids that leads to a disruption of the circadian rhythm the hypothalamic-hypophyseal-adrenal axis. Clinically, in humans, the picture is manifested by a body fat redistribution with increase in the central (truncal) part of the body and reduc...
- Iatrogenic Chronic Hypercortisolism and its implications to the adipose tissue plasticity an analysis of the dynamics of adipose tissue distribution in an experimental model of Cushing's Syndrome, AP.TEM
Abstract
The Cushing's Syndrome encompasses a set of malaises characterized by an excessive and chronic (endogenous or iatrogenic) exposition to glucocorticoids that leads to a disruption of the circadian rhythm the hypothalamic-hypophyseal-adrenal axis. Clinically, in humans, the picture is manifested by a body fat redistribution with increase in the central (truncal) part of the body and reduc...
- Obesity week Annual Meeting 2017, AR.EXT
- Investigation of the molecular aspects of the lipogenesis/lipolysis and adipogenesis/apoptosis in middle-aged rats supplemented or not with melatonin, AP.R
Abstract
It is a current observation intensely supported by several scientific publications that a strong propensity to obesity develops with ageing. In parallel, there is a functional decline of the pineal gland. These two observations have instigated the research with the aim to identify possible associative aspects between them. Thus, we have developed studies that demonstrated that pinealect...
- Consequences of neonatal Diabetes Mellitus to pubertal adipose tissue development in male rats. 1. Effects on adipogenesis. 2. Effects of thiazolidinedione and melatonin treatment, AP.R
Abstract
Adipose tissue, nowadays considered an endocrine and metabolic organ, participates actively in the regulation of the energy metabolism and store, of feeding behavior and body weight. Deficiencies in its formation compromises the body development and quality of life as seen in lipodystrophic syndromes, leading to severe metabolic alterations like insulin resistance, diabetes mellitus and...
(Only some records are available in English at this moment)
- Alterations in adipogenesis and apoptosis in different adipose territories induced by the chronic iatrogenic hypercortisolism, BP.PD
Abstract
Cushing's syndrome is a disease characterized by excessive (endogenous or iatrogenic) exposure to glucocorticoids, resulting in corticotropic axis dysfunction. Within this metabolic syndrome there are classic components: body fat redistribution with increased central adiposity and limb reduction, insulin resistance, dyslipidemia, muscle atrophy, osteopenia, abdominal striae, exacerbated...
- Study of changes in endocrine capacities in different anatomical adipose tissues induced by chronic iatrogenic hypercortisolism, BP.IC
Abstract
For a long time, adipose tissue was seen only as a metabolic support, to which a merely passive functional role was attributed. However, in recent years, the discovery of the ability to secrete numerous biologically active compounds has caused this tissue to gain the status of an endocrine organ, and the compounds that are only produced and secreted by it, are called adipokines. Among t...
- Study of alterations in thermogenic capacity and regulation of browning / whitening in adipose territories of different anatomical locations induced by chronic iatrogenic hypercortisolism, BP.DR
Abstract
Cushing's syndrome is an endocrine disorder caused by chronic exposure to glucocorticoids. Its etiology is varied, but the most common cause is prolonged use of synthetic glucocorticoids - the iatrogenic hypercortisolism. One of the most important characteristics of this syndrome is the rupture of the circadian rhythm of glucocorticoid release and hormonal action, seriously disturbing t...
(Only some records are available in English at this moment)
- Characterization of the effects of supplementation of beta-hydroxybutyrate salts in plasma parameters, adipose tissue morphology and expression of adiponectin, BP.IC
Abstract
In recent years, studies have been published on the possible beneficial effects of physiological ketosis. Several diseases such as Epilepsy, Alzheimer's disease, Parkinson's disease and Metabolic Syndrome, have been shown treatable with ketogenic diets. However, little is known about the effects of ketone bodies alone on metabolic parameters influenced by ketogenic diets. Our project ha...
