Márcio Luís Andrade e Silva

CV Lattes ResearcherID ORCID Google Scholar Citations

Universidade de Franca (UNIFRAN). Reitoria (Institutional affiliation from the last research proposal)
Birthplace: Brazil

graduation at Farmácia Industrial from Faculdade de Ciências Farmaceûticas de Ribeirão Preto Usp (1989), master's at Fármacos e Medicamentos from Faculdade de Ciências Farmaceûticas de Ribeirão Preto Usp (1992) and doctorate at Ciências from Faculdade de Filosofia Ciências E Letras de Ribeirão Preto Usp (1999). Has experience in Chemistry, focusing on Chemistry of the Natural Products, acting on the following subjects: lignanas, piper cubeba, (-)-cubebina, atividade antimicrobiana and atividade analgésica. (Source: Lattes Curriculum)

News published in Agência FAPESP Newsletter about the researcher

More items Less items

TITULO

Articles published in other media outlets ( ):

More items Less items

VEICULO: TITULO (DATA)

Research grants

Completed (most recent)

Abstract
Chagas disease and schistosomiasis are considered neglected tropical diseases that affect millions of people in developing and underdeveloped countries. Currently, there are two medicines used for treatment of Chagas disease: nifurtimox (which is already banned in Brazil) and benznidazole. However, these medications have series of serious side effects and have low efficiency. For schistos…
Study of the immunomodulatory activity of lignans and neolignans obtained by partial synthesis and oxidative coupling as a potential in developing new antiparasitic drugs, AP.R
Abstract
The goal of this proposal is the development of two new potential drugs for the treatment of shistosomiasis and Chagas' disease, and both drug candidates were protected by two patents that have been deposited at INPI (Brazilian National Institute for Industrial Protection). These drugs will be developed in collaboration with the pharmaceutical company: JP Indústria Farmacêutica LTDA. Shis…
Synthesis and pre-clinical evaluation of the (-)-o-methylcubebin, drug candidate to treat shistosomiasis, and (-)-hinokinin, drug candidate to treat Chagas' Disease, both obtained from (-)-cubebin isolated from dry seeds of Piper cubeba, AP.PITE
Abstract
In this project is proposed the development of polymeric nanaparticles to be used in the parenteral administration of two drugs (patented in the INPI), using active principles against Chagas disease and schistosomiasis, which are isolated or obtained by partial synthesis. The importance of this project is on the fact that schistosomiasis may affect more than 220 million people in the worl…
Development of polymeric nanaparticles and biodegradable systems containing lignans and evaluation its Chagas disease and schistosomiasis activities in vitro and in vivo, AP.R

See more Completed research grants

(Only some records are available in English at this moment)

Scholarships in Brazil

Completed (most recent)

Abstract
The project proposes the development of a potential drug for the treatment of schistosomiasis from the patent already deposited with the INPI. Schistosomiasis affects over 220 million people a year worldwide, of which 10 million are in Brazil. About 30% of infected individuals are resistant to treatment with drugs on the market. For this, obtained by partial synthesis from the lignan (-)-…
Preparation and characterization of polymeric nanoparticles containing (-)-6,6'-dinitrohinokinin and (±)-licarina-A as potential drugs in the assessment of the schistosomicidal activity, BP.DR
Evaluation of the imunomodulatory effects in Chagas desease of (-)-cubebina and (-)-hinokinin non-encapsulated and encapsulated in nanoparticles, BP.PD
Determination of antibacterial activity of (-)-cubebin and its semi-synthetic derivatives against some microorganisms causers endodontic infections, BP.MS

See more Completed scholarships in Brazil

(Only some records are available in English at this moment)

Virtual Library in numbers * Updated data on August 09, 2025

Total / Available in English

11 / 5	Completed research grants
22 / 7	Completed scholarships in Brazil
33 / 12	All research grants and scholarships

Associated processes

Most frequent collaborators in research granted by FAPESP

Keywords used by the researcher

Chemistry Physical Sciences and Mathematics

Patent applications

PROCESS TO OBTAIN DIBENZYLBUTYROLACTONIC LIGNANS; PROCESS TO OBTAIN SYNTHETIC DERIVATIVES FROM LIGNANES BEARING ANTI-CHAGAS CHEMOPROPHYLACTIC AND THERAPEUTICAL ACTIVITIES DE2003635980 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Sérgio de Albuquerque ; Gustavo Henrique Bianco de Souza ; Jairo Kenupp Bastos ; Rosângela Silva - March 2003, 25

