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Possible protective effects of EPA and DHA against apoptosis induced by palmitate in pancreatic islets in culture

Grant number: 12/16374-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2012
Effective date (End): February 28, 2017
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Angelo Rafael Carpinelli
Grantee:Camila Ferraz Lucena Monaco
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:09/51893-0 - The role of NAD(P)H oxidase in the molecular mechanisms of pancreatic beta cell physiology, AP.TEM


Insulin secretion is stimulated by circulating glucose, but the fatty acid (FA) may influence the secretory process induced by glucose (GSIS). The É-3 polyunsaturated FA interfere with several physiological processes, such as regulation of the concentration of plasma lipids, immune function and cardiovascular, peripheral insulin action, neuronal development and visual function. É-3 FA have effects on the composition and function of the plasma membrane, signaling and regulation of gene expression in different tissues, promoting potent anti-inflammatory action.Unpublished data from my master, showed that the islets of animals supplemented with fish oil had significantly lower content of O2 in the presence of * 5.6 and 16.7mM glucose, as compared to control. Moreover, supplementation reduced the expression of the subunits of NAD (P) H oxidase and increased expression of the enzyme superoxide dismutase (SOD 1 and 2). Although still unknown, whatever the mechanism that decreased the content of reactive oxygen species (ROS) of the pancreatic islets of animals subjected to daily intake of fish oil, this data is relevant, because it represents better regulation of the redox state during insulin secretory.The increase in antioxidant defense may have a protective effect against dysfunction and ² cell apoptosis induced by AGEs, since they increase the generation of ROS, possibly via NADPH oxidase. Thus, it becomes important to study the mechanisms involved in the process

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LUCENA, CAMILA F.; ROMA, LETICIA P.; GRACIANO, MARIA FERNANDA R.; VERAS, KATHERINE; SIMOES, DANIEL; CURI, RUI; CARPINELLI, ANGELO R. Omega-3 Supplementation Improves Pancreatic Islet Redox Status In Vivo and In Vitro Studies. PANCREAS, v. 44, n. 2, p. 287-295, MAR 2015. Web of Science Citations: 6.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MONACO, Camila Ferraz Lucena. EPA and DHA treatment protects pancreatic beta cells against palmitic acid-induced dysfunction.. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas São Paulo.

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