- Effect of beta-hydroxybutyrate in mitochondrial function of isolated white adipocytes, BP.DR
Abstract
Among the ketones bodies, Beta- hydroxybutyrate (B-OH) is larger in quantity during ketogenesis, as well as possibilities of effects. The B-OH can activate membrane receptors, inhibit enzymes which control histone acetylation, induce intense formation of acetyl-CoA and energy for cellular metabolism. Data support the idea that the B-OH is signaling metabolite which influence metabolism ...
- The influence of chronic aerobic training and physical detraining on adiposity in subcutaneous and retroperitoneal rat fat PAD: characterization of apoptosis and adipogenesis, BP.PD
Abstract
Obesity is considered a public health problem that affects all societies worldwide. Excessive white adipose tissue (WAT) is positively correlated with increased morbidity and mortality, mainly by increasing risk factors for cardiovascular and metabolic diseases. The physical exercise, a lifestyle habit, is both an important non-pharmacological tool to fight obesity and an interesting mo...
(Only some records are available in English at this moment)
- P38alpha MAPK role in the beta-adrenergic pathways, browning and whitening of adipose tissue in an experimental model of chronic iatrogenic hypercortisolism, BE.EP.DR
Abstract
Obesity/adipose redistribution is one of the characteristics of hypercortisolism/Cushing's syndrome, reproduced in our experimental model of hypercortisolism in rats. Our goal is to understand how glucocorticoid excess affect browning and whitening process in various fat deposits and whether these effects correlate with the fat redistribution in this pathological state. Partial results ...
- The influence of cardiac natriuretic peptides on the browning of adipose tissue, BE.EP.PD
Abstract
Brown adipose tissue (BAT) evolved as a molecular mechanism for generating heat from stored metabolic products, i. e. carbohydrates and lipids. Brown adipocytes are highly enriched in mitochondria and express a unique protein called uncoupling protein-1 (UCP1) The brown fat humans is significantly correlated with reduced percent body fat, lower incidence of Type II diabetes, and greater...
- Effects of adipose triglyceride lipase (ATGL) in function and phenotype of adipose tissue, lipid homeostasis and function of other tissues, BE.EP.DR
Abstract
White adipose tissue is the major reservoir of energy in the body storing the excess of energy from diet as triacylglycerol. The amount of triacylgycerol stored in the adipose tissue depends on the balance between triacylglycerol synthesis and degradation denominated as lipogenesis and lipolysis, respectively. Lipolysis refers to sequential hydrolysis of triacylglycerol to diacylglycero...
| 2 / 2 | Ongoing research grants |
| 21 / 14 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 28 / 8 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 58 / 31 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 13 |
| Citations | 210 |
| Cit./Article | 16.2 |
| Data from Web of Science | |
NUNES, PATRICIA PEREIRA; ANDREOTTI, SANDRA; SILVA, FLAVIANE DE FATIMA; LAURATO SERTIE, ROGERIO ANTONIO; CAMINHOTTO, RENNAN DE OLIVEIRA; MEDEIROS KOMINO, AYUMI CRISTINA; REIS, GABRIELA BOLTES; LIMA, FABIO BESSA. Chronic low-dose glucocorticoid treatment increases subcutaneous abdominal fat, but not visceral fat, of male Wistar rats. Life Sciences, v. 190, p. 29-35, DEC 1 2017. Web of Science Citations: 4. (13/24557-4)
CAMINHOTTO, RENNAN DE OLIVEIRA; TAVARES DA FONSECA, FELIPE LUCAS; DE CASTRO, NATALIE CAROLINA; ARANTES, JOAO PEDRO; LAURATO SERTIE, ROGERIO ANTONIO. Atkins diet program rapidly decreases atherogenic index of plasma in trained adapted overweight men. Arquivos Brasileiros de Endocrinologia e Metabologia, v. 59, n. 6, p. 568-571, DEC 2015. Web of Science Citations: 7. (14/10705-4, 13/13601-2)
SERTIE, ROGERIO A. L.; CURI, RUI; OLIVEIRA, ARICLECIO C.; ANDREOTTI, SANDRA; CAMINHOTTO, RENNAN O.; DE LIMA, THAIS MARTINS; PROENCA, ANDRE R. G.; REIS, GABRIELA B.; LIMA, FABIO B.. The mechanisms involved in the increased adiposity induced by interruption of regular physical exercise practice. Life Sciences, v. 222, p. 103-111, APR 1 2019. Web of Science Citations: 1. (13/13601-2)
RENNAN DE OLIVEIRA CAMINHOTTO; FABIO BESSA LIMA. Low carbohydrate high fat diets: when models do not match reality. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 60, n. 4, p. -, Ago. 2016. (14/10705-4)
CHIMIN, P.; FARIAS, T. DA S. M.; TORRES-LEAL, F. L.; BOLSONI-LOPES, A.; CAMPANA, A. B.; ANDREOTTI, S.; LIMA, F. B.. Chronic glucocorticoid treatment enhances lipogenic activity in visceral adipocytes of male Wistar rats. ACTA PHYSIOLOGICA, v. 211, n. 2, p. 409-420, JUN 2014. Web of Science Citations: 23.
