CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Medical degree from the University of Taubaté São Paulo, Brasil (1973) and PhD in Sciences (Human Physiology) from the University of São Paulo (1978). Currently is a full professor at the University of São Paulo, Institute of Biomedical Sciences, Department of Physiology and Biophysics with experience in the field of Physiology, with emphasis on Insulin secretion, acting mainly on the following topics: mechanisms of insulin secretion, isolated islets, NADPH oxidase and redox state of insulin secreting cells. (Source: Lattes Curriculum)
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NADPH oxidases (NOX) are reactive oxygen species (ROS)-producing isoenzymes. The isoenzymes NOX1, NOX2 and NOX4 are expressed in pancreatic beta cells and our preliminary studies indicate expression of the isoenzymes DUOX1 and DUOX2 in beta cells in vitro. However, this remains to be confirmed in vivo. In addition to oxidative stress, ROS participate in signal transduction and this functi…
Diabetes mellitus is characterized by failures in the action and/or the production of insulin, which leads to the inability to maintain glycemic homeostasis. Type 1 diabetes is characterized by inflammation of the pancreatic islets (insulitis) causing dysfunction and death of the islet cells. Local production of pro-inflammatory cytokines, such as IL-1², TNF-± and IFN-³, is directly relat…
Progression to type 2 diabetes correlates with oxidative damage in beta-cells due to lipotoxicity, however the mechanisms underlying this progressive beta-cell failure are still uncertain. Thus in this study we aim too determine the effect of prolonged culture in the presence of saturated or polyunsaturated fatty acids on the functional integrity of the pancreatic beta cell. We hypothesiz…
(Only some records are available in English at this moment)
Obesity-associated diabetes is increasing all over the world. Glucose and lipids concentration, metabolism and signaling pathways are well studied in the context of diabetes, however less is known about the metabolism of amino acids and signaling pathways involving in insulin secretion and a possible relationship with the NAD(P)H oxidase complex. The concentration of the most abundant ami…
Insulin secretion is stimulated by circulating glucose, but the fatty acid (FA) may influence the secretory process induced by glucose (GSIS). The É-3 polyunsaturated FA interfere with several physiological processes, such as regulation of the concentration of plasma lipids, immune function and cardiovascular, peripheral insulin action, neuronal development and visual function. É-3 FA hav…
The pancreatic islets are composed mostly of B cells that secrete insulin, and have their function modulated by the concentration of nutrients present in the circulation, including, glucose, recognized as the major insulin secretagogue. Metabolic disorders such as metabolic syndrome, obesity and insulin resistance are characterized by an imbalance in glucose homeostasis and deficiency in …
(Only some records are available in English at this moment)
Oxidative stress has long been proposed as a unifying mechanism linking excessive nutrient intake, insulin resistance, the metabolic syndrome, and diabetes. Although in vitro studies suggest that reactive oxygen species (ROS) play an important role in the development of insulin resistance and type 2 diabetes, virtually nothing is known about how in vivo redox changes are modulated under t…
Oxidative stress has been implicated as a contributor to both the onset and the progression of diabetes and its associated complications. Some of the consequences of increased reactive oxygen species (ROS) production are the development of insulin resistance, beta-cell dysfunction, impaired glucose tolerance, and mitochondrial dysfunction, which can lead ultimately to the diabetic disease…
Pancreatic islets are composed by different cell types, including insulin secreting ² cells, whose activity are modulated by circulating nutrients. Mechanisms of nutrient stimulated insulin secretion are still unknown. Recently, it was shown that the absence of clock genes Bmal1 and Clock in pancreatic islets reduces insulin secretion and causes hyperglycemia, indicating a participation o…
(Only some records are available in English at this moment)
| 21 / 11 | Completed research grants |
| 31 / 7 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 56 / 22 | All research grants and scholarships |
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