- Research Grants
PhD from the department of Biochemistry of the University of São Paulo in Brazil (2012). Graduated in Biomedical Sciences in 2005 at the University Bandeirante of São Paulo. Expertise in Biochemistry and molecular biology acting mainly on the following issues: Cell Cycle and Proliferation; Molecular Basis of Cancer; Signal Transduction; Modeling of Signaling Pathways; Genome Editing/Gene Expression Modulation; Flow Cytometry/FACS; Fluorescence microscopy; Molecular Cloning; Mammalian and Bacterial Cell Culture; Senescence and Cell Death. Since 2013, joined Instituto Butantan in São Paulo as a postdoctoral fellow. (Source: Lattes Curriculum)
K-Ras, H-Ras e N-Ras are part of a family of small GTPases which work as "molecular switches" converting the activation of membrane receptors into activation of intracellular signaling pathways such as the MAPK pathway. Gain-of-function mutations in Ras proteins are found in about to 20% of all human tumors, frequently leading to bad prognosis. Among other proteins whose activity has be...
We propose that in Ras-driven malignant cells there is a functional interaction between cyclin D1 and this oncogene; in which the main function of cyclin D1 is to guarantee cell survival overcoming the Ras oncogenic stress. We showed in the presented reports that CRISPR-Cas9-mediated cyclin D1 depletion induces p53-independent senescence in Ras-driven carcinoma cells. Moreover, in MEFs ...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|