DE OLIVEIRA, ARICLECIO CUNHA; ANDREOTTI, SANDRA; LAURATO SERTIE, ROGERIO ANTONIO; CAMPANA, AMANDA BARON; GOMES DE PROENCA, ANDRE RICARDO; VASCONCELOS, RENATA PRADO; DE OLIVEIRA, KECIANY ALVES; COELHO-DE-SOUZA, ANDRELINA NORONHA; DONATO-JUNIOR, JOSE; LIMA, FABIO BESSA. Combined treatment with melatonin and insulin improves glycemic control, white adipose tissue metabolism and reproductive axis of diabetic male rats. Life Sciences, v. 199, p. 158-166, APR 15 2018. Web of Science Citations: 6. (10/00246-1)
FONSECA-ALANIZ‚ M.H.; BRITO‚ L.C.; BORGES-SILVA‚ C.N.; TAKADA‚ J.; ANDREOTTI‚ S.; LIMA‚ F.B.. High Dietary Sodium Intake Increases White Adipose Tissue Mass and Plasma Leptin in Rats&ast. OBESITY, v. 15, n. 9, p. 2200-2208, 2007.
MENDES DE FARIAS, TALITA DA SILVA; DE OLIVEIRA, ARICLECIO CUNHA; ANDREOTTI, SANDRA; DO AMARAL, FERNANDA GASPAR; CHIMIN, PATRICIA; ALVES DE PROENCA, ANDRE RICARDO; LEONARDO TORRES LEAL, FRANCISCO; LAURATO SERTIE, ROGERIO ANTONIO; CAMPANA, AMANDA BARON; LOPES, ANDRESSA BOLSONI; et al. Pinealectomy interferes with the circadian clock genes expression in white adipose tissue. Journal of Pineal Research, v. 58, n. 3, p. 251-261, APR 2015. Web of Science Citations: 26. (10/20719-1)
BOLSONI-LOPES, ANDRESSA; FESTUCCIA, WILLIAM T.; FARIAS, TALITA S. M.; CHIMIN, PATRICIA; TORRES-LEAL, FRANCISCO L.; DEROGIS, PRISCILLA B. M.; DE ANDRADE, PAULA B.; MIYAMOTO, SAYURI; LIMA, FABIO B.; CURI, RUI; et al. Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipase content in a PPAR alpha-dependent manner. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 305, n. 9, p. E1093-E1102, NOV 2013. Web of Science Citations: 25. (11/51627-8, 09/15354-7, 10/10909-8)
CARDOSO ALONSO-VALE, MARIA ISABEL; ANDREOTTI, SANDRA; MUKAI, PAULA YURI; BORGES-SILVA, CRISTINA DAS NEVES; PERES, SIDNEY BARNABE; CIPOLLA-NETO, JOSE; LIMA, FABIO BESSA. Melatonin and the circadian entrainment of metabolic and hormonal activities in primary isolated adipocytes. Journal of Pineal Research, v. 45, n. 4, p. 422-429, NOV 2008. Web of Science Citations: 60. (04/06767-2)
LAURATO SERTIE, ROGERIO ANTONIO; CAMINHOTTO, RENNAN DE OLIVEIRA; ANDREOTTI, SANDRA; CAMPANA, AMANDA BARON; GOMES DE PROENCA, ANDRE RICARDO; DE CASTRO, NATALIE CAROLINA; LIMA, FABIO BESSA. Metabolic adaptations in the adipose tissue that underlie the body fat mass gain in middle-aged rats. AGE, v. 37, n. 5, OCT 2015. Web of Science Citations: 1. (14/15210-3)
ALONSO-VALE, M. I. C.; BORGES-SILVA, C. N.; ANHÊ, G. F.; ANDREOTTI, S.; MACHADO, M. A.; CIPOLLA-NETO, J.; LIMA, F. B.. Light/dark cycle-dependent metabolic changes in adipose tissue of pinealectomized rats. Hormone and Metabolic Research, v. 36, n. 7, p. 474-479, July 2004.
