Abstract
The metabolism of cortisol involves a balance between their active (cortisol or F) and inactive (cortisone or E) forms, which are interconverted by the action of the enzyme 11ß -hydroxysteroid dehydrogenase (11ß - HSD). 21 hidroxylase deficiency (21OHD) is an autosomal recessive disorder, resulting from mutations in the CYP21A2 gene, which encodes the enzyme 21 - hydroxylase. 21OHD corres…