CV Lattes
ResearcherID
ORCID
Google Scholar Citations
Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
DVM - Universidade de Brasília (2006). Master - Allergology and Clinical Immunology - UFMUSP (2009). PhD in Immunology - Universidade de São Paulo (2011). Post doctoral at the Division of Endocrinology, Metabolism and Diabetes, Beth Israel Deaconess Medical Center, Harvard Medical School. Professor in Immunology at the university of Campinas. The areas of research include: immunometabolism, diabetes and obesity. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Los efectos del covid-19 |
| More itemsLess items |
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
The project aims to transform the NB1 animal facility if the Institute of Biology of the UNICAMP into a Biosafety Level 2 (NB2) animal facility, allowing the safe handling of Class 2 Risk pathogens, such as those that cause leishmaniasis, Chagas disease, and viral infections. Currently, the NB1 classification limits the performance of research with these pathogens, requiring relocation to…
Microglia and neuroinflammation in the spinal cord are major contributors to central sensitization and chronic pain development but their phenotype dynamics and molecular contributions during pain are poorly understood. Defining the mechanisms by which microglial lipid metabolism affects immune responses and neuronal sensitization will improve our understanding and help to better identify…
The present project aims to acquire the Agilent Seahorse XF Imaging and QX200 Droplet Digital PCR System equipment to enhance and strengthen the capabilities of the multi-user Facility for metabolism and flow cytometry at the Institute of Biology of Unicamp. Currently, the Facility, in the metabolism area, has two equipment pieces acquired with FAPESP funding for real-time metabolic stud…
(Only some records are available in English at this moment)
The gut microbiota and the innate and adaptive immune systems within the gastrointestinal tract are major contributors to host health, but their functional interactions within sex and across the lifespan remain incompletely defined. Defining the mechanisms by which gut microbial metabolites regulate host gut immune responses will improve our understanding of how to better leverage the gut…
The biochemical of activities occurring in mitochondria are linked to mitochondria morphology. For example, the spatial segregation of biochemical pathways ultimately controls oxidative phosphorylation and energy generation. Systemic and tissue-derived cues shape mitochondria through fission/fusion events, which orchestrates how mitochondria will function. In the immune system, effector c…
The pandemic of the new severe acute respiratory syndrome virus (SARS-CoV-2) has already been confirmed in more than 700,000 people on all continents and has been responsible for more than 20,000 deaths worldwide (World Health Organization - official data of March 27, 2020). The only way to treat severe cases is through respiratory support with still unsatisfactory results. To date, there…
(Only some records are available in English at this moment)
Macrophages are highly plastic innate immune cells that originate from distinct waves of hematopoiesis during embryonic development and from bone marrow-derived monocytes in adulthood. Their differentiation and function are influenced by environmental cues, including transcription factors such as Hypoxia-Inducible Factor 1-alpha (HIF-1¿). HIF-1¿ plays a crucial role in metabolic reprogram…
In obesity, expanded adipose tissue secretes TNF-alfa, IL-6, and IL-1beta, activating immune cells and promoting chronic low-grade inflammation. These cytokines interfere with insulin signaling by repressing the phosphorylation of the insulin receptor and IRS proteins, compromising the PI3K/AKT pathway and reducing glucose uptake, contributing to insulin resistance in type 2 diabetes. In …
Mitochondrial dynamics are essential for cellular adaptation, yet their regulation in immune cells and impact on immune responses remain poorly understood. This study investigates the role of hypoxia-inducible factor-1a (HIF-1a) in the development of mitochondrial dysfunction during macrophage-mediated inflammation. Preliminary findings indicate that HIF-1a stabilization occurs prior to m…
(Only some records are available in English at this moment)
Adipose tissue can be divided into three major types: white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue (BeAT). BAT and BeAT generate heat by oxidizing fatty acids, while white adipocytes handle fat storage. Adaptative thermogenesis (Adaptative thermogenesis) produces heat through brown and beige adipocytes. During cold exposure BAT increases UCP1 expression…
Pro-inflammatory macrophages, as those activated with LPS and INF-³ (³), are characterized by NF-ºB activation, pro-inflammatory cytokine induction (IL-1, IL-6, IL-12, TNF-±), and nitric oxide (NO) and reactive oxygen species (ROS) production. One source of ROS rapidly activated in phagocytes is NADPH-oxidase, regulated by NF-ºB, which directly controls gp91phox gene expression. M(LPS/³)…
(Only some records are available in English at this moment)
The complex neural and molecular mechanisms regulating hunger, focusing particularly on AgRP neurons and their interactions with hypothalamic circuits and microglia remains to be fully explored. Hunger is a biological signal that arises when energy stores are low, triggering responses from hormones like ghrelin and leptin and promoting feeding behavior to maintain energy homeostasis.AgRP …
Macrophages play a central role in the pathophysiology of multiple diseases. Their plasticity allows them to adopt inflammatory or resolutive profiles depending on the microenvironment and relies on reprogramming of cellular metabolism. Recently, TCA cycle-derived metabolites, such as succinate, ¿-ketoglutarate, itaconate and fumarate, have emerged as key mediators of macrophages resoluti…
The recognition of bacterial components by macrophages triggers the production of inflammatory mediators, such as hydrogen peroxide (ROS), and cytokines, including TNF-a, IL-6, and IL-1b. This profile can be induced in macrophages activated with LPS plus IFN-a (M(LPS/y)) and depends on glucose metabolism and stabilization of hypoxia inducible factor-1a (HIF-1a). Glucose is necessary for N…
Macrophages are key cells for the maintenance of tissue homeostasis, for example, through phagocytosis of dead cells, which is an immunological "silent" process. By contrast, macrophages activated by pathogens are a primary host defense mechanism and via the production of oxygen and nitrogen radicals necessary to kill pathogens, can also damage tissues. ROS production causes oxidative dam…
(Only some records are available in English at this moment)