CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas (FCM) (Institutional affiliation from the last research proposal) Birthplace: Nigéria
BSc in Biochemistry and Zoology from Leeds Metropolitan University (1985) and PhD in Physiology from the University of London (1988). Fields of interest: Biochemical Pharmacology and Toxinology (study of animal venoms and toxins). (Source: Lattes Curriculum)
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As desoxirribonucleases (DNases) são endonucleases presentes em peçonhas de serpentes que hidrolisam ácido desoxirribonucléico (DNA). Sua ação no envenenamento ocorre em conjunto com outras enzimas que quebram ligações fosfato (ATPases, 5-nucleotidases, fosfodiesterases, ribonucleases). Vários estudos sobre endonucleases em mamíferos sugerem que a DNase II (DNase ácida) seria responsável …
The intravenous administration of venom from various Bothrops snake species results in immediate hypotension that is mediated primarily by the release of bradykinin, the action of which is potentiated by bradykinin-potentiating factors. Although this hypotensive effect has been known for more than 50 years, there has been no detailed analysis of the hemodynamic alterations produced by the…
O envenenamento botrópico produz efeitos tocais (edema, dor, hemorragia, necrose) e sistêmicos (coagulopatia, hemorragia sistêmica e insuficiência renal aguda - IRA). Dos efeitos sistêmicos, a IRA é a principal causa de óbitos nos acidentes botrópicos. Neste estudo, pretendemos investigar algumas das possíveis vias intracelulares envolvidas no dano renal causado pela peçonha de Bothrops a…
(Only some records are available in English at this moment)
Coral snake (Micrurus spp.) venoms are well-known for their neurotoxicity mediated primarily by a-neurotoxins that act postsynaptically and b-neurotoxins (neurotoxic phospholipases - PLA2) that act presynaptically. Among the Micrurus spp. that have been screened for neurotoxicity, the venom of M. lemniscatus lemniscatus is of particular interest because of its strong presynaptic activity…
L-Amino acid oxidases (LAAO) are enzymes with a wide distribution among animal venoms, particularly in snakes. Various studies have shown that LAAOs exert a variety of biological activities such as the inhibition or stimulation of platelet aggregation and the induction of apoptosis and edema, in addition to antimicrobial, antiviral, antiparasite and antitumor activities. Macrophages play …
As serpentes do gênero Lachesis são as maiores representantes da família Viperidae, subfamília Crotalinae, da América Latina. A peçonha destas serpentes possui ação-coagulante, proteolítica, hemorrágica e neurotoxina (ativação do sistema nervoso autônomo). Apesar da composição bioquímica da peçonha de Lachesis ser relativamente bem conhecida, pouco se tem estudado sobre suas ações cardiov…
(Only some records are available in English at this moment)
Coral snake (Micrurus spp.) venoms are known primarily for their neurotoxicity, which is mediated primarily by alpha-neurotoxins with postsynaptic activity and beta-neurotoxins (neurotoxic phospholipases - PLA2) with presynaptic activity. Preliminary studies have shown that venom of the coral snake Micrurus lemniscatus lemniscatus exerts presynaptic activity involving at least two PLA2 ne…