BORGES-SILVA, CRISTINA N.; ALONSO-VALE, M. I. C.; FRANZÓI-DE-MORAES, SOLANGE M.; TAKADA, JULIE; PERES, SIDNEY B.; ANDREOTTI, SANDRA; SKORUPA, ANA L.; CIPOLLA-NETO, JOSÉ; PITHON-CURI, TÂNIA C.; LIMA, FÁBIO B.. Pinealectomy impairs adipose tissue adaptability to exercise in rats. Journal of Pineal Research, v. 38, n. 04, p. 278-283, May 2005.
BORGES-SILVA, CRISTINA DAS NEVES; FONSECA-ALANIZ, MIRIAM H.; ALONSO-VALE, MARIA I. C.; TAKADA, JULIE; ANDREOTTI, SANDRA; PERES, SIDNEY B.; CIPOLLA-NETO, JOSÉ; PITHON-CURI, TÂNIA C.; LIMA, FABIO B.. Reduced lipolysis and increased lipogenesis in adipose tissue from pinealectomized rats adapted to training. Journal of Pineal Research, v. 39, n. 2, p. 178-184, Sept. 2005.
ALONSO-VALE, MARIA ISABEL CARDOSO; ANHÊ, GABRIEL FORATO; BORGES-SILVA, CRISTINA DAS NEVES; ANDREOTTI, SANDRA; PERES, SIDNEY BARNABÉ; CIPOLLA-NETO, JOSÉ; LIMA, FABIO BESSA. Pinealectomy alters adipose tissue adaptability to fasting in rats. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 53, n. 04, p. 500-506, Apr. 2004.
BORGES-SILVA, CRISTINA DAS NEVES; TAKADA, JULIE; ALONSO-VALE, MARIA ISABEL CARDOSO; PERES, SIDNEY B.; FONSECA-ALANIZ, MIRIAM H.; ANDREOTTI, SANDRA; CIPOLLA-NETO, JOSE; PITHON-CURI, TANIA C.; LIMA, FABIO BESSA. Pinealectomy reduces hepatic and muscular glycogen content and attenuates aerobic power adaptability in trained rats. Journal of Pineal Research, v. 43, n. 1, p. 96-103, Aug. 2007. (04/06767-2)
OLIVEIRA, ARICLECIO C.; ANDREOTTI, SANDRA; CHIMIN, PATRICIA; SERTIE, ROGERIO A. L.; FARIAS, TALITA DA S. M.; TORRES-LEAL, FRANCISCO L.; DE PROENCA, ANDRE R. G.; CAMPANA, AMANDA B.; D'AVILA, LIOHANNA S. P.; OLIVEIRA, KECIANY A.; et al. Neonatal streptozotocin-induced diabetes in mothers promotes metabolic programming of adipose tissue in male rat offspring. Life Sciences, v. 136, p. 151-156, SEP 1 2015. Web of Science Citations: 1. (10/00246-1)
CARDOSO ALONSO-VALE, MARIA ISABEL; PERES, SIDNEY BARNABE; VERNOCHET, CECILE; FARMER, STEPHEN R.; LIMA, FABIO BESSA. Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBP beta transcriptional activity. Journal of Pineal Research, v. 47, n. 3, p. 221-227, OCT 2009. Web of Science Citations: 50. (04/06767-2)
CAMINHOTTO, RENNAN DE OLIVEIRA; MEDEIROS KOMINO, AYUMI CRISTINA; SILVA, FLAVIANE DE FATIMA; ANDREOTTI, SANDRA; LAURATO SERTIE, ROGERIO ANTONIO; REIS, GABRIELA BOLTES; LIMA, FABIO BESSA. Oral beta-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats. NUTRITION & METABOLISM, v. 14, APR 24 2017. Web of Science Citations: 6. (14/10705-4, 16/10218-1)
CAMINHOTTO, RENNAN DE OLIVEIRA; ANDREOTTI, SANDRA; MEDEIROS KOMINO, AYUMI CRISTINA; SILVA, FLAVIANE DE FATIMA; SERTIE, ROGERIO ANTONIO LAURATO; CHRISTOFFOLETE, MARCELO AUGUSTO; REIS, GABRIELA BOLTES; LIMA, FABIO BESSA. Physiological concentrations of beta-hydroxybutyrate do not promote adipocyte browning. Life Sciences, v. 232, SEP 1 2019. Web of Science Citations: 0. (14/10705-4)
(References retrieved automatically from State of São Paulo Research Institutions)
