CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduation in Biological Sciences by Universidade Federal de São Paulo (UNIFESP, 1981), Master in Pharmacology (UNIFESP, 1989) and doctorate in Pharmacology (UNIFESP, 1991). Has experience in Nutrition, acting on the following subjects: obesity, central nervous system control of food intake, serotonin, brain microdialysis, high-fat diets, intrauterine growth restriction, proteomics. (Source: Lattes Curriculum)
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The relationship between adverse nutritional conditions during pregnancy and the development of metabolic disorders in adulthood is well established. Several studies have shown that intrauterine growth restriction (IUGR)-induced obesity is related to hypothalamic disorders. In a previous study, we showed that IUGR induced changes in glucose metabolism and increased the flux through the he…
The ingestion of hyperlipidic and hypercaloric diet is considered as major factor in the obesity genesis, which led to an increase in the ROS production, that is related to many metabolic alterations associated to the obesity. The increase in intestinal permeability may be due to the excessive intake of a hypercaloric diet, which may lead to an increase in LPS translocation into the blood…
Menopause is associated with increased risk to develop obesity but the mechanisms involved are not fully understood. We have shown that Ginkgo biloba (GbE) improved diet-induced obesity. Since GbE might be effective in the treatment of obesity related to menopause, without bringing the side effects of hormone replacement therapy, we investigated the effect of GbE on hypothalamic systems c…
(Only some records are available in English at this moment)
The hypothalamic metabolism of glucose plays an important role in the central control of glycemia and food intake, aspects that are dysregulated in obesity and diabetes. In astrocytes, glucose metabolism generates pyruvate, which is converted to lactate by the enzyme lactate dehydrogenase A (LDH-A). The lactate is then transferred to neurons where it is reconverted to pyruvate by the enzy…
Energy homeostasis depends on the perfect interaction between energy intake and expenditure, leading to the stability of body fat stores. Obesity is nowadays a public health issue and the intake of high-fat diets contributes to the obesity epidemic. We have shown that high-fat intake increases body weight and fat content. Nutrients in the diet, such as glucose and fatty acids, reach the c…
Menopause is defined as the absence of menstrual cycles for at least twelve months. From that event a number of changes will occur, women will become more susceptible to the development of several diseases, including osteoporosis, coronary artery disease, insulin resistance and obesity. Obesity, which is progressively becoming one of the most prevalent diseases in the Western world, is du…
(Only some records are available in English at this moment)
| 20 / 9 | Completed research grants |
| 11 / 6 | Completed scholarships in Brazil |
| 31 / 15 | All research grants and scholarships |
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