CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
ALRO has been a Full Professor at the Institute of Biology of the State University of Campinas (UNICAMP) since 2016. He graduated in Biological Sciences from Universidade Estadual Paulista (UNESP) in 1993, and obtained his master's degree in Cell Biology and his doctorate in Cell Biology from Universidade Estadual de Campinas (UNICAMP) in 1996 and 1999, respectively. He is the coordinator of the Laboratory of Nerve Regeneration at the Institute of Biology / UNICAMP. His research focuses on the regeneration of the CNS and PNS after injury and repair, with an emphasis on synaptic plasticity and glial responses. He is particularly interested in the survival of spinal motor neurons after proximal lesions and during the development of neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis and Duchenne muscular dystrophy. (Source: Lattes Curriculum)
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Regeneration of the Nervous System is a challenge that endures to the present day, given the complexity of events that follow trauma or during neurodegenerative diseases. It is well established that the Central Nervous System (CNS) contrasts with the Peripheral Nervous System (PNS) in terms of regenerative potential, the latter being more likely to restore its structure and function. Howe…
The Aperio VERSA is a comprehensive digital pathology scanner, designed and developed to support the diverse imaging needs of cutting edge research facilities. The combination scanner is optimized for precision scanning of brightfield and fluorescent samples, with the accuracy and resolution required for FISH . From tissue-based and proteomic markers, to subcellular, molecular and in-situ…
The present proposal aims at the acquisition of an instrument that employs the technology called serial block-face images (SBF). This is characterized by the use of a system that combines ultramicrotomy and in situ imaging of samples embedded in resin through an ultramicrotome included in the vacuum chamber of a scanning electron microscope, with field emission source (MEVFEG). While obta…
(Only some records are available in English at this moment)
Functional recovery of the peripheral nervous system (PNS) injured is frequently and highly variable, leading to persistent sensory/motor deficits with poor quality of life and productivity. Biomimetic biomaterials that release continuously bioactive molecules offer a promising approach to optimizing the microenvironment during nerve regeneration. New technologies such as three-dimensiona…
Motor coordination involves specific neural processes ranging from the perception of stimuli to the achievement of the response, being dependent on delicate sensory-motor integration, which is particularly evident in the spinal cord. Spinal root injuries can lead to motor, sensibility and autonomic losses. This type of lesion constitutes a significant medical problem and usually affects t…
The present application aims at upgrading the infrastructure of the Institute of Biology / Unicamp. In this way, the upgrade of the Institute network hardware, animal facilities improvements, electric instalation renewal and establishement of a NB3 lab are proposed. (AU)
(Only some records are available in English at this moment)
Multiple sclerosis (MS) is a neurodegenerative disease that mainly affects young adults and is characterized by demyelination in the central nervous system, resulting in severe neurological symptoms. The pathology involves the action of immune cells that attack myelin, leading to various dysfunctions. Current treatment is based on immunosuppressive drugs which, although effective, can cau…
Laminectomy is a widely used procedure in surgeries to expose and decompress the spinal cord and nerve roots. However, there are limitations such as the loss of bone support, excessive fibrous tissue formation, adhesions, and secondary compression of nervous tissue. To create a barrier between soft and mineralized tissues and provide greater mechanical support to the spinal cord, artifici…
Peripheral nerve transection is a common clinical problem that affects millions of patients each year and requires surgical repair usually carried out by end-to-end neurorrhaphy. However, neuropathic pain, paralysis, and muscle weakness may persist for several months or even become permanent. After neurotmesis, Wallerian degeneration (WD) takes place in the distal stump, and axonal regene…
(Only some records are available in English at this moment)
Central nervous system injuries are highly complex, in terms of consequences and treatment management, due to the sensitivity and degree of interaction of its components. In view of the urgency of effective treatments after spinal cord injuries, different molecules have been investigated. In this context, cannabidiol (CBD) proved to be efficient in several models, in which it contributed …
Duchenne Muscular Dystrophy (DMD) is a severe genetic muscle disease characterized by failures in the synthesis of the protein dystrophin, inducing progressive muscle degeneration and weakness, leading the patient to death. The progression of the disease results in synaptic changes in the CNS as well as in the neuromuscular junctions. In addition, the axons of the neurons enter into a cyc…
Spinal nerve root lesions can occur after trauma and pathological processes, leading to dysfunction of brachial and lumbosacral plexuses. These lesions can be avulsion or crush, generating neuronal death and synaptic loss, consequently, causing motor and sensory dysfunctions. Local inflammation is mediated by astroglial and microglial cells, giving rise to a pro-inflammatory profile. Drug…
(Only some records are available in English at this moment)
Peripheral nerve injuries commonly generate persistent sensory/motor deficits even after surgical repair. Biomaterials for the controlled release of neuroregenerative molecules provide a promising approach for regulating the microenvironment during nerve regeneration. In this study, nerve wraps from a natural-based bioink made of gelatin methacryloyl (GelMA) combined with Laponite nanopar…
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting the motor system. The cause of the disease is still unknown, but some protein mutations have been linked to the pathological process. Previously, it has been considered that immune abnormalities might contribute to the pathogenesis of disease. However, more recently it has become apparent that the immune re…
Dorsal root injury leads either to chronic pain or paresthesia, resulting in loss of function of the affected arm, even when motor roots remain intact, due to damage to proprioceptive fibers which lose contact with motoneurons. Regeneration through the dorsal root entry zone is difficult due to inhibitory molecules within the Central Nervous System, but possible in crushing injuries. In t…
(Only some records are available in English at this moment)
| 7 / 7 | Ongoing grants |
| 34 / 31 | Completed research grants |
| 9 / 9 | Ongoing scholarships in Brazil |
| 52 / 46 | Completed scholarships in Brazil |
| 7 / 6 | Completed scholarships abroad |
| 109 / 99 | All research grants and scholarships |
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