CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Instituto de Biociências da Usp (1996), master's at Fisiopatolgia Experimental from Faculdade de Medicina da Usp (2000) and doctorate at Emergências Clínicas from Faculdade de Medicina da Usp (2007). Has experience in Medicine, focusing on Pneumology, acting on the following subjects: tractus pneumaticus, airway inflammation and guinea pig. (Source: Lattes Curriculum)
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There is evidence of the importance of the autoimmunity mechanism in the progression of COPD due to the chronic inflammatory process induced by exposure to cigarette smoke. As the inflammatory process progresses, the adaptive immune response mediated by Th17 lymphocytes plays an important role in this process, and its occurrence has been partly attributed to a failure in controlling the i…
Experimental therapy laboratory I (LIM-20) is a multidisciplinary group of researchers who have been working for several years on the mechanisms of asthma and chronic obstructive pulmonary disease (COPD) development, with a focus in the mechanisms of modulation and pathophysiology of these combining experimental and clinical studies in patients with asthma and COPD. Both in clinical pract…
Smoking is one of the main risk factors for the development of cardiovascular and pulmonary diseases and different types of cancer. In addition, it is also an important factor for the exacerbation of diseases that affect the musculoskeletal system, such as osteoarthritis. In previous studies developed by our group, we have already demonstrated the deleterious effects of exposure to cigare…
Previous studies have shown that failure to control the inflammatory process associated with T helper (Th17) / regulatory T (Treg) response imbalance contributes to the progression of COPD. We also present the importance of intracellular signaling mediated by STAT (Activator of Transcription Protein) and SOCS (Suppressor Of Cytokine Signaling) proteins in this process. Since the role of p…
In a previous study we demonstrated that COPD smokers showed decreased regulatory T cells density (Treg) with a decrease for their immunosuppressant interleukins TGF beta and IL-10 compared to smokers without obstruction. Also, it was also detected increased positive cells density for IL-17, featuring a Th17 response profile in these individuals. Considering the role of intracellular prot…
(Only some records are available in English at this moment)
Chronic obstructive pulmonary disease (COPD) is characterized by slow and progressive limitation ofairflow that is not fully reversible, with chronic bronchitis and pulmonary emphysema being theits main manifestations. Smoking is considered the main risk factor fordevelopment of the disease, providing a chronic inflammatory process mediated by immunityinnate and adaptive. In previous stud…
Obstructive respiratory diseases - asthma and COPD - have been widely studied, however, in recent years, a variant of these diseases, with characteristics of both, called asthma-overlap syndrome-COPD (ACO) has aroused interest in the scientific community. However, studies are lacking that offer a better understanding of the pathophysiology of the overlap of asthma and COPD and the mechani…
Asthmatic patients present a Th2 response profile, with an increase in cells TCD4+ and increased eosinophils around the airways, while COPD patients present a Th1 immune response profile, an increase in CD8+ T cells and an increase of neutrophils (Brusselle et al., 2011; Cosio et al., 2009). Our group has already demonstrated studies in an experimental model of COPD and in tissues from CO…
The importance of the adaptive immune response, characterized by an increase in Th17 lymphocytes, as well as interleukin-17 (IL-17) in the development and progression of chronic obstructive pulmonary disease (COPD), has already been described in the literature. The role of obesity in the exacerbation of different pre-existing diseases mediated by the TH17 response has also been described.…
Although asthma and chronic obstructive pulmonary disease are described as distinct clinical entities, more recently, discussions about when COPD and asthma are expressions of the same disease that affects the respiratory system have intensified (1). The use of animal models helps to better understand the pathophysiological mechanisms involved in the development of different diseases, inc…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 10 / 9 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 12 / 11 | Completed scholarships in Brazil |
| 26 / 24 | All research grants and scholarships |
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