CV Lattes
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Universidade de São Paulo (USP). Escola de Engenharia de Lorena (EEL) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Dr. André Lopes earned a B.S. (2004) in Biology at São Paulo State University (UNESP, Brazil), and an M.S. (2006) and Ph.D. (2010) in Biochemical and Pharmaceutical Technology at the University of São Paulo (USP, Brazil). His Ph.D. thesis focused on upstream and downstream processes for the application of bioproducts related to human health. More specifically, through biotechnological processes for obtaining biomolecules via genetically modified or unmodified microbial sources and their extraction/purification by high and low-resolution processes. During the last years, his research is focused on nanobiotechnology, particularly regarding drug delivery systems with the incorporation of therapeutics (e.g., biopharmaceuticals, biomolecules, and drugs) in nanostructures, such as polymeric micelles, polymersomes, polymeric scaffolds, among others. Dr. Lopes was a Postdoctoral Fellow at the Department of Biochemical and Pharmaceutical Technology at the University of São Paulo (2012 and 2014), and at the Department of Bioengineering at the University of California - Los Angeles (UCLA, USA) under the supervision of Prof. Daniel T. Kamei (2016). He was also a Postdoctoral Fellow at the Department of Bioprocess and Biotechnology at the São Paulo State University (2018).Currently, Dr. Lopes is a Professor at the Lorena School of Engineering - University of São Paulo (EEL/USP, Brazil). His research project is related to the co-encapsulation of antineoplastic drugs in polymersomes for cancer therapy. Links:ORCID: https://orcid.org/0000-0002-3570-2470;Publons: https://publons.com/researcher/1163683/andre-m-lopes/;Google Scholar: https://scholar.google.com.br/citations?user=WTirhR4AAAAJ (Source: Lattes Curriculum)
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Cancer ranks as one of the primary causes of death globally, with 10 million fatalities recorded in 2020, second only to heart disease. In oncology, chemotherapy remains a cornerstone approach, involving the administration of drugs and biopharmaceuticals (biomolecules) directly into the patient's bloodstream. Nonetheless, the purification and encapsulation of these biomolecules into nanos…
In this research project, we propose to investigate a novel co-therapy approach using smart drug delivery systems in melanoma therapy. This approach will employ multi-drug delivery from nanostructures of polymer vesicle-type, otherwise known as polymersomes (Ps), which represents an innovative alternative for the treatment of cancer. Specifically, vemurafenib, a specific inhibitor of muta…
Curcumin (CCM) is a biomolecule with significant therapeutic potential, exhibiting anti-inflammatory, antimicrobial, antioxidant, and antitumor properties. However, its low water solubility and rapid degradation limit its bioavailability and clinical efficacy. To overcome these challenges, nanobiotechnological encapsulation strategies are essential for enhancing its physicochemical and th…
TIMP proteins are a family of endogenous inhibitors of matrix metalloproteinases (MMPs) and its unbalance in the organism is associated with many pathological conditions, suggesting TIMPs as a potential therapeutic agent, in special for cancer treatment. In a context where biomolecules with therapeutic properties have gained significant visibility, one barrier to its application is the ch…
Curcumin (CCM) is a biomolecule with immense potential in the clinical-therapeutic realm due to its notable properties: anti-inflammatory, antimicrobial, antitumor, and antioxidant. Nevertheless, it exhibits poor solubility in aqueous environments, resulting in limited bioavailability upon administration into the bloodstream. To harness its therapeutic attributes, a nanobiotechnological a…
The release of drugs from nanostructures like polymersomes (Ps), represents a promising alternative for cancer treatment. Aiming in major effectiveness of suppression of malignant tumors the application of combining therapy (co-therapy) has been largely applied and studied in late years. In this case, recent clinical studies had shown that treatments combining free drugs can increase the …
The combinatorial approach of drugs (co-therapy) has been widely used in cancer therapy. Recent clinical studies have shown that treatments that combine free drugs may increase tumor regression rates compared to individual administration. However, a relevant aspect to be considered is related to the dose-dependent toxicity of the co-therapeutic administration of drugs. Moreover, this obst…
(Only some records are available in English at this moment)
Presently it has been increasingly developed many applications biomaterials biotechnology, since the biomaterials used for implants and implants with catheters urinary and venous. These biomaterials are often colonized by pathogens can cause serious infections and rejection. Often biofilm formation by Candida spp., which enhances the deterioration of these biomaterials. Therefore, it is e…
| 1 / 1 | Ongoing grants |
| 2 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 9 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 15 / 12 | All research grants and scholarships |
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