Grant number: | 12/16374-4 |
Support Opportunities: | Scholarships in Brazil - Doctorate |
Start date: | November 01, 2012 |
End date: | February 28, 2017 |
Field of knowledge: | Biological Sciences - Physiology - General Physiology |
Principal Investigator: | Angelo Rafael Carpinelli |
Grantee: | Camila Ferraz Lucena Monaco |
Host Institution: | Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Associated research grant: | 09/51893-0 - The role of NAD(P)H oxidase in the molecular mechanisms of pancreatic beta cell physiology, AP.TEM |
Abstract Insulin secretion is stimulated by circulating glucose, but the fatty acid (FA) may influence the secretory process induced by glucose (GSIS). The É-3 polyunsaturated FA interfere with several physiological processes, such as regulation of the concentration of plasma lipids, immune function and cardiovascular, peripheral insulin action, neuronal development and visual function. É-3 FA have effects on the composition and function of the plasma membrane, signaling and regulation of gene expression in different tissues, promoting potent anti-inflammatory action.Unpublished data from my master, showed that the islets of animals supplemented with fish oil had significantly lower content of O2 in the presence of * 5.6 and 16.7mM glucose, as compared to control. Moreover, supplementation reduced the expression of the subunits of NAD (P) H oxidase and increased expression of the enzyme superoxide dismutase (SOD 1 and 2). Although still unknown, whatever the mechanism that decreased the content of reactive oxygen species (ROS) of the pancreatic islets of animals subjected to daily intake of fish oil, this data is relevant, because it represents better regulation of the redox state during insulin secretory.The increase in antioxidant defense may have a protective effect against dysfunction and ² cell apoptosis induced by AGEs, since they increase the generation of ROS, possibly via NADPH oxidase. Thus, it becomes important to study the mechanisms involved in the process | |
News published in Agência FAPESP Newsletter about the scholarship: | |
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