CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (2002), master's at General Biology from Universidade Estadual de Campinas (2005) and ph.d. at General Biology from Universidade Estadual de Campinas (2009). Has experience in Morphology, acting on the following subjects: prostate, mmps, stroma, castration and peixe. (Source: Lattes Curriculum)
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The concept of the Developmental Origins of Health and Disease (DOHaD) establishes that adverse exposures during critical periods of development can predispose offspring to a higher incidence of Non-Communicable Chronic Diseases (NCDs) throughout life. Our group has been investigating the effects of Maternal Protein Restriction (MPR) on offspring health, revealing morphofunctional alterat…
The concept of the Developmental Origin of Health and Disease (DOHaD) seeks to establish correlations between exposure to adverse conditions in early life and the development of disease in adulthood. Epidemiological and experimental studies have shown that some types of cancer can originate early in life, including prostate cancer (PCa). Although the mechanisms involved in the development…
AbstractIn the last decades, it has been observed an increase in the incidence of diseases related to alterations in the metabolism, that affect both children and adults. Among the most prevalent are obesity, diabetes, cardiovascular diseases and even some types of cancer. Epidemiological evidence shows that chronic diseases can originate from insults sustained during intrauterine develop…
The developmental origins of health and disease concept links adult diseases with early-life exposure to inappropriate environmental conditions. Intrauterine and postnatal malnutrition may lead to an increasedincidence of type 2 diabetes, obesity, and cardiovascular diseases. Maternal malnutrition (MM) has also been associated with prostate carcinogenesis. However, the molecular mechanism…
(Only some records are available in English at this moment)
The concept of Developmental Origins of Health and Disease (DOHaD) postulates that impacts during critical developmental windows (pregnancy and lactation) can increase the risk of developing metabolic diseases in offspring. One such adversity is maternal malnutrition since epidemiological and experimental data have already shown that this condition increases the risk of cardiovascular dis…
Adverse gestational conditions can lead to irreversible morphofunctional changes in the offspring, a concept known as Developmental Origins of Health and Disease (DOHaD). Maternal protein restriction (MPR), a model used in DOHaD studies, has been associated with an increased incidence of cardiovascular and renal diseases, as well as affecting reproductive parameters and the development of…
The concept of DOHaD (Developmental Origins of Health and Disease) aims to understand how early developmental events are associated with the occurrence of diseases in adulthood and aging. In this context, maternal protein restriction (MPR) in rodents is widely used as an experimental model to investigate these processes. Evidence indicates that MPR negatively affects insulin secretion and…
(Only some records are available in English at this moment)
The DOHaD (Developmental Origins of Health and Disease) approach seeks to establish a correlation between the incidence of diseases in adulthood and aging in light of the events suffered during the beginning of development. One of its most used models for DOHaD studies is the submission of rodents to maternal protein restriction (RPM). Experimental studies already demonstrate that it is r…
The DOHaD concept (Developmental Origin of Health and Disease) seeks to establish the correlation between the incidence of diseases in adult life and in aging, in view of the events suffered during early development. One of the most used models for DOHaD studies is the submission of rodents to maternal protein restriction (PMR). Experimental studies have already shown that it is responsib…
The DOHaD approach (Developmental Origins of Health and Disease) seeks to establish the correlation between the incidence of diseases in adult life and in aging in view of the events suffered during early development. One of his most used models for DOHaD studies is the submission of rodents to maternal protein restriction (PMR). Experimental studies have already shown that it is responsi…
(Only some records are available in English at this moment)
Maternal obesity during pregnancy increases the incidence of chronic non-communicable diseases in the offspring. The placenta, essential for the exchange of nutrients and oxygen between mother and embryo/fetus, is impacted by maternal malnutrition, with changes in placental weight, triglyceride content, and calcification areas, leading to reduced nutrient exchange. Consequently, fetuses o…
The pancreas, a crucial organ implicated in digestion and blood sugar regulation, is frequently impacted by aggressive forms of cancer that exhibit rapid dissemination to neighboring tissues and organs. Pancreatic cancer poses a considerable challenge for early detection, often resulting in delayed diagnoses and advanced disease stages, thereby contributing to elevated mortality rates. Pr…
The concept of Developmental Origin of Health and Disease (DOHaD) seeks to establish the correlation of diseases in adult life with events occurring during intrauterine development and/or early childhood. One of the models used for DOHaD studies is the submission of rodents to maternal protein restriction (MPR). MPR is responsible for the delay in the normal development of the prostate, i…
(Only some records are available in English at this moment)