CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. Instituto de Ciência e Tecnologia (ICT) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Licenciatura em Ciências Biológicas from Universidade de São Paulo (2006), bachelor's at Ciencias Biologicas from Universidade de São Paulo (2004), master's at Imunologia from Depato. de Imunologia/Instituto de Ciências Biomédicas/USP (2007) and doctorate at Immunology from Universidade de São Paulo (2010). (Source: Lattes Curriculum)
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In Paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America countries, previous studies revealed that host immunity is regulated by several suppressive mechanisms mediated by plasmacytoid dendritic cells, regulatory T cells, myeloid-derived suppressor cells (MDSCs), as well as, by inhibitory molecules such as CTLA-4 and PD-1. Immunotherapy with monoclonal antibod…
Previous studies in paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, revealed that immunity of hosts is tightly regulated by several suppressive mechanisms mediated by tolerogenic plasmacytoid dendritic cells, the enzyme 2,3 indoleamine dioxygenase (IDO1) and regulatory T cells (Treg). IDO1 was also seen to orchestrate local and systemic immunosuppressiv…
Previous studies in paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, revealed that immunity of hosts is tightly regulated by several suppressive mechanisms mediated by tolerogenic plasmacytoid dendritic cells, the enzyme 2,3 indoleamine dioxygenase (IDO1) and regulatory T cells (Treg). IDO1 was also seen to orchestrate local and systemic immunosuppressiv…
In infectious diseases, the enzyme indolemine 2,3 dioxygenase-1 (IDO1) that catalyzes the tryptophan (Trp) degradation along the kynurenines (Kyn) pathway has two main functions, the control of pathogen growth by reducing available Trp and immune regulation mediated by the Kyn-mediated expansion of regulatory T cells via Aryl hydrocarbon receptor (AhR). In pulmonary paracoccidioidomycosis…
Plasmacytoid dendritic cells (pDCs), considered critical for immunity against viruses, were recently associated with defense mechanisms against fungal infections. However, the immunomodulatory function of pDCs in pulmonary paracoccidiodomycosis (PCM), an endemic fungal infection of Latin America, has been poorly defined. Here, we investigated the role of pDCs in the pathogenesis of PCM ca…
(Only some records are available in English at this moment)
In paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, previous studies have revealed that host immunity is strongly regulated by various suppressive mechanisms mediated by plasmacytoid dendritic cells, the enzyme 2,3 indoleamine dioxygenase (IDO-1), regulatory T cells (Treg), well as negative co-stimulatory molecules such as CTLA-4 and PD-1. Monoclonal ant…
Paracoccidioidomycosis (PCM) is a systemic fungal infection caused by the fungus Paracoccidiodes brasiliensis. It is an endemic disease in the Americas, with a higher incidence in Brazil. The lungs are affected in almost all adult patients, in addition to the oral, pharyngeal and laryngeal mucosal tissues. Current treatment is based on the use of the antifungals itraconazole, amphotericin…
In paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, previous studies have revealed that host immunity is strongly regulated by various suppressive mechanisms mediated by plasmacytoid dendritic cells, the enzyme indoleamine 2,3-dioxygenase (IDO1), regulatory T cells, as well as negative co-stimulatory molecules such as CTLA-4 and PD-1. Immunotherapy with …
Granulomas are important immunological structures in host defense against the dimorphic fungal Paracoccidioides brasiliensis, the main causative agent of Paracoccidioidomycosis (PCM), a chronic systemic mycosis endemic in several Latin America countries. The interaction of P. brasiliensis with the host tissue initially triggers a congestive-exsudative inflammatory reaction, with a predomi…
In paracoccidioidomycosis, the most prevailing systemic mycosis in Latin America, previous studies revealed that the host's immunity is strongly dictated by a diversity of suppressing mechanisms mediated by plasmocytoid dendritic cells, by the 2,3 indoleamine dioxygenase enzyme (IDO1) and regulatory T cells. The activity of IDO1 was demonstrated when orchestrating local and systemic immun…
Granulomas are immunological structures important in the host defense against the thermally dimorphic fungus Paracoccidioides brasiliensis, the main agent causative of Paracoccidioidomycosis (PCM), a systemic chronic mycosis endemic several Latin America countries. The interaction of P. brasiliensis with host tissue initially triggers a congestive-exudative inflammatory reaction with a pr…
(Only some records are available in English at this moment)
In preliminary studies Ramirez-Ortiz et al. 2011, demonstrate that plasmacytoid dendritic cells (pDCs) phagocytose Aspergillus fumigatus conidia and spread over the surface of the hyphal morphotype. In response to hyphal stimulation, pDCs directly inhibit fungal growth and release IFN-± and TNF-±. These studies together with this project challenge the prevailing dogma regarding the specia…
| 2 / 2 | Ongoing grants |
| 6 / 4 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 17 / 12 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 29 / 22 | All research grants and scholarships |
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