PROCESSO DE OBTENÇÃO DE LIGNANAS DIBENZILBUTIROLACTÔNICAS, PROCESSO DE OBTENÇÃO DE DERIVADOS SINTÉTICOS DE LIGNANAS OSTENTANDO ATIVIDADES QUIMIOPROFILÁTICA E TERAPÊUTICA ANTICHAGÁSICA PI0201237-5 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Sérgio de Albuquerque ; Gustavo Henrique Bianco de Souza ; Jairo Kenupp Bastos ; Rosângela Silva - March 2002, 25

PROCESSO DE OBTENÇÃO DE LIGNANAS DIBENZILBUTIROLACTÔNICAS, TETRAHIDROFURÂNICAS E DE SEUS DERIVADOS SINTÉTICOS E SEMI-SINTÉTICOS, SUAS ATIVIDADES ANALGÉSICA E ANTIINFLAMATÓRIA, FORMULAÇÕES TÓPICAS E/OU SISTÊMICAS CONTENDO TAIS LIGNANAS E RESPECTIVO MÉTODO TERAPÊUTICO PI0501542-1 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Jairo Kenupp Bastos ; Paulo Marcos Donate ; Sergio de Albuquerque ; Rosangela da Silva - April 2005, 28

PROCESSO DE OBTENÇÃO DE DERIVADOS SINTÉTICOS E SEMI-SINTÉTICOS DE LIGNANAS, SUAS ATIVIDADES ANTIPARASITÁRIAS E RESPECTIVAS FORMULAÇÕES FARMACÊUTICAS, ENGLOBANDO O MÉTODO TERAPÊUTICO UTILIZANDO TAIS LIGNANAS NO TRATAMENTO DE PARASITOSES PI0503951-7 - Acef S/A; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Rosângela da Silva ; Vanderlei Rodrigues ; Olavo dos Santos Pereira Júnior ; Ademar Alves da Silva Filho ; Paulo Marcos Donate ; Sérgio de Albuquerque ; Jairo Kenupp Bastos - July 2005, 15

PROCESS TO OBTAIN DIBENZYLBUTYROLACTONIC LIGNANS; PROCESS TO OBTAIN SYNTHETIC DERIVATIVES FROM LIGNANES BEARING ANTI-CHAGAS CHEMOPROPHYLACTIC AND THERAPEUTICAL ACTIVITIES US10/508,875 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Sérgio de Albuquerque ; Gustavo Henrique Bianco de Souza ; Jairo Kenupp Bastos ; Rosângela Silva - March 2003, 25

PROCESS TO OBTAIN DIBENZYLBUTYROLACTONIC, TETRAHYDROFURANIC LIGNANS AND THEIR SYNTHETIC AND SEMI-SYNTHETIC DERIVATIVES, THEIR ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES, TOPICAL AND/OR SYSTEMIC FORMULATIONS CONTAINING SAID LIGNANS AND THEIR RESPECTIVE THERAPEUTIC METHOD US11/912,645 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Jairo Kenupp Bastos ; Paulo Marcos Donate ; Sergio de Albuquerque ; Rosangela da Silva - April 2006, 28

PROCESS TO OBTAIN SYNTHETIC AND SEMI-SYNTHETIC LIGNAN DERIVATIVES, THEIR ANTIPARASITIC ACTIVITIES AND CORRESPONDING PHARMACEUTICAL FORMULATIONS, INCLUDING THE THERAPEUTIC METHOD USING SAID LIGNAN FOR THE TREATMENT OF PARASITOSIS US11/995,789 - Acef S/A; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Rosângela da Silva ; Vanderlei Rodrigues ; Olavo dos Santos Pereira Júnior ; Ademar Alves da Silva Filho ; Paulo Marcos Donate ; Sérgio de Albuquerque ; Jairo Kenupp Bastos - July 2006, 14

PROCESS TO OBTAIN DIBENZYLBUTYROLACTONIC LIGNANS; PROCESS TO OBTAIN SYNTHETIC DERIVATIVES FROM LIGNANES BEARING ANTI-CHAGAS CHEMOPROPHYLACTIC AND THERAPEUTICAL ACTIVITIES US11/951,460 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Sérgio de Albuquerque ; Gustavo Henrique Bianco de Souza ; Jairo Kenupp Bastos ; Rosângela Silva - December 2007, 06

