Matheus Henrique dos Santos Dias
CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation for the last research proposal) Birthplace: Brazil
PhD from the department of Biochemistry of the University of São Paulo in Brazil (2012). Graduated in Biomedical Sciences in 2005 at the University Bandeirante of São Paulo. Expertise in Biochemistry and molecular biology acting mainly on the following issues: Cell Cycle and Proliferation; Molecular Basis of Cancer; Signal Transduction; Modeling of Signaling Pathways; Genome Editing/Gene Expression Modulation; Flow Cytometry/FACS; Fluorescence microscopy; Molecular Cloning; Mammalian and Bacterial Cell Culture; Senescence and Cell Death. Since 2013, joined Instituto Butantan in São Paulo as a postdoctoral fellow. (Source: Lattes Curriculum)
- Molecular mechanisms of functional interaction between Ras and cyclin D1 in Ras-driven malignant cells, BP.PD
Abstract
K-Ras, H-Ras e N-Ras are part of a family of small GTPases which work as "molecular switches" converting the activation of membrane receptors into activation of intracellular signaling pathways such as the MAPK pathway. Gain-of-function mutations in Ras proteins are found in about to 20% of all human tumors, frequently leading to bad prognosis. Among other proteins whose activity has be...
- Proteome/phosphoproteome networks investigation of the complementary role of Cyclin D1 for Ras-driven malignant transformation, BE.EP.PD
Abstract
We propose that in Ras-driven malignant cells there is a functional interaction between cyclin D1 and this oncogene; in which the main function of cyclin D1 is to guarantee cell survival overcoming the Ras oncogenic stress. We showed in the presented reports that CRISPR-Cas9-mediated cyclin D1 depletion induces p53-independent senescence in Ras-driven carcinoma cells. Moreover, in MEFs ...
| 1 / 1 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 2 / 2 | All Scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 3 |
| Citations | 16 |
| Cit./Article | 5.3 |
| Data from Web of Science | |
DIAS, MATHEUS H.; FONSECA, CECILIA S.; ZEIDLER, JULIANNA D.; ALBUQUERQUE, LAYRA L.; DA SILVA, MARCELO S.; CARARO-LOPES, EDUARDO; REIS, MARCELO S.; NOEL, VINCENT; DOS SANTOS, EDMILSON O.; PRIOR, IAN A.; et al. Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitors. MOLECULAR ONCOLOGY, v. 13, n. 2, p. 290-306, FEB 2019. Web of Science Citations: 0. (12/20186-9, 13/09040-5, 13/24212-7, 16/17945-6)
DIAS, MATHEUS H.; KITANO, EDUARDO S.; ZELANIS, ANDRE; IWAI, LEO K.. Proteomics and drug discovery in cancer. DRUG DISCOVERY TODAY, v. 21, n. 2, p. 264-277, FEB 2016. Web of Science Citations: 12. (14/06579-3, 13/07467-1, 11/11308-0, 12/20186-9)
ZEIDLER, JULIANNA D.; FERNANDES-SIQUEIRA, LORENA O.; CARVALHO, ANA S.; CARARO-LOPES, EDUARDO; DIAS, MATHEUS H.; KETZER, LUISA A.; GALINA, ANTONIO; DA POIAN, ANDREA T.. Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria. Journal of Biological Chemistry, v. 292, n. 34, p. 14176-14187, AUG 25 2017. Web of Science Citations: 4. (12/20186-9)