CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Ciências Farmacêuticas (FCFAR) (Institutional affiliation from the last research proposal) Birthplace: Brazil
She holds a bachelor's degree in Biological Sciences, and a Master's and a PhD degree in Applied Microbiology, from São Paulo State University - Unesp, campus Rio Claro. She spent two years of her doctorate at the Mannheim University of Applied Sciences, Germany where she later worked as a Postdoc fellow for another two years. She is currently professor at the School of Pharmaceutical Sciences, Unesp campus Araraquara. She is the PI of the research group SynBio Araraquara and the primary PI of the Unesp Brazil team at iGEM. Research interests: synthetic biology; regulation of gene expression in microorganisms; heterologous gene expression. (Source: Lattes Curriculum)
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The transition from an economy based on fossil fuels to a bioeconomy is an important step toward reducing global carbon emissions. In addition, safety and health concerns associated with the production and use of synthetic compounds have fueled an increasing demand for environmentally sustainable natural products. An increasing part of the bioeconomy is played by the production of biocomp…
The currently employed tools to redirect metabolic flux through a specific pathway are deletion and/or insertion of regulatory sequences or genes in the bacterial chromosome. These methods permanently modify the pathway perturbing the metabolic balance during the lag growth phase, what generally extends this process and also decreases cell viability. This project proposes the construction…
No último ano, o grupo de pesquisa SynBio desenvolveu duas cepas bacterianas para a produção de indigoidina, a heterotrófica Bacillus subtilis e a quimiotrófica Cupriavidus necator. Em seguida, editamos modelos metabólicos em escala genômica disponíveis para incluir a via biossintética e os precursores da indigoidina. Com base nos alvos identificados pela análise in silico dos fluxos meta…
The Search for biosustainable solutions for industrial production of compunds of interest is one of the most major objectives of biotechnology and synthetic biology. A range of products can be synthesized by biotechnological routes. Nevertheless, we are still far away of the real potential of industrial biotechnology. To achive this goals, to developed microbial strains that are able to o…
Synthetic biology has been one of the main targets of study when it comes to productions with less environmental impact. Recent studies on the biosynthesis of cyclic lipopeptides, molecules with surfactant properties and wide applicability in industries, stand out among these productions. The main challenge is to produce it quickly, sustainably, and at a low cost, which can be solved usin…
(Only some records are available in English at this moment)
Chemical synthesis of products often uses toxic reagents and solvents, and non-renewable raw material, resulting in the generation of environmentally harmful waste. In contrast, biosynthesis stands out for its sustainable production, use of raw materials from renewable sources, mild production conditions, and low waste generation that are generally non-toxic. This approach has gained incr…
Toehold switches are synthetic elements designed to detect the presence of a trigger RNA and control gene expression at the translational level. These switches have found diverse applications, including serving as biosensors, enzyme screening tools, and regulatory elements for metabolic engineering. Only recently were toehold switches capable of performing transcriptional control designed…
The imminence of climate change has put pressure on the transition from a fossil fuel-based economy to a sustainable bioeconomy. The gases produced by industries are important pollutants in the process of atmospheric gas accumulation and global temperature increase. A promising route for reducing the emission of these gases is their use as feedstock for the production of bioproducts using…
(Only some records are available in English at this moment)
Toehold switches are synthetic elements designed to detect the presence of an RNA trigger and regulate gene expression at the translational level. They have versatile applications as biosensors, enzyme screening tools, and regulatory components for metabolic engineering. Recently, transcriptional toehold switches have been developed, but they remain in the early stages of research and exh…
Cupriavidus necator H16 is a promising bacterium for biotechnological applications aimed at CO2 capture, due to its chemoorganotrophic and chemolithotrophic capabilities. However, engineering tools for C. necator remain limited compared to those available for model organisms. Therefore, this project aims to develop an optimized CRISPR-Cas9 system for C. necator to enhance gene-editing eff…
The production of surfactin, a cyclic lipopeptide, by Bacillus subtilis can be increased using the toolbox of synthetic biology and metabolic engineering. In a previous study, many cultivations were conducted in test tubes to analyze the metabolic state of the strain. The conclusions were that the leucine pathway could be a target for editing, as cultures supplemented with leucine showed …
The consequences of climate change are forcing society to make a transition from a fossil-based economy to a sustainable bioeconomy. Gases produced by industrial activity are important pollutants contributing to greenhouse gas accumulation in the atmosphere and causing changes in global temperatures. A promising route for reducing the rate at which these gases accumulate is to use them as…
One of the main goals of a bioprocess is to gather as much information as possible to allow the development and production of the bioproduct with high yields since the viability of using synthetic systems in an industrial setting depends mostly on the costs of the bioprocess and the yield of the systems. However, traditional methods are still costly, and labour-intensive, and the number o…
| 1 / 1 | Ongoing grants |
| 2 / 2 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 17 / 15 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 29 / 27 | All research grants and scholarships |
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