JEAN PIERRE SCHATZMANN PERON COMPLETED THE SPECIALIZATION IN BIOLOGY APPLIED TO HEALTH AT THE STATE UNIVERSITY OF LONDRINA IN 2003. HE FINISHED THE DOCTORATE IN IMMUNOLOGY [SP-CAPITAL] AT THE UNIVERSITY OF SAO PAULO IN MAY 2008. DURING HIS PHD HE VISITED THE LABORATORY OF PROF. HOWARD L. WEINER AT HARVARD MEDICAL SCHOOL, CENTER FOR NEUROLOGIC DISEASES, BOSTON, MA. HIS LAB IS CURRENTLY FOCUSED ON UNDERSTANDING THE INTERACTIONS BETWEEN THE CENTRAL NERVOUS SYSTEM AND THE IMMUNE SYSTEM. ALSO STUDIES THE CELLULAR AND MOLECULAR MECHANISMS INVOLVED IN THE PATHOGENESIS OF MICROCEPHALY CAUSED BY ZIKA VIRUSES IN EXPERIMENTAL MODELS. HE IS CURRENTLY ASSOCIATE PROFESSOR OF THE DEPARTMENT OF IMMUNOLOGY - USP SÃO PAULO AND SINCE JULY 2019 HE IS A G4 ASSOCIATED RESEARCHER OF THE PASTEUR SCIENTIFIC PLATFORM - USP. HAS THEMATIC PROJECT - FAPESP. HE PUBLISHED 61 ARTICLES IN SPECIALIZED JOURNALS WITH MORE THAN 2600 CITATIONS (FATOR H=18). (Source: Lattes Curriculum)
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The world is going through a dramatic moment. The SARS-CoV-2 pandemic has already affected more than 2 million people worldwide, causing about 160,000 deaths so far. COVID-19 is characterized by the onset of fever and cough, which progresses to pneumonia. 1. Studies show that most people experience cold symptoms, which subside after 10-14 days. However, in some patients, the disease may p…
Diseases of the central nervous system, either autoimmune, degenerative or infectious, are highly complex and debilitating. On one side, the extension of the life expectancy, uncontrolled diets and sedentarism have greatly contributed to the increased prevalence of these diseases on the population, as Alzheimer's, Multiple Sclerosis and Parkinson's Disease. On the other side, the spread o…
The Zika virus (ZIKV) emerges as a global health problem and demands efforts of the scientific community to understand the underlying mechanisms involved in the host cell infection. The ZIKV is part of the flavivirus genus, such as Dengue virus, whose cellular invasion mechanism has been elucidated in the literature. It is clear the involvement of Axl receptor Tyro3 and Mer (Family TAM) a…
It is widely known that cells from the immune system express several different receptors for neurotransmitters. Dopamine, glutamate, serotonin, P substance and VIP (Vasoactive Intestinal Peptide) are a few examples. However little is known concerning its biological functions, as it is seldom the encounter between immune cells and the brain. On the other, it has been demonstrated that in a…
Zika virus (ZIKV) has emerged as a global health problem since it was associated with the increase of microcephaly cases in Brazil between 2015 and 2016, however little is known about the mechanisms used by the virus to trigger this condition. ZIKV is part of the Flavivirus genus and has an interesting central nervous system (CNS) tropism, mainly by neuronal progenitor cells (NPCs) and gl…
The project aims to search for and understand genes that confer resistance or susceptibility to Congenital ZIKV Syndrome, using both samples from women who have had affected babies and experimental models. Sequencing screenings will be carried out, in addition to in vivo validation experiments in a murine model. (AU)
Viral infections have always been the cause of serious human diseases usually increasing rates of morbidity and mortality worldwide. Recently, a flavivirus transmitted by the Aedes aegypti vector, called Zika virus (ZIKV) was introduced in South America, causing a major public health problem. Initially it was not considered a threat to human health, with few cases reported mainly in Afric…
The intestinal mucosa is responsible for harboring a large part of lymphocytes found in all body and together with other cells of the immune system present mainly in the region of the lamina propria play important roles in local tolerance to microorganisms of the microbiota and food antigens. In addition to mucosa, the small and large intestines also present the submucosal layer, the musc…
The Zika virus (ZIKV) emerges as a global health problem and demands efforts of the scientific community to understand the underlying mechanisms involved in the host cell infection. The ZIKV is part of the flavivirus genus, such as Dengue virus, whose cellular invasion mechanism has been elucidated in the literature. It is clear the involvement of Axl receptor Tyro3 and Mer (Family TAM) a…
T CD8 lymphocytes play critical role in controlling infection by some neurotrophic virus by dependent mechanisms of perforin and granzymes, FasL-Fas, or by the production of antiviral cytokines such as IFN-³ or TNF-±. Granzyme B induce apoptosis and DNA fragmentation into target cells. T CD8 cells participate in the eradication of infected cells by West Nile virus, whereas athymic mice ex…
(Only some records are available in English at this moment)
The intestinal mucosa is responsible for harboring a large part of lymphocytes found in all body and together with other cells of the immune system present mainly in the region of the lamina propria play important roles in local tolerance to microorganisms of the microbiota and food antigens. In addition to the mucosa, the small and large intestines also present the submucosal layer, the …
Viral infections have always been the cause of serious human diseases, usually increasing rates of morbidity and mortality worldwide. Recently, the flavivirus Zika virus (ZIKV) was introduced in Brazil causing an alarming increase in the number of babies born with microcephaly. The activation of the antiviral immune response is very important in blocking viral replication but also detrime…
CD8 effector T cells are important in control viruses' infections and cancer growth using cytolytic mechanisms as granzyme and perforin secretion, Fas-FasL interaction and by IFN-³ and TNF-± cytokines. Differently of these cells, CD8 regulatory T (CD8regs) cells have potent suppressive and regulatory functions as compared to CD4regs cells. These activities can occur by Fas-FasL interactio…
Zika virus (ZIKV) emerged as a global health problem and demands effort of the scientific community to understand the underlying mechanisms involved in host-virus interaction. ZIKV is part of the flavivirus genus, wich includs Dengue, West Nile, Yellow Fever and many other viruses. As other pathogens, ZIKV also needs host cell receptors, important for invasion. In this context, it is clea…
| 2 / 2 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 8 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 19 / 17 | All research grants and scholarships |
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