PERES, Sidney Barnabé. O treinamento físico e o destreinamento aumentam a responsividade à insulina no tecido adiposo branco. v,75 f. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (99/09689-2)
CAMPANA, Amanda Baron. A intolerância à glicose que se instala precocemente em ratos retarda o desenvolvimento puberal e desregula o metabolismo lipídico e glicídico.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (05/56666-0)
CARVALHO, Talita da Silva Mendes de Farias. Caracterização do perfil diário da lipólise e lipogênese no tecido adiposo de ratos adultos e a influência da pinealectomia.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (08/56387-2)
CARVALHO, Talita da Silva Mendes de Farias. Os efeitos da pinealectomia sobre a expressão de clock genes e lipogênese no tecido adiposo branco epididimal de ratos adultos Wistar.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (10/20719-1)
CAMINHOTTO, Rennan de Oliveira. Bloqueadores farmacológicos do sistema renina-angiotensina e a regulação do metabolismo de adipócitos isolados.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (12/02054-8)
CAMINHOTTO, Rennan de Oliveira. Concentrações fisiológicas de corpos cetônicos não induzem browning em adipócitos/tecido adiposo: estudos in vitro e in vivo.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (14/10705-4)
PROENÇA, André Ricardo Gomes de. Exercício físico e melatonina promovem conjuntamente redução da adiposidade em ratos, embora estes se tornem hipogonádicos.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (09/54732-7)
TRALDI, Patricia Pereira Nunes. A exposição crônica, contínua e invariável do organismo ao cortisol aumenta o tecido adiposo subcutâneo abdominal.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (13/24557-4)
CHIMIN, Patricia. Características metabólicas diferenciais de distintos territórios adiposos em ratos submetidos a tratamento prolongado, contínuo e excessivo com glicocorticoides: um modelo de síndrome de Cushing iatrogênica.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (09/54058-4)
CASTRO, Natalie Carolina de. O volume celular do adipócito contribui para a heterogeneidade funcional do tecido adiposo branco. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (08/51588-0)
LEAL, Francisco Leonardo Torres. Leucina intensifica o ganho de adiposidade e as respostas metabólicas do tecido adiposo em ratos previamente obesos por dieta hiperlipídica e a gordura subcutânea é uma das mais afetadas.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (10/50093-7)
LOPES, Andressa Bolsoni. Efeitos do ácido palmitoleico na captação e metabolismo de glicose e triacilglicerol em adipócitos brancos.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (09/53964-1)
PROENÇA, André Ricardo Gomes de. Exercício físico e melatonina promovem conjuntamente redução da adiposidade em ratos, embora estes se tornem hipogonádicos.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (09/54732-7)
TRALDI, Patricia Pereira Nunes. A exposição crônica, contínua e invariável do organismo ao cortisol aumenta o tecido adiposo subcutâneo abdominal.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (13/24557-4)