CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1993), master's at General Biology from Universidade Estadual de Campinas (1996) and ph.d. at General Biology from Universidade Estadual de Campinas (1999). Has experience in Morphology, focusing on Anatomy, acting on the following subjects: c57bl6j, nervo ciático, tubulização, regeneração nervosa and pedegeneração. (Source: Lattes Curriculum)
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Functional recovery of the peripheral nervous system (PNS) injured is frequently and highly variable, leading to persistent sensory/motor deficits with poor quality of life and productivity. Biomimetic biomaterials that release continuously bioactive molecules offer a promising approach to optimizing the microenvironment during nerve regeneration. New technologies such as three-dimensiona…
Functional recovery of the peripheral nervous system (PNS) injured is frequently and highly variable, leading to persistent sensory/motor deficits with poor quality of life and productivity. Biomimetic biomaterials that release continuously bioactive molecules offer a promising approach to optimizing the microenvironment during nerve regeneration. New technologies such as three-dimensiona…
Motor coordination involves specific neural processes ranging from the perception of stimuli to the achievement of the response, being dependent on delicate sensory-motor integration, which is particularly evident in the spinal cord. Spinal root injuries can lead to motor, sensibility and autonomic losses. This type of lesion constitutes a significant medical problem and usually affects t…
(Only some records are available in English at this moment)
The present application aims at upgrading the infrastructure of the Institute of Biology / Unicamp. In this way, the upgrade of the Institute network hardware, animal facilities improvements, electric instalation renewal and establishement of a NB3 lab are proposed. (AU)
The present application aims at upgrading the infrastructure of the Institute of Biology / Unicamp. In this way, the instalation of different gases stations, upgrading datacenter infrastructure and renovation of laboratories are proposed. (AU)
The present application aims at upgrading the infrastructure of the Institute of Biology / Unicamp. In this way, the instalation of different gases stations, upgrading datacenter infrastructure and renovation of laboratories are proposed. (AU)
(Only some records are available in English at this moment)
Peripheral nerve injuries are frequent and affect the nervous system, and may result from a wide variety of events, such as trauma, tumors, and musculoskeletal disorders. The Endocannabinoid System, involved in neuroprotection and plasticity events after injuries, has two receptors discovered so far. The first one, CB1, is more abundantly expressed in the Central Nervous System, while the…
The injuries to the brachial plexus (BPI) are the worst of all those sustained by the peripheral nerves. Ventral root avulsion (VRA) is an experimental approach to study BPI, which induces death of the vast majority of the affected adult motoneurons, triggering a strong glial reaction as well as synaptic detachment. To overcome the degenerative effects of VRA, combinatorial approaches cou…
(Only some records are available in English at this moment)
Compressive root lesions are characterized by changes in the spinal cord's nervous microenvironment. Among these changes, the excitotoxic effect caused by glutamate, gliosis, and the subsequent maladaptive plasticity events stand out. Glutamate is an excitatory neurotransmitter that activates, among others receptors, the NMDAr ionotropic receptor. In light of the findings of how excessive…
Spinal cord injuries generate significant degeneration of motoneurons, loss of synapses, formation of glial scar and chronic inflammation, hampering functional recovery. In order to provide neuroprotection and regeneration, early surgical interventions and treatments that positively modify the neuronal microenvironment are necessary. In this sense, the use of neuroprotective and chemotact…
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects motor neurons progressively, causing progressive weakness and muscle atrophy, leading to death frequently due to respiratory arrest. ALS can be classified into two main types, which differ in etiology. The familial type has a hereditary origin, while sporadic type represents the vast majority of cases (90%), a…
(Only some records are available in English at this moment)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting the motor system. The cause of the disease is still unknown, but some protein mutations have been linked to the pathological process. Previously, it has been considered that immune abnormalities might contribute to the pathogenesis of disease. However, more recently it has become apparent that the immune re…
Dorsal root injury leads either to chronic pain or paresthesia, resulting in loss of function of the affected arm, even when motor roots remain intact, due to damage to proprioceptive fibers which lose contact with motoneurons. Regeneration through the dorsal root entry zone is difficult due to inhibitory molecules within the Central Nervous System, but possible in crushing injuries. In t…
The interaction between motoneurons and glial cells has a crucial role for survival, regulation of functional state and synaptic connectivity in the spinal cord. Understanding the basic functions of glial cells and motoneuron interaction will contribute to the development of new strategies in order to promote regeneration after injury. After lesion, glial cells also undergo a series of mo…
(Only some records are available in English at this moment)
| 5 / 5 | Ongoing research grants |
| 32 / 29 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 41 / 35 | Completed scholarships in Brazil |
| 6 / 5 | Completed scholarships abroad |
| 90 / 80 | All research grants and scholarships |
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