CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Dr. Calado graduated in Medicine from Universidade de São Paulo in 1997 and received his PhD in Medical Sciences [Ribeirão Preto] from Universidade de São Paulo in 2003. Dr. Calado is Associate Professor of Medicine at the University of São Paulo at Ribeirão Preto Medical School and his research expertise is in Medicine, focusing on Hematology, acting on the following subjects: aplastic anemia, bone marrow failure, telomere disease and biology, telomerase, and chromosomal instability. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Desgaste rápido |
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
The Nucleus of Cellular Therapy - NuTeC will be founded on the union of the Regional Blood Center of Ribeirão Preto (Hemocentro RP) and Butantan. Hemocentro RP expertise in cellular therapy will be added to Butantan excellence in the development and production of health applied products to develop CAR T cell therapy. The activities to be conducted by NuTeC are aligned with the scope of th…
We propose a program of basic and clinical research to isolate, culture, and characterize embryonic ,somatic, and neoplastic stem cells in order to understand their biology and apply this knowledge to therapy, comprising four research lines: (1) pluripotent stem cells (SC) (embryonic SC and induced pluripotent SC); (2) somatic SC (hematopoietic SC, mesenchymal SC, endothelial SC, and canc…
The pandemia caused by the virus SARS-CoV-2 is spreading rapidly around the world, and now reached Brazil. However, its magnitude and consequences are still unknown in this country. In this study, the authors intend to evaluate the impact of convalescent plasma transfusion on patients with severe COVID-19. The clinical picture of this disease is heterogenous, with most patients with mild …
Telomeres are the repetitive nucleotide structures at the end of the linear chromosomes that, when critically short, engage cell senescence, apoptosis, or chromosome instability. In cells with high proliferative demand, telomeres are repaired by telomerase, a reverse transcriptase that adds hexanucleotides to the 3' end of the DNA leading strand. In humans, germline mutations in telomere-…
Telomeres are ribonuclear structures located at the ends of linear cromosomes that maintain genomic integrity. Germline mutations in genes involved in telomere repair and maintenance lead to excessive telomere shortening, ultimately resulting in cell senescence and/or apoptosis. In humans, telomere dysfunction manifests as disease compromising several organs, such as aplastic anemia (AA),…
The hematopoietic stem cell transplantation (HSCT), or allogeneic bone marrow transplantation (BMT), has been used as treatment to a number of malignant and non-malignant diseases. It consists in the usage of hematopoietic stem cells (HSCs) mobilized from peripheral blood, bone marrow or umbilical cord blood of donors related or not with the receptor they're transferred to. After their in…
Telomeres are repetitive sequences of hexanucleotides located at the ends of linear chromosomes that, when critically short, can trigger chromosomal instability, senescence, or apoptosis. Pathogenic variants in genes involved in telomere biology can lead to excessive telomere shortening and diseases most frequently affecting the bone marrow, but also the skin, lungs, liver and predisposin…
Telomeres are complex structures made up of repetitive nucleotide sequences that associate with proteins to form the ends of linear chromosomes. Telomeric extension decreases with each mitotic cycle and once the telomere length becomes too short, it induces cells to enter senescence or apoptosis. Some cell types, such as embryonic or adult stem cells, must maintain their proliferative cap…
Telomeres are repetitive structures of nucleotides and regulatory proteins located at the ends of linear chromosomes whose function is the maintenance of genomic integrity. Critically short telomeres induce disruption of cell proliferation, senescence or apoptosis. In cells with high proliferative demand, the telomeric length is maintained by the enzymatic complex of the telomerase, which…
Acquired aplastic anemia is a disease in which hematopoietic stem cell failure occurs, leading to pancytopenia associated with hypocellular bone marrow. The disease is caused by the destruction of hematopoietic precursors by a cytotoxic T cell mediated immune mechanism. Historically, the mortality of this disease has always been high, both due to acute complications of pancytopenia and co…
Hematopoietic stem cells may acquire mutations that confer a replicative advantage, leading to the expansion of the mutated cell, the so-called clonal hematopoiesis. Somatic mutations that give rise to clonal hematopoiesis are rare in the first four decades of life but increase in frequency with aging, affecting mainly three genes: DNMT3A, TET2 e ASXL1. These genes are also frequently mut…
(Only some records are available in English at this moment)
Telomeres are the repetitive nucleotide structures at the end of linear chromosomes that, when critically short, engage cell senescence, apoptosis, or chromosome instability. In cells with high proliferative demand, telomeres are repaired by telomerase, a reverse transcriptase that adds hexanucleotides to the 3' end of the DNA leading strand. In humans, germline mutations in telomere-biol…
Acquired aplastic anemia (AA) is a rare hematologic disorder defined by pancytopenia with bone marrow hypoplasia. In most patients with AA the destruction of hematopoiesis is due to an immune mechanism dominated by activated cytotoxic T cells that target the hematopoietic progenitors in bone marrow. Hematopoiesis may be restored with bone marrow transplant (BMT) from a matched-sibling don…
Telomeres are nucleotide specific sequences at the ends of eukaryotic linear chromosomes and are responsible for protecting chromosome termini. Telomeres shorten with mitotic cell division, but are maintained in stem cells by the action of telomerase that enzymatically adds nucleotides to the 3' of the chromosome. Telomerase is constituted by the reverse transcriptase (TERT), a RNA compon…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 3 / 3 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 15 / 13 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 28 / 26 | All research grants and scholarships |
| Associated processes | |