Pedro Paulo Chaves de Souza

• Abstract

  This bilateral research collaboration was first discussed in July 2015 during a workshop organized by UNESP, where Dr. Xiao and Dr. de Souza discussed possibilities for a collaborative project to investigate the mechanisms involved in osteoimmunomodulation by biomaterials. Dr. de Souza was the recipient of a prestigious Brazilian Young Investigator grant in 2014 (Young Investigator # 2014…

  Molecular mechanisms involved in osteoimmunomodulatory properties of biomaterials, AP.R SPRINT

• Abstract

  Besides the classical action of the kallikrein-kinin system (KKS) in the modulation of the vascular tonus, this system is also involved in different pathologies, some of them being inflammatory in nature. Inflammatory processes in the vicinity of the skeleton generally leads to bone loss, and in vitro models demonstrate that kinins may participate of inflammatory bone resorption by activa…

  The effect of bradykinin on osteoclastogenesis in vitro and LPS-induced bone resorption in vivo, AP.JP

• Abstract

  Inflammatory reactions close to the skeleton generally lead to bone loss, for example in pathological conditions such as rheumatoid arthritis, periodontal disease, loosened joint prosthesis and peri-implantitis. Some of these reactions are caused by infection. In periodontitis, Porphyromonas gingivalis (P.g.) is an important pathogenic microorganism. Besides having lipopolysaccharide in i…

  The role of IL-4 on RANKL induced by lipoproteins in osteoblasts, BP.IC

• Abstract

  Besides the classical action of the kallikrein-kinin system (KKS) in the modulation ofthe vascular tonus, this system is also involved in different pathologies, some of thembeing inflammatory in nature. Inflammatory processes in the vicinity of the skeletongenerally leads to bone loss, and in vitro models demonstrate that kinins mayparticipate of inflammatory bone resorption by activating…

  Effect of Bradykinin on osteoclastogenesis in vitro, BP.IC

• Abstract

  Besides the classical action of the kallikrein-kinin system (KKS) in the modulation of the vascular tonus, this system is also involved in different pathologies, some of them being inflammatory in nature. Inflammatory processes in the vicinity of the skeleton generally leads to bone loss, and in vitro models demonstrate that kinins may participate of inflammatory bone resorption by activa…

  Effect of Bradykinin on bone resorption induced by LPS in alive, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Bradykinin is a nonapeptide involved in inflammation, triggering to the inflammatory signs and symptoms when injected in animal tissues. It acts through the B2 receptor that is constitutively expressed in most tissues, and after activation this receptor is desensitized. The metabolite DABK acts through another receptor, the B1 receptor, that shares 36% identity with the B2 receptor, but i…

  Signaling pathways involved in the regulation of COX2 expression mediated by kinin B1 and B2 receptors agonists, BE.EP.IC