Francisco de Azambuja

• Abstract

  Asymmetric catalysis is a permanent and highly relevant challenge in synthetic organic chemistry. Recently, the Heck arylation with aryldiazonium salts became part of a small group of asymmetric catalytic transformations employing chiral bidentate N,N-ligands. Nevertheless, this innovation is still a privilege for non-activated alkenes, cyclic or acyclic. Thus, it is our goal to develop t…

  Enantioselective Heck-Matsuda Reaction in non-Symmetric Cyclic Olefins: exploiting the catalyst control over the isomerization, BP.PD

• Abstract

  New Pd(II) and Rh(III) catalysed C-H activations methods were developed to the obtaining of potential biologically active molecules, particularly 1,1- e 1,2-diarylethanes. With palladium, the Fujiwaras hydroarylation of alkynes was investigated as a fast, mild and direct method to the synthesis of -aryl--heteroaryl acrylates. Initially, the mechanism of this reaction was studied using nuc…

  C-H activations catalysed by Pd(II) and Rh(III): methodological and mechanistic studies to the synthesis of diarylethane and congeners and evaluations of its biological activity, BP.DR
• Study and synthetic application of Heck-Matsuda arylation with dehydrohidroxy esters and dehydroamino esters, BP.MS

(Only some records are available in English at this moment)

• Abstract

  This proposal aims at putting together the last findings in my PhD work related to the Fujiwara's hydroarylation of alkynes and the later achievements of the research group on the asymmetric Heck-Matsuda reaction. Our goal is the development of new synthetic tools using the metal catalyzed C-H activation as the main strategy to provide enantioenriched compounds in a practical and efficien…

  Development of a new intermolecular asymmetric Fujiwara-Moritani reaction: a new synthetic tool to obtain biologically active moieties, BE.EP.DR