PROCESS TO OBTAIN DIBENZYLBUTYROLACTONIC LIGNANS; PROCESS TO OBTAIN SYNTHETIC DERIVATIVES FROM LIGNANES BEARING ANTI-CHAGAS CHEMOPROPHYLACTIC AND THERAPEUTICAL ACTIVITIES EP20030709465 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Sérgio de Albuquerque ; Gustavo Henrique Bianco de Souza ; Jairo Kenupp Bastos ; Rosângela Silva - March 2003, 25

PROCESS TO OBTAIN DIBENZYLBUTYROLACTONIC, TETRAHYDROFURANIC LIGNANS AND THEIR SYNTHETIC AND SEMI-SYNTHETIC DERIVATIVES, THEIR ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES, TOPICAL AND/OR SYSTEMIC FORMULATIONS CONTAINING SAID LIGNANS AND THEIR RESPECTIVE THERAPEUTIC METHOD EP20060721642 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Jairo Kenupp Bastos ; Paulo Marcos Donate ; Sergio de Albuquerque ; Rosangela da Silva - April 2006, 28

PROCESS TO OBTAIN SYNTHETIC AND SEMI-SYNTHETIC LIGNAN DERIVATIVES, THEIR ANTIPARASITIC ACTIVITIES AND CORRESPONDING PHARMACEUTICAL FORMULATIONS, INCLUDING THE THERAPEUTIC METHOD USING SAID LIGNAN FOR THE TREATMENT OF PARASITOSIS EP20060761026 - Acef S/A; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Rosângela da Silva ; Vanderlei Rodrigues ; Olavo dos Santos Pereira Júnior ; Ademar Alves da Silva Filho ; Paulo Marcos Donate ; Sérgio de Albuquerque ; Jairo Kenupp Bastos - July 2006, 14

PROCESS TO OBTAIN DIBENZYLBUTYROLACTONIC LIGNANS; PROCESS TO OBTAIN SYNTHETIC DERIVATIVES FROM LIGNANES BEARING ANTI-CHAGAS CHEMOPROPHYLACTIC AND THERAPEUTICAL ACTIVITIES JP2011098968 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Sérgio de Albuquerque ; Gustavo Henrique Bianco de Souza ; Jairo Kenupp Bastos ; Rosângela Silva - December 2007, 06

PROCESS TO OBTAIN DIBENZYLBUTYROLACTONIC LIGNANS; PROCESS TO OBTAIN SYNTHETIC DERIVATIVES FROM LIGNANES BEARING ANTI-CHAGAS CHEMOPROPHYLACTIC AND THERAPEUTICAL ACTIVITIES PCT/BR2003/000045 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Sérgio de Albuquerque ; Gustavo Henrique Bianco de Souza ; Jairo Kenupp Bastos ; Rosângela Silva - March 2003, 25

PROCESS TO OBTAIN DIBENZYLBUTYROLACTONIC, TETRAHYDROFURANIC LIGNANS AND THEIR SYNTHETIC AND SEMI-SYNTHETIC DERIVATIVES, THEIR ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES, TOPICAL AND/OR SYSTEMIC FORMULATIONS CONTAINING SAID LIGNANS AND THEIR RESPECTIVE THERAPEUTIC METHOD PCT/BR2006/000084 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Jairo Kenupp Bastos ; Paulo Marcos Donate ; Sergio de Albuquerque ; Rosangela da Silva - April 2006, 28

PROCESS TO OBTAIN SYNTHETIC AND SEMI-SYNTHETIC LIGNAN DERIVATIVES, THEIR ANTIPARASITIC ACTIVITIES AND CORRESPONDING PHARMACEUTICAL FORMULATIONS, INCLUDING THE THERAPEUTIC METHOD USING SAID LIGNAN FOR THE TREATMENT OF PARASITOSIS PCT/BR2006/000144 - Acef S/A; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Márcio Luís Andrade e Silva ; Rosângela da Silva ; Vanderlei Rodrigues ; Olavo dos Santos Pereira Júnior ; Ademar Alves da Silva Filho ; Paulo Marcos Donate ; Sérgio de Albuquerque ; Jairo Kenupp Bastos - July 2006, 14

Please report errors on the page using this form.

Short URL

Abstract

Abstract

Abstract

Abstract