CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at MEDICINA from Universidade Federal de São Paulo (1982), master's at Infectious and Parasitic Illnesses from Universidade Federal de São Paulo (1988) and doctorate at Infectious and Parasitic Illnesses from Universidade Federal de São Paulo (1992). Has experience in Immunology, focusing on Celular Imunology, acting on the following subjects: necrose tumoral, citocinas, linfócitos t, terapeutica and cytokines. (Source: Lattes Curriculum)
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Sepsis is defined as severe, potentially fatal organ dysfunction caused by an inadequate or dysregulated host response to infection. It is extremely relevant in public health due to its high morbidity and mortality, being recognized as a global health priority by the World Health Organization, with around 48.9 million cases and 11 million related deaths estimated in 2017.The host response…
To represent FAPESP in the Global Alliance for Chronic Diseases (GACD). GACD is a collaboration of global health and medical research funding bodies. The Alliance initiates, facilitates and supports joint research activities on chronic, non-communicable diseases (NCDs) in low- and middle-income countries (LMICs) and in vulnerable and indigenous communities in high-income countries (HIC) t…
We are starting the activities of units (wards and ICU) for the care of patients with COVID-19 at Hospital São Paulo, therefore, with the opportunity to prospectively monitor patients with moderate-to-moderate / severe illness. These patients will be with clinical manifestations between those who will be discharged to the home (mild cases) and those who should be directly admitted to Inte…
In Brazil, about one-third of the intensive care beds are occupied by septic patients, with a mortality rate of 55.7% compared to the 26% worldwide averages reported recently. In this project we intend to integrate basic and clinical research in Sepsis, ranging from the pathogenesis and development of intervention strategies to epidemiological studies that allow us to know the reality of …
(Only some records are available in English at this moment)
AbstractSepsis is a public health problem that presents high morbidity and mortality, being one of the main causes of death in intensive care units. This condition, defined as a dysregulated host response to infection, has neutrophils as one of the first lines of defense against pathogens. Neutrophils are a priority in the lesion focus and even in adverse metabolic conditions they are cap…
Low Density Neutrophils (LDNs) and Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are terms designating the same type of immune cells which on the one hand seem to be associated with reduced antigen presentation capacity and inhibition of T lymphocyte activation and proliferation, but on the other hand appear to have increased functions such as production of neutrophil ext…
Low Density Neutrophils (LDNs) and Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are terms designating the same type of immune cells which on the one hand seem to be associated with reduced antigen presentation capacity and inhibition of T lymphocyte activation and proliferation, but on the other hand appear to have increased functions such as production of neutrophil ext…
(Only some records are available in English at this moment)
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. The host response during sepsis shows signs of concurrent hyperinflammation and immunosuppression. A recent study identified a CD14+ monocyte phenotype in the blood of sepsis patients named MS1, characterized by high expression of RETN, ALOX5AP, and IL1R2, and the abundance of…
Poly(ADP-polymerase)1 (PARP1, the major isoform of a family of poly(ADP-ribosyl)ating enzymes), a constitutive enzyme, is a key regulator of DNA repair, cell death and gene expression. Activation of PARP in response to reactive oxidants promotes cell death and pro-inflammatory signalling. Pathophysiological PARP over-activation and the beneficial effects of PARP inhibitors have been demon…
Respiratory tract infections are a major cause of sepsis. Several defense mechanisms are required to protect the airways from harmful events. Those include epithelial cells, as the first barrier, and innate immune cells. Energy metabolism has an important role in the regulation of cellular function, for instance, activated cells switch their metabolism from oxidative phosphorylation to ae…
| 2 / 1 | Ongoing grants |
| 17 / 10 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 17 / 10 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 40 / 25 | All research grants and scholarships |
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