CV Lattes
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ORCID
Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
DVM - Universidade de Brasília (2006). Master - Allergology and Clinical Immunology - UFMUSP (2009). PhD in Immunology - Universidade de São Paulo (2011). Post doctoral at the Division of Endocrinology, Metabolism and Diabetes, Beth Israel Deaconess Medical Center, Harvard Medical School. Professor in Immunology at the university of Campinas. The areas of research include: immunometabolism, diabetes and obesity. (Source: Lattes Curriculum)
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The present project aims to acquire the Agilent Seahorse XF Imaging and QX200 Droplet Digital PCR System equipment to enhance and strengthen the capabilities of the multi-user Facility for metabolism and flow cytometry at the Institute of Biology of Unicamp. Currently, the Facility, in the metabolism area, has two equipment pieces acquired with FAPESP funding for real-time metabolic stud…
The gut microbiota and the innate and adaptive immune systems within the gastrointestinal tract are major contributors to host health, but their functional interactions within sex and across the lifespan remain incompletely defined. Defining the mechanisms by which gut microbial metabolites regulate host gut immune responses will improve our understanding of how to better leverage the gut…
The XFp96e analyzer simultaneously measures, in real time, the two main energy pathways of a cell, mitochondrial respiration and glycolysis in non-sensor-labeled cells, in microplate format. Thus, it is possible to isolate cells, such as different subtypes of macrophages, lymphocytes, adipocytes, among other cell types, and culture them in microplates to evaluate their metabolic profile. …
(Only some records are available in English at this moment)
The biochemical of activities occurring in mitochondria are linked to mitochondria morphology. For example, the spatial segregation of biochemical pathways ultimately controls oxidative phosphorylation and energy generation. Systemic and tissue-derived cues shape mitochondria through fission/fusion events, which orchestrates how mitochondria will function. In the immune system, effector c…
The pandemic of the new severe acute respiratory syndrome virus (SARS-CoV-2) has already been confirmed in more than 700,000 people on all continents and has been responsible for more than 20,000 deaths worldwide (World Health Organization - official data of March 27, 2020). The only way to treat severe cases is through respiratory support with still unsatisfactory results. To date, there…
The field of Immunometabolism is the new frontier for Immunology as it integrates the historically distinct disciplines of Metabolism and Immunology. The growing interest in Immunometabolism is fueled by the global obesity epidemic and the strong association between inflammation and metabolic disease. Obesity-induced inflammation is a risk factor for several chronic pathologies and diseas…
Metabolic dysfunction-associated steatohepatitis (MASH) is a most severe form of metabolic dysfunction-associated steatotic liver disease (MASLD). The accumulation and inflammatory polarization of hepatic macrophages is considered a hallmark of progressive disease. Alterations in the metabolic profile of macrophages can profoundly influence their activation state and functionality, influe…
The tumor microenvironment (TME) is mainly composed of tumor cells, and mesenchymal and immune cells. Macrophages that reside within the tumor tissue are defined as tumor-associated macrophages (TAMs). TAMs can influence tumor growth and metastatic processes through interactions with other cell populations in the TME. Hypoxia is a common feature of the TME present in most solid tumors bec…
One of the main contributors to obesity-related insulin resistance is the presence of systemic low-grade chronic inflammation. In addition to serving its primary role in energy storage, adipose tissue functions as an endocrine organ, releasing a diverse array of bioactive molecules in its secretome. This secretome varies based on the type and location of the adipose tissue, exerting disti…
(Only some records are available in English at this moment)
Macrophages are antigen presenting phagocytes that play a central role in the pathophisiology of many diseases. Their plasticity allows them to adopt pro (M1-like) or anti-inflammatory (M2-like) profiles depending on the surrounding cytokine and substrate microenvironment. This versatily relies on their capability to reprogramm cellular metabolism in order to supply its basal energetic de…
Adipose tissue can be divided into three major types: white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue (BeAT). BAT and BeAT generate heat by oxidizing fatty acids, while white adipocytes handle fat storage. Adaptative thermogenesis (Adaptative thermogenesis) produces heat through brown and beige adipocytes. During cold exposure BAT increases UCP1 expression…
(Only some records are available in English at this moment)
Macrophages play a central role in the pathophysiology of multiple diseases. Their plasticity allows them to adopt inflammatory or resolutive profiles depending on the microenvironment and relies on reprogramming of cellular metabolism. Recently, TCA cycle-derived metabolites, such as succinate, ¿-ketoglutarate, itaconate and fumarate, have emerged as key mediators of macrophages resoluti…
Macrophages are key cells for the maintenance of tissue homeostasis, for example, through phagocytosis of dead cells, which is an immunological "silent" process. By contrast, macrophages activated by pathogens are a primary host defense mechanism and via the production of oxygen and nitrogen radicals necessary to kill pathogens, can also damage tissues. ROS production causes oxidative dam…
The recognition of bacterial components by macrophages triggers the production of inflammatory mediators, such as hydrogen peroxide (ROS), and cytokines, including TNF-a, IL-6, and IL-1b. This profile can be induced in macrophages activated with LPS plus IFN-a (M(LPS/y)) and depends on glucose metabolism and stabilization of hypoxia inducible factor-1a (HIF-1a). Glucose is necessary for N…
Activation of the NLRP3 inflammasome follows a "two-step" route: priming and activation. It has been a consensus that the activation step involves a greater efflux of K+, however the mechanism by which the efflux of K+ induces the activation of the inflammasome is not clear yet. Recent studies have shown the essential role of mitochondrial stress in leaking ox-mtDNA into the cytoplasm to …
Macrophages are present in all tissues of vertebrates and play a key role in host defense and tissue homeostasis. During obesity, there is an accumulation of macrophages in adipose tissue (AT). Obesity milieu results in the production of pro-inflammatory cytokines (TNF-± and IL-1²) by AT macrophages (ATMs), leading to AT inflammation and subsequent insulin resistance. Although many propos…
(Only some records are available in English at this moment)
| 5 / 5 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 9 / 9 | Ongoing scholarships in Brazil |
| 27 / 27 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 7 / 7 | Completed scholarships abroad |
| 53 / 53 | All research grants and scholarships |
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