CV Lattes
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Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (HCMRP). Hemocentro de Ribeirão Preto (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Medicine (1997), earned a PhD in Clinical Medicine (2003) from the Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), and specialized as a hematologist and hemotherapist (2001) at the Hospital das Clínicas of FMRP-USP. He completed postdoctoral training at the National Institutes of Health in Bethesda, Maryland, USA, where he also worked as a Staff Scientist in the Hematology Branch until 2011.His research interests focus on the mechanisms underlying hematopoietic stem cell failure and on new forms of treatment, including immunotherapies and advanced cell therapies. He was the first to describe mutations in the telomerase gene in human diseases, specifically aplastic anemia and acute leukemia, as a predisposing factor. He demonstrated how hormones can regulate telomerase activity and be used as a treatment. He also demonstrated how telomere shortening can cause liver disease and clonal hematopoiesis.He served as Chair of the Subcommittee on Emerging Gene and Cell Therapies of the American Society of Hematology (2021). He also served as coordinator of Medicine II at Capes and coordinator of Health Area I at Fapesp. He was Pro-Rector for Graduate Studies at the University of São Paulo from 2023 to 2026. He is currently Chief Executive Officer of the Ribeirão Preto Blood Center Foundation and President of the Scientific Council of the Institut Pasteur of São Paulo. (Source: Lattes Curriculum)
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This project aims to ensure an adequate environment for the activities developed at the Cell Therapy Center with the physical adaptation of the laboratory area, including the Hematology laboratory, cell culture room, flow cytometry laboratory, and contracting specialized services to carry out health examinations of the entire mouse colony available to the research center and acquisition o…
The Nucleus of Cellular Therapy - NuTeC will be founded on the union of the Regional Blood Center of Ribeirão Preto (Hemocentro RP) and Butantan. Hemocentro RP expertise in cellular therapy will be added to Butantan excellence in the development and production of health applied products to develop CAR T cell therapy. The activities to be conducted by NuTeC are aligned with the scope of th…
The pandemia caused by the virus SARS-CoV-2 is spreading rapidly around the world, and now reached Brazil. However, its magnitude and consequences are still unknown in this country. In this study, the authors intend to evaluate the impact of convalescent plasma transfusion on patients with severe COVID-19. The clinical picture of this disease is heterogenous, with most patients with mild …
Telomeres are the repetitive nucleotide structures at the end of the linear chromosomes that, when critically short, engage cell senescence, apoptosis, or chromosome instability. In cells with high proliferative demand, telomeres are repaired by telomerase, a reverse transcriptase that adds hexanucleotides to the 3' end of the DNA leading strand. In humans, germline mutations in telomere-…
The present proposal establishes the continuity and expansion of the activities of the National Institute of Science and Technology in Stem Cells and Cell Therapy, one of the National Institutes of Science and Technology created by CNPq/FAPESP in 2008. In that opportunity, we proposed the development of an extensive program of basic and clinical research to understand, isolate, culture an…
(Only some records are available in English at this moment)
Telomeres are nucleotide repeats at chromosome ends that safeguard genome integrity. Their progressive shortening with each cell division acts as a cellular "clock" that, upon reaching critical length, triggers senescence or apoptosis. In telomere biology disorders (telomeropathies), this erosion is accelerated, leading to multisystem manifestations, including immune dysfunction. Neutroph…
Immune aplastic anemia (IAA) is a rare and severe acquired bone marrow failure syndrome characterized by the immune-mediated destruction of hematopoietic stem and progenitor cells, leading to hypocellular bone marrow and consequent pancytopenia. The oligoclonal expansion of autoreactive cytotoxic T lymphocytes, exhibiting an activated phenotype and excessive production of inflammatory cyt…
Telomeres are specialized structures at the ends of chromosomes, formed by repeats of a nucleotides sequence (TTAGGG) and proteins. They are responsible for protecting the ends of chromosomes, preventing DNA damage, genomic instability and loss of genetic material. The lenght of telomeres decreases with each cell division. The gradual loss of throughout life induces senescence, apoptosis …
(Only some records are available in English at this moment)
Telomeres are repeated sequences of nucleotides located at the ends of linear chromosomes. Their function is to prevent the loss of genetic information due to shortening of the lagging strand during DNA replication. Functional alterations that compromise telomeric elongation or cause accelerated erosion imply serious clinical repercussions for individuals affected by these diseases, calle…
As síndromes de insuficiência da medula óssea são um grupo heterogêneo de doençasque possuem como característica a falha de células-tronco hematopoéticas e progenitoras (CTHs), podendo ser causadas por diversos fatores que promovem a redução numérica e funcional das CTHs, dentre eles uma resposta imune por meio de células Th1 citotóxicas que alvejam as CTHs, liberando citocinas e induzind…
The cytotoxic T lymphocyte antigen 4 (CTLA-4) is a cellular receptor that plays a fundamental role as an immune checkpoint, responsible for regulating the immune response and preventing an attack against the body's own cells. On the other hand, tumor cells can exploit this pathway to suppress an immune response, and the CTLA-4 inhibitor ipilimumab is successfully used in the treatment of …
(Only some records are available in English at this moment)
In acquired immune aplastic anemia (immune AA), cytotoxic Th1 cells release cytokines that trigger changes in cell cycle and cell transcription, leading to HSC apoptosis, causing hematopoietic failure. Current treatments are limited and are hampered by the lack of compatible donors and complications. The current standard treatment is related-matched allogeneic hematopoietic stem cell tran…
Telomeres are repetitive sequences of hexanucleotides located at the ends of linear chromosomes that, when critically short, can trigger chromosomal instability, senescence, or apoptosis. Pathogenic variants in genes involved in telomere biology can lead to excessive telomere shortening and diseases most frequently affecting the bone marrow, but also the skin, lungs, liver and predisposin…
Telomeres are the repetitive nucleotide structures at the end of linear chromosomes that, when critically short, engage cell senescence, apoptosis, or chromosome instability. In cells with high proliferative demand, telomeres are repaired by telomerase, a reverse transcriptase that adds hexanucleotides to the 3' end of the DNA leading strand. In humans, germline mutations in telomere-biol…
(Only some records are available in English at this moment)