CV Lattes
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Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Exatas e de Tecnologia (CCET) (Institutional affiliation from the last research proposal) Birthplace: Brazil
I completed my Masters degree in organic chemistry (2013) and then my PhD in synthetic organic chemistry (2017) at the University of São Paulo, Brazil. I am currently a Research Associate in the Department of Chemistry, University of Cambridge. (Source: Lattes Curriculum)
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Common chemotherapeutic agents available in traditional anti-cancer treatments require administration at near the maximum tolerated dosage, lacking tumor selectivity and killing of proliferating normal cells. A recent class of therapy with considerable promise in the treatment of various cancers is the selective targeting of cytotoxic drugs to tumours by conjugating the drug to specific a…
This research project aims to study and increase the range of applications of a,b-unsaturated diazoketones. Considered as potential bifunctional intermediates, these compounds can be used in the quick and efficient synthesis of many molecules of interest, as already demonstrated by Burtoloso et al. In this regard, it will be assessed in detail the Wolff rearrangement in the presence of ne…
Common chemotherapeutic agents available in traditional anti-cancer treatments require administration at near the maximum tolerated dosage, lacking tumor selectivity and killing of proliferating normal cells. A recent class of therapy with considerable promise in the treatment of various cancers is the selective targeting of cytotoxic drugs to tumours by conjugating the drug to specific a…
This project aims at applying the knowledge on the chemistry of alpha,beta-unsaturated diazoketones, developed in our group, to enable the site-selective modification of proteins in collaboration with Prof. Gonçalo Bernardes at University Of Cambridge, UK. Chemical protein modification has emerged as an invaluable tool for understanding natural systems, create therapeutic conjugates with …
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