Miguel Luiz Batista Junior

• Abstract

  This paper reports on a quasi-experimental study that aimed to identify changes in muscle function (i.e., mobility, maximal walking speed, lower limb muscle strength, balance, and transfer capacity), cognition (i.e., executive function) and hemodynamic parameters of community-dwelling Brazilian older adults during a six-month multicomponent exercise program (MCEP). A total of 436 communit…

  Exercício Multicomponente na Função Física, Cognição e Parâmetros Hemodinâmicos de Adultos Idosos da Comunidade: Um estudo quasi-experimental, PUB.ART

• Abstract

  Cancer-induced cachexia, characterized by systemic inflammation, body weight loss, adipose tissue (AT) remodeling and muscle wasting, is a malignant metabolic syndrome with undefined etiology. Here, we show that both genetic ablation and pharmacological inhibition of TLR4 were able to attenuate the main clinical markers of cachexia in mice bearing Lewis lung carcinoma (LLC). AT remodellin…

  Ausência do Receptor Toll-Like-4 Suprime o Remodelamento do Tecido Adiposo e Aumenta o tempo de vida na Síndrome de Caquexia do Câncer, PUB.ART

• Abstract

  Physical exercise has beneficial effects on metabolic diseases, and a combined therapeutic regimen of regular exercise and pharmaceutical treatment is often recommended for their clinical management. However, the mechanisms by which exercise produces these beneficial effects are not fully understood. Myokines, a group of skeletal muscle (SkM) derived peptides may play an important part in…

  Papel das Myokines Induzidas pelo Exercício Físico no Crosstalk entre Tecido Adiposo-Muscular: Uma Revisão do estado da arte e as Implicações para a Saúde e Doenças Metabólicas, PUB.ART

(Only some records are available in English at this moment)

• Abstract

  Cachexia is a multifactorial syndrome characterized by continuous reduction of total body mass that cannot be fully reversed by nutritional support. This syndrome leads to progressive functional impairment and mainly affects skeletal muscle and adipose tissue (AT). In the development of cachexia, AT is affected early, being an endocrine organ constituted of several cell types, including, …

  The role of type 1 pericyte in the differentiation to beige adipocytes in NG2-CREERTM and R26RRFP mice with cancer-associated cachexia, BP.IC

• Abstract

  Cachexia is a multifactorial syndrome, related to systemic inflammation, metabolic chaos and especially with the continuous reduction of adipose and skeletal muscle mass. Adipose tissue (TA) is early affected by the syndrome and plays an important role in its development. It is considered a heterogeneous organ divided into white TA (TAB) and brown TA (TAM), each with its distinct morpholo…

  Evaluation of beige adipocyte induction by cancer-associated cachexia in adipocytes knockout for TLR4, BP.IC

• Abstract

  The adipose tissue is an important organ due to its high adaptation power to the environmental adversities beside controlling the energy stock. The white adipose tissue (WAT) provides substrates for the organism energy maintenance and the brown adipose tissue (BAT) is one of those responsible for the heat production through the adaptative thermogenesis process. It has been described in li…

  Verification of mitochondrial network morphology in the process of browning induced by cold exposure in C57BL/6 mice, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Cachexia is characterized as a syndrome that affects multiple compartments and systems of the tumor-bearing organism, breaking the natural state of balance between the systems, leading to metabolic "chaos." It is highly prevalent in cancer patients, especially in patients with gastrointestinal cancer (> 60%) and in more than 25% of patients; it is the leading cause of death. Recently, sev…

  TLR4 as crossroad of inflammation and energy metabolism: Role of adipose tissue in cancer cachexia, BE.PQ