Denise Vilarinho Tambourgi in research grants and scholarships supported by FAPESP.
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CENTD's focus is to combine the expertise of researchers at the Butantan Institute (biochemistry, OMICS, molecular and cellular biology, pharmacology, genetics, bioinformatics, immunology, and in vitro and in vivo assays) with GSK's experience in the search and validation of new targets related to immune-inflammatory diseases, to enable the design and development of new therapeutic agents…
Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan Institute historically built its strong international reputation. Indeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
Successful drug development requires a disease target that plays a vital role in the causation and/or progression of the disease phenotype and that can be modulated with a drug molecule. In other words, therapeutically relevant targets are both “disease-modifying” and “druggable”. It has been estimated that around 10% of the entire human genome is involved in disease onset or progression,…
(Only some records are available in English at this moment)
Loxoscelism is the clinical condition caused by the bite of spiders of the genus Loxosceles, whose most common symptom is dermonecrosis. Enevnoming by brown spiders can cause more severe symptoms such as intravascular hemolysis, intravascular coagulation and impaired renal function, the main cause of death. Sphingomyelinase D (SMase D) is the key component, present in the venom and respon…
The complement system, one of the first lines of defense of the innate immunity, is a major mechanism by which the body recognizes foreign substances and pathogens. This system consists of over 40 proteins, among them regulators and membrane-bound receptors and plasma proteins that interact with multiple cells and mediators of the immune system. These interactions vary according to the pa…
Osteoarthritis is a chronic degenerative disease of the joint, characterized by progressive degradation of cartilage and bone damage, and the mechanisms that drive it are widely investigated. The events can produce irreversible calcification of the matrix cartilage and the induction of the expression of pro-inflammatory cytokines, matrix metalloproteinases (MMPs) and apoptotic factors by …
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 14 / 5 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 34 / 14 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 54 / 24 | All research grants and scholarships |
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